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ArticlesPeer ReviewedFull Text
Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging
Author / Creator:Joseph, Anna-Maria ; Adhihetty, Peter J. ; Wawrzyniak, Nicholas R. ; Wohlgemuth, Stephanie E. ; Picca, Anna ; Kujoth, Gregory C. ; Prolla, Tomas A. ; Leeuwenburgh, Christiaan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-07, Vol.8 (7), p.e69327
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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Author / Creator:Barger, Jamie L. ; Kayo, Tsuyoshi ; Vann, James M. ; Arias, Edward B. ; Wang, Jelai ; Hacker, Timothy A. ; Wang, Ying ; Raederstorff, Daniel ; Morrow, Jason D. ; Leeuwenburgh, Christiaan ; Allison, David B. ; Saupe, Kurt W. ; Cartee, Gregory D. ; Weindruch, Richard ; Prolla, Tomas A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2008-06, Vol.3 (6), p.e2264-e2264
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Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
Author / Creator:Someya, Shinichi ; Xu, Jinze ; Kondo, Kenji ; Ding, Dalian ; Salvi, Richard J ; Yamasoba, Tatsuya ; Rabinovitch, Peter S ; Weindruch, Richard ; Leeuwenburgh, Christiaan ; Tanokura, Masaru ; Prolla, Tomas A
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (46), p.19432-19437
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Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
Author / Creator:Hiona, Asimina ; Sanz, Alberto ; Kujoth, Gregory C. ; Pamplona, Reinald ; Seo, Arnold Y. ; Hofer, Tim ; Someya, Shinichi ; Miyakawa, Takuya ; Nakayama, Chie ; Samhan-Arias, Alejandro K. ; Servais, Stephane ; Barger, Jamie L. ; Portero-Otín, Manuel ; Tanokura, Masaru ; Prolla, Tomas A. ; Leeuwenburgh, Christiaan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-07, Vol.5 (7), p.e11468
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Evolution of the Aging Brain Transcriptome and Synaptic Regulation
Author / Creator:Loerch, Patrick M. ; Lu, Tao ; Dakin, Kelly A. ; Vann, James M. ; Isaacs, Adrian ; Geula, Chengiz ; Wang, Jianbin ; Pan, Ying ; Gabuzda, Dana H. ; Li, Cheng ; Prolla, Tomas A. ; Yankner, Bruce A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2008-10, Vol.3 (10), p.e3329-e3329
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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Author / Creator:Safdar, Adeel ; Bourgeois, Jacqueline M ; Ogborn, Daniel I ; Little, Jonathan P ; Hettinga, Bart P ; Akhtar, Mahmood ; Thompson, James E ; Melov, Simon ; Mocellin, Nicholas J ; Kujoth, Gregory C ; Prolla, Tomas A ; Tarnopolsky, Mark A
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (10), p.4135-4140
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DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Author / Creator:Vermulst, Marc ; Wanagat, Jonathan ; Kujoth, Gregory C ; Bielas, Jason H ; Rabinovitch, Peter S ; Prolla, Tomas A ; Loeb, Lawrence A
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2008-04, Vol.40 (4), p.392-394
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Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice
Author / Creator:Someya, Shinichi ; Kujoth, Gregory C. ; Kim, Mi-Jung ; Hacker, Timothy A. ; Vermulst, Marc ; Weindruch, Richard ; Prolla, Tomas A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-02, Vol.12 (2), p.e0171159
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A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
Author / Creator:Barger, Jamie L. ; Anderson, Rozalyn M. ; Newton, Michael A. ; da Silva, Cristina ; Vann, James A. ; Pugh, Thomas D. ; Someya, Shinichi ; Prolla, Tomas A. ; Weindruch, Richard
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-04, Vol.10 (4), p.e0120738-e0120738
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ArticlesPeer ReviewedFull Text
The Role of Mitochondrial DNA Mutations in Mammalian Aging
Author / Creator:Kujoth, Gregory C ; Bradshaw, Patrick C ; Haroon, Suraiya ; Prolla, Tomas A
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2007-02, Vol.3 (2), p.e24
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Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
Author / Creator:Edwards, Michael G ; Anderson, Rozalyn M ; Yuan, Ming ; Kendziorski, Christina M ; Weindruch, Richard ; Prolla, Tomas A
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2007-03, Vol.8 (1), p.80-80, Article 80
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Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse
Author / Creator:Dillon, Lloye M. ; Hida, Aline ; Garcia, Sofia ; Prolla, Tomas A. ; Moraes, Carlos T.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-09, Vol.7 (9), p.e44335
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ArticlesPeer ReviewedFull Text
A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in C. elegans
Author / Creator:Serna, Eva ; Mastaloudis, Angela ; Martorell, Patricia ; Wood, Steven M. ; Hester, Shelly N. ; Bartlett, Mark ; Prolla, Tomas A. ; Viña, Jose
Publisher:Switzerland: MDPI AG
Journal title:Nutrients, 2020-02, Vol.12 (2), p.486
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ArticlesPeer ReviewedFull Text
Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
Author / Creator:Lee, Cheol-Koo ; Klopp, Roger G. ; Weindruch, Richard ; Prolla, Tomas A.
Publisher:Washington, DC: American Society for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 1999-08, Vol.285 (5432), p.1390-1393
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Transcriptional Profiles Associated with Aging and Middle Age-Onset Caloric Restriction in Mouse Hearts
Author / Creator:Lee, Cheol-Koo ; Allison, David B. ; Brand, Jaap ; Weindruch, Richard ; Prolla, Tomas A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2002-11, Vol.99 (23), p.14988-14993
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Influences of Aging and Caloric Restriction on the Transcriptional Profile of Skeletal Muscle from Rhesus Monkeys
Author / Creator:Kayo, Tsuyoshi ; Allison, David B. ; Weindruch, Richard ; Prolla, Tomas A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (9), p.5093-5098
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Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
Author / Creator:Safdar, Adeel ; Khrapko, Konstantin ; Flynn, James M. ; Saleem, Ayesha ; De Lisio, Michael ; Johnston, Adam P. W. ; Kratysberg, Yevgenya ; Samjoo, Imtiaz A. ; Kitaoka, Yu ; Ogborn, Daniel I. ; Little, Jonathan P. ; Raha, Sandeep ; Parise, Gianni ; Akhtar, Mahmood ; Hettinga, Bart P. ; Rowe, Glenn C. ; Arany, Zoltan ; Prolla, Tomas A. ; Tarnopolsky, Mark A.
Publisher:England: BioMed Central Ltd
Journal title:Skeletal muscle, 2021-03, Vol.11 (1), p.8-1, Article 8
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The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
Author / Creator:Delic, Vedad ; Noble, Kenyaria ; Zivkovic, Sandra ; Phan, Tam-Anh ; Reynes, Christian ; Zhang, Yumeng ; Phillips, Oluwakemi ; Claybaker, Charles ; Ta, Yen ; Dinh, Vinh B. ; Cruz, Josean ; Prolla, Tomas A. ; Bradshaw, Patrick C.
Publisher:England: The Company of Biologists Ltd
Journal title:Biology open, 2018, Vol.7 (11)
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Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions
Author / Creator:Fuke, Satoshi ; Kametani, Mizue ; Yamada, Kazuyuki ; Kasahara, Takaoki ; Kubota‐Sakashita, Mie ; Kujoth, Gregory C. ; Prolla, Tomas A. ; Hitoshi, Seiji ; Kato, Tadafumi
Publisher:United States: BlackWell Publishing Ltd
Journal title:Annals of clinical and translational neurology, 2014-11, Vol.1 (11), p.909-920
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Mitochondrial point mutations do not limit the natural lifespan of mice
Author / Creator:Vermulst, Marc ; Bielas, Jason H ; Kujoth, Gregory C ; Ladiges, Warren C ; Rabinovitch, Peter S ; Prolla, Tomas A ; Loeb, Lawrence A
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2007-04, Vol.39 (4), p.540-543
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Showing 1 to 20 of 51 results

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Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

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Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

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Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

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Evolution of the Aging Brain Transcriptome and Synaptic Regulation

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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

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DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

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Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

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A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3

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The Role of Mitochondrial DNA Mutations in Mammalian Aging

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Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

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Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

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A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in C. elegans

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Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

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Transcriptional Profiles Associated with Aging and Middle Age-Onset Caloric Restriction in Mouse Hearts

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Influences of Aging and Caloric Restriction on the Transcriptional Profile of Skeletal Muscle from Rhesus Monkeys

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Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

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The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts

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Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions

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Mitochondrial point mutations do not limit the natural lifespan of mice

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