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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
Author / Creator:Cook, David ; Brown, Dearg ; Alexander, Robert ; March, Ruth ; Morgan, Paul ; Satterthwaite, Gemma ; Pangalos, Menelas N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2014-06, Vol.13 (6), p.419-431
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Impact of a five-dimensional framework on R&D productivity at AstraZeneca
Author / Creator:Morgan, Paul ; Brown, Dean G. ; Lennard, Simon ; Anderton, Mark J. ; Barrett, J. Carl ; Eriksson, Ulf ; Fidock, Mark ; Hamrén, Bengt ; Johnson, Anthony ; March, Ruth E. ; Matcham, James ; Mettetal, Jerome ; Nicholls, David J. ; Platz, Stefan ; Rees, Steve ; Snowden, Michael A. ; Pangalos, Menelas N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2018-03, Vol.17 (3), p.167-181
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Implementation of digital health technology in clinical trials: the 6R framework
Author / Creator:Durán, Cristina Ortega ; Bonam, Matthew ; Björk, Elisabeth ; Hughes, Rod ; Ghiorghiu, Serban ; Massacesi, Cristian ; Campbell, Alicyn ; Hutchison, Emmette ; Pangalos, Menelas N. ; Galbraith, Susan
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2023-11, Vol.29 (11), p.2693-2697
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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease
Author / Creator:Jacobsen, J. Steven ; Wu, Chi-Cheng ; Redwine, Jeffrey M. ; Comery, Thomas A. ; Arias, Robert ; Bowlby, Mark ; Martone, Robert ; Morrison, John H. ; Pangalos, Menelas N. ; Reinhart, Peter H. ; Bloom, Floyd E.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (13), p.5161-5166
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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
Author / Creator:Robbins, Jacqueline P. ; Perfect, Leo ; Ribe, Elena M. ; Maresca, Marcello ; Dangla-Valls, Adrià ; Foster, Evangeline M. ; Killick, Richard ; Nowosiad, Paulina ; Reid, Matthew J. ; Polit, Lucia Dutan ; Nevado, Alejo J. ; Ebner, Daniel ; Bohlooly-Y, Mohammad ; Buckley, Noel ; Pangalos, Menelas N. ; Price, Jack ; Lovestone, Simon
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2018-07, Vol.12, p.504
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Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors
Author / Creator:Terunuma, Miho ; Vargas, Karina J. ; Wilkins, Megan E. ; Ramírez, Omar A. ; Jaureguiberry-Bravo, Matías ; Pangalos, Menelas N. ; Smart, Trevor G. ; Moss, Stephen J. ; Couve, Andrés
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (31), p.13918-13923
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
Author / Creator:Douthwaite, Julie A. ; Brown, Christopher A. ; Ferdinand, John R. ; Sharma, Rahul ; Elliott, Jane ; Taylor, Molly A. ; Malintan, Nancy T. ; Duvoisin, Hannah ; Hill, Thomas ; Delpuech, Oona ; Orton, Alexandra L. ; Pitt, Haidee ; Kuenzi, Fred ; Fish, Simon ; Nicholls, David J. ; Cuthbert, Anna ; Richards, Ian ; Ratcliffe, Giles ; Upadhyay, Abhishek ; Marklew, Abigail ; Hewitt, Craig ; Ross-Thriepland, Douglas ; Brankin, Christopher ; Chodorge, Matthieu ; Browne, Gareth ; Mander, Palwinder K. ; DeWildt, Ruud M. ; Weaver, Shane ; Smee, Penny A. ; van Kempen, Joost ; Bartlett, Jon G. ; Allen, Paula M. ; Koppe, Emma L. ; Ashby, Charlotte A. ; Phipps, Julian D. ; Mehta, Nalini ; Brierley, David J. ; Tew, David G. ; Leveridge, Melanie V. ; Baddeley, Stuart M. ; Goodfellow, Ian G. ; Green, Clive ; Abell, Chris ; Neely, Andy ; Waddell, Ian ; Rees, Steve ; Maxwell, Patrick H. ; Pangalos, Menelas N. ; Howes, Rob ; Clark, Roger
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-02, Vol.12 (1), p.3114-11, Article 3114
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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Author / Creator:Jacobsen, J. Steven ; Comery, Thomas A ; Martone, Robert L ; Elokdah, Hassan ; Crandall, David L ; Oganesian, Aram ; Aschmies, Suzan ; Kirksey, Yolanda ; Gonzales, Cathleen ; Xu, Jane ; Zhou, Hua ; Atchison, Kevin ; Wagner, Erik ; Zaleska, Margaret M ; Das, Indranil ; Arias, Robert L ; Bard, Jonathan ; Riddell, David ; Gardell, Stephen J ; Abou-Gharbia, Magid ; Robichaud, Albert ; Magolda, Ronald ; Vlasuk, George P ; Bjornsson, Thorir ; Reinhart, Peter H ; Pangalos, Menelas N
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (25), p.8754-8759
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ArticlesPeer ReviewedFull Text
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Author / Creator:Ruan, Benfang ; Pong, Kevin ; Jow, Flora ; Bowlby, Mark ; Crozier, Robert A ; Liu, Danni ; Liang, Shi ; Chen, Yi ; Mercado, Mary Lynn ; Feng, Xidong ; Bennett, Frann ; von Schack, David ; McDonald, Leonard ; Zaleska, Margaret M ; Wood, Andrew ; Reinhart, Peter H ; Magolda, Ronald L ; Skotnicki, Jerauld ; Pangalos, Menelas N ; Koehn, Frank E ; Carter, Guy T ; Abou-Gharbia, Magid ; Graziani, Edmund I
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.33-38
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Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease
Author / Creator:Jacobsen, J Steven ; Reinhart, Peter ; Pangalos, Menelas N
Publisher:Milwaukee: Springer Nature B.V
Journal title:Neurotherapeutics, 2005-10, Vol.2 (4), p.612
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Missing Steps in the STAIR Case: A Translational Medicine Perspective on the Development of NXY-059 for Treatment of Acute Ischemic Stroke
Author / Creator:Feuerstein, Giora Z ; Zaleska, Margaret M ; Krams, Michael ; Wang, Xinkang ; Day, Mark ; Rutkowski, Julia L ; Finklestein, Seth P ; Pangalos, Menelas N ; Poole, Michael ; Stiles, Gary L ; Ruffolo, Robert R ; Walsh, Frank L
Publisher:London, England: SAGE Publications
Journal title:Journal of cerebral blood flow and metabolism, 2008-01, Vol.28 (1), p.217-219
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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19
Author / Creator:Levin, Myron J. ; Ustianowski, Andrew ; De Wit, Stéphane ; Launay, Odile ; Avila, Miles ; Templeton, Alison ; Yuan, Yuan ; Seegobin, Seth ; Ellery, Adam ; Levinson, Dennis J. ; Ambery, Philip ; Arends, Rosalinda H. ; Beavon, Rohini ; Dey, Kanika ; Garbes, Pedro ; Kelly, Elizabeth J. ; Koh, Gavin C.K.W. ; Near, Karen A. ; Padilla, Kelly W. ; Psachoulia, Konstantina ; Sharbaugh, Audrey ; Streicher, Katie ; Pangalos, Menelas N. ; Esser, Mark T.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2022-06, Vol.386 (23), p.2188-2200
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Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine
Author / Creator:Falsey, Ann R ; Sobieszczyk, Magdalena E ; Hirsch, Ian ; Sproule, Stephanie ; Robb, Merlin L ; Corey, Lawrence ; Neuzil, Kathleen M ; Hahn, William ; Hunt, Julie ; Mulligan, Mark J ; McEvoy, Charlene ; DeJesus, Edwin ; Hassman, Michael ; Little, Susan J ; Pahud, Barbara A ; Durbin, Anna ; Pickrell, Paul ; Daar, Eric S ; Bush, Larry ; Solis, Joel ; Carr, Quito Osuna ; Oyedele, Temitope ; Buchbinder, Susan ; Cowden, Jessica ; Vargas, Sergio L ; Guerreros Benavides, Alfredo ; Call, Robert ; Keefer, Michael C ; Kirkpatrick, Beth D ; Pullman, John ; Tong, Tina ; Brewinski Isaacs, Margaret ; Benkeser, David ; Janes, Holly E ; Nason, Martha C ; Green, Justin A ; Kelly, Elizabeth J ; Maaske, Jill ; Mueller, Nancy ; Shoemaker, Kathryn ; Takas, Therese ; Marshall, Richard P ; Pangalos, Menelas N ; Villafana, Tonya ; Gonzalez-Lopez, Antonio
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2021-12, Vol.385 (25), p.2348-2360
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Rare variant contribution to human disease in 281,104 UK Biobank exomes
Author / Creator:Wang, Quanli ; Dhindsa, Ryan S. ; Carss, Keren ; Harper, Andrew R. ; Nag, Abhishek ; Tachmazidou, Ioanna ; Vitsios, Dimitrios ; Deevi, Sri V. V. ; Mackay, Alex ; Muthas, Daniel ; Hühn, Michael ; Monkley, Susan ; Olsson, Henric ; Wasilewski, Sebastian ; Smith, Katherine R. ; March, Ruth ; Platt, Adam ; Haefliger, Carolina ; Petrovski, Slavé
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-09, Vol.597 (7877), p.527-532
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GABAA receptor membrane trafficking regulates spine maturity
Author / Creator:Jacob, Tija C ; Wan, Qin ; Vithlani, Mansi ; Saliba, Richard S ; Succol, Francesca ; Pangalos, Menelas N ; Moss, Stephen J
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (30), p.12500-12505
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Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses
Author / Creator:Mukherjee, Jayanta ; Cardarelli, Ross A. ; Cantaut-Belarif, Yasmine ; Deeb, Tarek Z. ; Srivastava, Deepak P. ; Tyagarajan, Shiva K. ; Pangalos, Menelas N. ; Triller, Antoine ; Maguire, Jamie ; Brandon, Nicholas J. ; Moss, Stephen J.
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (44), p.11763-11768
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Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory
Author / Creator:Liu, Feng ; Day, Mark ; Muñiz, Luis C ; Bitran, Daniel ; Arias, Robert ; Revilla-Sanchez, Raquel ; Grauer, Steve ; Zhang, Guoming ; Kelley, Cody ; Pulito, Virginia ; Sung, Amy ; Mervis, Ronald F ; Navarra, Rachel ; Hirst, Warren D ; Reinhart, Peter H ; Marquis, Karen L ; Moss, Stephen J ; Pangalos, Menelas N ; Brandon, Nicholas J
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2008-03, Vol.11 (3), p.334-343
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Pioneering government-sponsored drug repositioning collaborations: progress and learning
Author / Creator:Frail, Donald E. ; Brady, Madeleine ; Escott, K. Jane ; Holt, Alison ; Sanganee, Hitesh J. ; Pangalos, Menelas N. ; Watkins, Chris ; Wegner, Craig D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2015-12, Vol.14 (12), p.833-841
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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19
Author / Creator:Levin, Myron J. ; Ustianowski, Andrew ; De Wit, Stéphane ; Launay, Odile ; Avila, Miles ; Templeton, Alison ; Yuan, Yuan ; Seegobin, Seth ; Ellery, Adam ; Levinson, Dennis J. ; Ambery, Philip ; Arends, Rosalinda H. ; Beavon, Rohini ; Dey, Kanika ; Garbes, Pedro ; Kelly, Elizabeth J. ; Koh, Gavin C.K.W. ; Near, Karen A. ; Padilla, Kelly W. ; Psachoulia, Konstantina ; Sharbaugh, Audrey ; Streicher, Katie ; Pangalos, Menelas N. ; Esser, Mark T.
Publisher:Massachusetts Medical Society
Journal title:The New England journal of medicine, 2022-06, Vol.386 (23), p.2188-2200
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Drug development for CNS disorders: strategies for balancing risk and reducing attrition
Author / Creator:Pangalos, Menelas N. ; Schechter, Lee E. ; Hurko, Orest
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2007-07, Vol.6 (7), p.521-532
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Showing 1 to 20 of 47 results

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

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Impact of a five-dimensional framework on R&D productivity at AstraZeneca

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Implementation of digital health technology in clinical trials: the 6R framework

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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

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Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

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Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease

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Missing Steps in the STAIR Case: A Translational Medicine Perspective on the Development of NXY-059 for Treatment of Acute Ischemic Stroke

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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

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Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

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Rare variant contribution to human disease in 281,104 UK Biobank exomes

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GABAA receptor membrane trafficking regulates spine maturity

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Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses

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Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory

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Pioneering government-sponsored drug repositioning collaborations: progress and learning

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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

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Drug development for CNS disorders: strategies for balancing risk and reducing attrition

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