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34 results for Quinuclidines+-+pharmacokinetics

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Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies
Author / Creator:Barbier, Ann J., MD, PhD ; Hilhorst, Martijn, PhD ; Vliet, André Van, MD, PhD ; Snyder, Peter, PhD ; Palfreyman, Michael G., PhD ; Gawryl, Maria, PhD ; Dgetluck, Nancy, MS ; Massaro, Monica, MS ; Tiessen, Renger, MD, PhD ; Timmerman, Wia, MS ; Hilt, Dana C., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2015-02, Vol.37 (2), p.311-324
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In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging
Author / Creator:Singh, Dave ; Roche, Nicolas ; Wu, Libo ; Sadafi, Hosein ; De Backer, Jan ; Monshi Tousi, Navid ; Marshall, Jonathan
Publisher:New Zealand: Dove Medical Press Ltd
Journal title:International journal of chronic obstructive pulmonary disease, 2025-01, Vol.20, p.2103-2116
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Population Pharmacokinetic Analysis of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease
Author / Creator:Mehta, Rashmi ; Farrell, Colm ; Hayes, Siobhán ; Birk, Ruby ; Okour, Malek ; Lipson, David A.
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2020-01, Vol.59 (1), p.67-79
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Inhaled Umeclidinium in COPD Patients: A Review and Meta-Analysis
Author / Creator:Pleasants, Roy A. ; Wang, Tiansheng ; Gao, Jinming ; Tang, Huilin ; Donohue, James F.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2016-03, Vol.76 (3), p.343-361
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Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study
Author / Creator:Fu, Chengxiao ; Zhang, Xingfei ; Pei, Qi ; Guo, Chengxian ; Yang, Xiaoyan ; Yang, Shuang ; Huang, Jie ; Yang, Guoping
Publisher:Germany: Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG
Journal title:International journal of clinical pharmacology and therapeutics, 2020-03, Vol.58 (3), p.155-165
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Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study
Author / Creator:Tsuji, D ; Yokoi, M ; Suzuki, K ; Daimon, T ; Nakao, M ; Ayuhara, H ; Kogure, Y ; Shibata, K ; Hayashi, T ; Hirai, K ; Inoue, K ; Hama, T ; Takeda, K ; Nishio, M ; Itoh, K
Publisher:London: Nature Publishing Group UK
Journal title:The pharmacogenomics journal, 2017-10, Vol.17 (5), p.435-440
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Population Pharmacokinetics of Inhaled Umeclidinium and Vilanterol in Patients with Chronic Obstructive Pulmonary Disease
Author / Creator:Goyal, Navin ; Beerahee, Misba ; Kalberg, Chris ; Church, Alison ; Kilbride, Sally ; Mehta, Rashmi
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2014-07, Vol.53 (7), p.637-648
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Pharmacokinetics and Tolerability of Inhaled Umeclidinium and Vilanterol Alone and in Combination in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Trial
Author / Creator:Hu, Chaoying ; Jia, Jingying ; Dong, Kelly ; Luo, Linda ; Wu, Kai ; Mehta, Rashmi ; Peng, Jack ; Ren, Yan ; Gross, Annette ; Yu, Hui
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0121264
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Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Umeclidinium and Vilanterol Alone and in Combination: A Randomized Crossover Trial
Author / Creator:Kelleher, Dennis L. ; Mehta, Rashmi S. ; Jean-Francois, Bernadette M. ; Preece, Andrew F. ; Blowers, James ; Crater, Glenn D. ; Thomas, Paul
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-12, Vol.7 (12), p.e50716
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Palonosetron: In the Prevention of Nausea and Vomiting
Author / Creator:Yang, Lily P. H. ; Scott, Lesley J.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2009-11, Vol.69 (16), p.2257-2278
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Umeclidinium/Vilanterol: First Global Approval
Author / Creator:Scott, Lesley J. ; Hair, Philip
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2014-03, Vol.74 (3), p.389-395
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Effect of netupitant, a highly selective NK1 receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered wi...
Author / Creator:Calcagnile, Selma ; Lanzarotti, Corinna ; Rossi, Giorgia ; Henriksson, Anders ; Kammerer, Klaus Peter ; Timmer, Wolfgang
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Supportive care in cancer, 2013-10, Vol.21 (10), p.2879-2887
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Effects of Moderate Hepatic Impairment on the Pharmacokinetic Properties and Tolerability of Umeclidinium and Vilanterol in Inhalational Umeclidinium Monotherapy and Umeclidinium/Vilanterol Combinatio...
Author / Creator:Mehta, Rashmi, PhD ; Hardes, Kelly, BSc ; Kelleher, Dennis, PhD ; Preece, Andrew, BSc ; Tombs, Lee, MSc ; Brealey, Noushin, MRCGP
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2014-07, Vol.36 (7), p.1016-1027.e2
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Randomized Pharmacokinetic Study Comparing Subcutaneous and Intravenous Palonosetron in Cancer Patients Treated with Platinum Based Chemotherapy
Author / Creator:Sadaba, Belen ; del Barrio, Anabel ; Campanero, Miguel Angel ; Azanza, Jose Ramon ; Gomez-Guiu, Almudena ; Lopez-Picazo, Jose Maria ; Algarra, Salvador Martin ; Grimá, Francisco Guillén ; Prieto, Maria Blanco ; Perez-Gracia, Jose Luis ; Gurpide, Alfonso
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-02, Vol.9 (2), p.e89747
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Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD
Author / Creator:Albertson, Timothy E ; Bowman, Willis S. ; Harper, Richart W. ; Godbout, Regina M. ; Murin, Susan
Publisher:New Zealand: Dove Medical Press Limited
Journal title:International journal of chronic obstructive pulmonary disease, 2019-01, Vol.14, p.1251-1265
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Clinical Pharmacokinetics and Pharmacodynamics of Solifenacin
Author / Creator:Doroshyenko, Oxana ; Fuhr, Uwe
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2009-05, Vol.48 (5), p.281-302
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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Inhaled Doses of Umeclidinium in Healthy Subjects: Two Randomized Studies
Author / Creator:Cahn, Anthony ; Tal-Singer, Ruth ; Pouliquen, Isabelle J. ; Mehta, Rashmi ; Preece, Andrew ; Hardes, Kelly ; Crater, Glenn ; Deans, Amanda
Publisher:Cham: Springer International Publishing AG
Journal title:Clinical drug investigation, 2013-07, Vol.33 (7), p.477-488
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Safety and pharmacokinetic evaluation of repeated intravenous administration of palonosetron 0.75 mg in patients receiving highly or moderately emetogenic chemotherapy
Author / Creator:Ikari, Yosuke ; Ogata, Kentaro ; Nakashima, Yuta ; Sato, Eiichi ; Masaki, Michio ; Katsuya, Hiroo ; Goto, Toshitaka ; Tanaka, Toshihiro ; Ishitsuka, Kenji ; Takamatsu, Yasushi ; Hara, Shuuji ; Tamura, Kazuo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Supportive care in cancer, 2014-07, Vol.22 (7), p.1959-1964
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Review of oral fixed-dose combination netupitant and palonosetron (NEPA) for the treatment of chemotherapy-induced nausea and vomiting
Author / Creator:Lorusso, Vito ; Karthaus, Meinolf ; Aapro, Matti
Publisher:England: Future Medicine Ltd
Journal title:Future oncology (London, England), 2015-02, Vol.11 (4), p.565-577
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Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of Inhaled Once-Daily Umeclidinium in Healthy Adults Deficient in CYP2D6 Activity: A Double-Blind, Randomized Clinical Trial
Author / Creator:Cahn, Anthony ; Mehta, Rashmi ; Preece, Andrew ; Blowers, James ; Donald, Alison
Publisher:Cham: Springer International Publishing
Journal title:Clinical drug investigation, 2013-09, Vol.33 (9), p.653-664
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Showing 1 to 20 of 34 results

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Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

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In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging

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Population Pharmacokinetic Analysis of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease

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Inhaled Umeclidinium in COPD Patients: A Review and Meta-Analysis

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Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study

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Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study

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Population Pharmacokinetics of Inhaled Umeclidinium and Vilanterol in Patients with Chronic Obstructive Pulmonary Disease

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Pharmacokinetics and Tolerability of Inhaled Umeclidinium and Vilanterol Alone and in Combination in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Trial

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Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Umeclidinium and Vilanterol Alone and in Combination: A Randomized Crossover Trial

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Palonosetron: In the Prevention of Nausea and Vomiting

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Umeclidinium/Vilanterol: First Global Approval

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Effect of netupitant, a highly selective NK1 receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered wi...

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Effects of Moderate Hepatic Impairment on the Pharmacokinetic Properties and Tolerability of Umeclidinium and Vilanterol in Inhalational Umeclidinium Monotherapy and Umeclidinium/Vilanterol Combinatio...

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Randomized Pharmacokinetic Study Comparing Subcutaneous and Intravenous Palonosetron in Cancer Patients Treated with Platinum Based Chemotherapy

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Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD

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Clinical Pharmacokinetics and Pharmacodynamics of Solifenacin

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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Inhaled Doses of Umeclidinium in Healthy Subjects: Two Randomized Studies

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Safety and pharmacokinetic evaluation of repeated intravenous administration of palonosetron 0.75 mg in patients receiving highly or moderately emetogenic chemotherapy

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Review of oral fixed-dose combination netupitant and palonosetron (NEPA) for the treatment of chemotherapy-induced nausea and vomiting

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Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of Inhaled Once-Daily Umeclidinium in Healthy Adults Deficient in CYP2D6 Activity: A Double-Blind, Randomized Clinical Trial

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