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1.	John Thomas Baptist, Junior, undated / Talma
Photograph, black and white
2.	Bishop Barker, undated
Photograph, sepia toned
3.	H. Granville Barker, undated
Post card, black and white
4.	Sir Henry Barkly, K.C.B., undated
Captain General and Governor in Chief of the colony of Victoria
Print, black and white
5.	Sir Henry Barkly, undated
Governor of Victoria
Engraving
6.	Barling, undated / Charlemont, Sydney
Photograph, sepia toned
7.	Barlow, undated
Photograph, sepia toned
8.	R.G. Barlow, undated / Elliott & Fry, London
Photograph, sepia toned
9.	Dr. Barnardo, undated / A.E. Williams
Book cover
10.	Ludwig Barnay, undated
“Of the Meiningen Court company
Engraving
Heavily foxed
11.	J.F. Barnes, undated
[Electorate of?] Gundagai
Clipping
12.	James Barnet, F.R.I.B.A.,  1865-1890
Colonial Architect, 1 January 1865 to 30 June 1890
Copy of a photograph
13.	George Barney, born 19 May 1793, died 16 April 1862
Lieutenant Colonel, Royal Engineers
Copy of a photograph
14.	Jaques Barrelier, 1714
Also spelt Jacques Barrelier
Engraving
15.	Jaques Barrelier, 1606-1673
Also spelt Jacques Barrelier
Dominican monk, born in Paris in 1606 and died 1673, author of a “Collection of plants from France, Spain and Italy”
Lithograph
16.	Ada Louise Barrett, undated
Clipping 
17.	Wilson Barrett, undated
“Mr. Wilson Barrett as “Friar John” in Juana”
Engraving
18.	Wilson Barrett, undated
As Rev. Frank Thornhill in “The golden ladder”
Photograph, carte de visite, sepia toned
19.	H.G. Barrie, 1945-1946
Department of Lands, December 1945 – July 1946
Photograph, black and white
Negative at FM2 / 493
20 - 21	George Barrington, 1810 & 1790
Listed left to right
2 engravings
20.	George Barrington, 1 February 1810 / Nuttall, Fisher & Dixon, Liverpool
Engraving
21.	George Barrington, 21 June 1790 / T. Darby, Borough
“Barrington, tried in a cause of outlawry …, taken by stealth in court”
Engraving
22.	George Barrington, undated
Print, sepia toned
23.	G.H. Barrow, December 1890 / Falk, Sydney
Australian Museum staff
Photograph, sepia toned
24.	Alfred Barry, Bishop of Sydney, undated / J. Hubert Newman, Sydney, photograph no. 1
Photograph, sepia toned
25.	Alfred Barry, Bishop of Sydney, undated / J. Hubert Newman, Sydney, photograph no. 2
Photograph, sepia toned
26.	Helen Barry, undated / Lock & Whitfield
As Mabel Huntingford in “The World”
Photograph, sepia toned
27.	Dr. Keith Barry, 1927
Photograph, sepia toned
28.       	Sir Redmond Barry, undated / Johnstone O’Shannessy & Co., Melbourne
3 photographs, sepia toned. 4th photograph is a duplicate of the third
29.	Sir Redmond Barry, undated / Johnstone O’Shannessy & Co., Melbourne
Photograph, sepia toned
30.	Sir Redmond Barry, undated / T.F. Chuck, Melbourne
Photograph, carte de visite, sepia toned
31.	Sir Redmond Barry, undated / N.J. Caire
Photograph, sepia toned
32.	Sir Redmond Barry, undated
Pen and ink drawing
33.	Bartini, comedian, undated
Photograph, carte de visite, coloured
34.	Edmund Barton, 1898
[Electorate of] The Hastings and The Macleay. New South Wales Legislative  Assembly Clipping
35.	Edmund Barton, undated / Nelson Illingworth
Bust (sculpture) of Mr. E. Barton
36.	Edmund Barton, undated
Photograph, black and white
37.	The Hon. Edmund Barton, QC, MLC, NSW, undated
Photograph, black and white
38.	Edmund Barton, undated
Photograph, black and white
Negative available at FM1 / 4387
39.	Sir Edmund Barton, undated
Rt. Hon. Edmund Barton, Premier / R. Jolley, Melbourne
“Souvenir of the inauguration of the Commonwealth, Jan 1st, 1901”
Post card, coloured
40.	Sir Edmund Barton, undated
Photograph, black and white
41.	Colonel W. de Basil, undated
“Founder and Director-General of the Ballet Company now touring Australia”
Clipping
42.	C. Bauhinus Basilius, 1598
Physician, anatomist and botanist, aged 38 in 1598
Engraving
43.	George Bass, 1770-1803 / Keith Macrae Bowden
Book cover, coloured
44.	George Bass, undated
Post card, coloured
45.	George Bass, undated
Sculpture
46.	George Bass, undated
“Portrait of George Bass from a photograph of an old miniature, in the possession of Mr Pownell, solicitor, Russell Square, London. Mr Pownell is the grandson of William Waterhouse (father of Captain Henry Waterhouse) and a nephew of George Bass – (Bass married Captain Henry Waterhouse’s sister).”
47.	George Bass, undated
Photograph, black and white
Negative available at FM1 / 4624
48.	Zillah Bateman, 1928 / Ruskin …?
Photograph, black and white
49.	George Bates, 1800 – 1895 / Scott Barry, Adelaide
Tombstone
Photograph, sepia toned
50.	John Batman, undated / J.H.
Pencil and wash sketch
51.	Admiral Baudin, undated
Engraving?
52.	Nicholas Baudin, undated
Spelt Nicolas?
Commander.
Pen and ink drawing
53.	Nicolas Baudin, 1801 / … Westermayr
Engraving
54.	Nicolas Baudin, undated / dessine d’apres Nature par Joseph Zauffret; et grave par Mecou
Engraving
55.	Nicolas Baudin, “born 1750”
Engraving
56.	Harold Bauer, undated / C.H. Martin, Paris
Photograph, black and white
57.	M. Bauerlin, undated / Herbst, Sydney
Photograph, sepia toned
58.	Gaspar Bauhin, 1560 – 1624
Born 17 January 1560, died 5 December 1624
Engraving
59.	Bavister, Thomas, undated
[Electorate of?] Ashfield
Clipping
60.	Arnold Bax, undated
Print, sepia toned
61.	M.J. Baxter, undated
2 photographs, black and white
Negatives available in Freeman collection, ON6 No. 62739
62.	Arthur Albert Dawson Bayldon, 1905 / Bacon & Co.
Clipping
Frontispiece to “The Western Track”
63.	Barbara Baynton, undated
2 clippings, one on each side
64.	Marshall Bazaine, undated / engraved by Holl from a photograph
Engraving
65.	Dan Beard, undated
““Dan” Beard, idol of the boy scouts”
Clipping
66.	Earl Beauchamp, undated / The Alba Studios, Sydney
Photograph, sepia toned
67.	Beauchamp, William Lygon, 7th Earl, 1899-1900
Governor New South Wales 1899-1900
Post card, black and white
68.	Beauchamp, William Lygon, 7th Earl, undated / The Alba Studios
Photograph, sepia toned
69.	De Beaupuis, 1907 / E. de B(eaupuis?) Hornsby, N.S.W.
“Just for a bit of fun I am sending you the photo of the Wife, the nurse and my son”
Photograph, sepia toned
70.	E. de Beaupuis, December 1905
Signed E. de Beaupuis
Photograph, black and white
71.	William Beaver, undated
Lithograph
From Heads of the people, Nov. 1847, p. 48
72.	Baron Beaverbrook, undated
Clipping
73.	John M. Bechstein, 1957
Naturalist
Engraving
74 - 82	Louis Becke
Folder of photographs and clippings
74.	Louis Becke, undated / Elliott & Fry, London
Photograph, sepia toned
75.	Louis Becke, undated / A. Duperly & Sons , Kingston, Ja(maica?)
Louis Becke standing
Photograph, black and white (2 copies)
76.	Louis Becke, undated / A. Duperly & Sons , Kingston, Ja(maica?), photograph no. 2
Louis Becke seated
Photograph, black and white 
77.	Louis Becke, undated
2 photographs on 1 page: one sepia toned and one black and white
78.	Louis Becke, Autumn 1903
Clipping
79.	Louis Becke, undated
Photograph, black and white version of sepia toned photograph in no. 77
80.	Louis Becke, undated / A. Duperly & Sons, Kingston, Ja(maica?)
Photograph, sepia toned
81.	Louis Becke, undated
Top photograph donated by A.B. Bertie ; bottom photograph dated 1870
3 photographs, cartes de visite, sepia toned
82.	Louis Becke, undated / Elliott & Fry
Photograph, black and white
83.	Louis Becke, undated / Lafayette, Dublin, Glasgow & Manchester
Photograph, sepia toned
84.	Mrs Louis Becke, Sabrina, undated / Talma
Copy of photograph, sepia toned
85.	Mrs Louis Becke, (Sabrina), undated / Rudolph W. Vieler, Eastbourne
Photograph, black and white
86.	Mrs Louis Becke, Sabrina, undated / Elliott & Fry
Copy of photograph, sepia toned
87.	Vernon Becke, 1896
“Received at Deal, England, 20.9.96”
Photograph, sepia toned
88.	Vernon Becke, 11 October 1899 / W.D. Solomons, Armidale
47 years of age
Photograph, sepia toned
89.	Becke (?), Vernon and his sons, undated
Fred, Cecil, Dad, Aubrey
Photograph, sepia toned
90.	Paula Becker-Modersohn, 1876-1907
Clipping
91.	Rutland Beckett, ca. 1913
Post card, black and white
92.	J.H.L. Beckman, 18 January 1906
Golden wedding of Mr. and Mrs. J.H.L. Beckman
Clipping
93.	Alfred Percival Bedford, undated
Photograph, black and white.
From original pencil drawing.
94.	Randolph Bedford, 1919
Photograph, sepia toned
95.	Ruth Bedford, 1936
Clipping
From the “B.P. Magazine”, 1 September 1936
96.	Catherine Esther Beecher, undated
Eldest daughter of Lyman Beecher, and a pioneer of the higher education of women
Clipping with illustration of Catherine
97.	Henry Ward Beecher, undated
Clipping with illustration of Henry
98.	Dr. Lyman Beecher, undated
Clipping with illustration of Lyman
99.	Mrs. Bernard Beere, undated / Falk, Sydney
Photograph, sepia toned
100.	Rev. A. Beg, undated
Photograph, coloured

Box 02: Portrait file, Baptist to Beg, ca. 1560 to 1957

PRESENTED BY MRS K. A. DONKIN, JULY 1940
1. Lieut. Thomas Woore, R.N., H.M.S. "Alligator", Capt. G. R. Lambert (transferred from P1/Woore, Lieut. Thomas).


ORIGINALS LENT FOR COPYING BY MR W. D. DONKIN, DOUBLE BAY, JUNE 1951
2. Sarah Busby (nee Kennedy)...arriving in Sydney in February 1824. Buried at Kirkton, Branxton, N.S.W. (transferred from P1/Busby, Sarah).
3. John Busby, who with his wife Sarah and family of 5 sons and 1 daughter arrived in Sydney, Australia, February 1824, appointed Civil Engineer & Mineral Surveyor...Buried at Kirkton, Branxton, N.S.W. (transferred from P1/Busby, John).


PRESENTED BY A. DOUGLAS, SEPT. 1953
Transferred from SPF/Murrurundi Railway Smash, 1908
4-5. Murrurundi Railway Smash, 17.4.08 / Oriel Studio J. Cust.


PRESENTED BY DOWD, JUNE 1956
6. Wagga Wagga Express [letterhead], 1883 (transferred from SPF/Wagga – Shops – Express Office, 1883).


PRESENTED BY J. A. DOWLING, EDGECLIFF, WOOLLAHRA, AUG., 1930.
7. Edgecliff - Places and properties identified (early sixties). Copy photograph with typescript notes attached verso identifying places and properties (transferred from SPF/Sydney - Suburbs - Edgecliff, c. 1860-65).


PRESENTED BY J. W. DOWLING, JUNE 1924
8. Scene in Port Jackson : Dawes' Battery, the Mail Steamers' anchorage off Moore's Wharf, entrance to Darling Harbor &c. (from a photograph by Freeman Brothers) [copy photograph of engraving] (transferred from SHIPS FILE/Ellora, S.S., 1865).
9. S.S. Sorata ashore in Cape Jervis S.A., 1879 (with additional notes verso of photograph). Transferred from SHIPS FILE/ Sorata.
10. Sydney from about wharf King st looking SW, about 1850 (transferred from SPF/Sydney – Parks – Hyde Park, n.d.).
11. Dry Dock Balmain Sydney / S.T.G. 56[?] Allan & Wigley Lith. Sydney [copy photograph of lithograph] (transferred from SPF/Sydney – Docks – Dry Dock, Balmain).


PRESENTED BY DR DOYLE, 1929
12. Francis Abigail. Late M.P. West[?] Sydney, now a confinee in H.M. Gaol, 1893 (transferred from P1/Abigail, Francis).
13. Edmund Barton (negative available at FM1/4806, transferred from P1/Barton, Edmund).
14. Russell Barton, late M.P. Labor (transferred from P1/Barton, Russell).
15. E. N. C. Braddon (transferred from P1/Braddon, Sir Edward Nicholas Coventry).
16. M. N. G. Bull, M.P. (transferred from P1/Bull, M. N. G.).
17. Sydney Burdekin, M.P. Hawkesbury (transferred from P1/Burdekin, Sydney).
18. The late Geo. Cass, M.P., The Bogan (transferred from P1/Cass, George Edwin).
19. Henry Clarke, M.P. [?] (transferred from P1/Clarke, Henry).
20. Mr Dalton Orange NSW, John E. Redmond M.P. for [?] (negative available at FM1/5047, transferred from P1/Dalton, Thomas?).
21. The Hon. G. Day, M.L.C. formerly M.P. the Hume (transferred from P1/Day, G.).
22. Alfred Deakin (transferred from P1/Deakin, Alfred).
23. The Hon. Douglass, High Commissioner / The "Vanderweyde" Light, 182 Regent St. W. (transferred from P1/Douglas, John, Hon.).
24. Sir Robert Duff K.C.M.G  (transferred from P1/Duff, Sir Robert).
25. The late William Forster, m.P. Gundagai  (transferred from P1/Forster, William).
26. The late B. Freehill  (transferred from P1/Freehill, B.).
27. Jacob Garrard, M.P. Central Cumberland - late of Balmain  (transferred from P1/Garrard, Jacob).
28. Fred Green...in the bush on Dandenong Ranges Victoria...in 1890  (transferred from P1/Green, Fred).
29. Mark John Hammond, gold-miner and politician, ca. 1905 / portrait by unknown photographer (located at Mitchell Library call no. P1/2257).
30. Major Holbonar, M.P. Argyle  (transferred from P1/Holbonar, Major).
31. James Inglis, M.P., New England  (transferred from P1/Inglis, James).
32. The Right Honorable The Marquis Ito, ex-Prime minister of Japan  (transferred from P1/Ito, Marquis).
33. The late Father Gonzalvo[?] Kavanagh, O.P.  (transferred from P1/Kavanagh, Father).
34. J. E. Kelly, Sec [?] / ...Bigney Photographers  (transferred from P1/Kelly, J. E.).
35. George Loughman, late M.P. Murrimbidgee  (transferred from P1/Longman, George).
36. Hon. W. Lyne, M.P. Hume, Minister for Works  (transferred from P1/Lyne, Hon. W.).
37. A. H. McCullock, formerly M.P. Central Cumberland  (transferred from P1/McCullock, A. H.).
38. M. McDonald / Bardwells Studio, Royal Arcade, Melbourne  (transferred from P1/McDonald, M.).
39. John McElhone, formerly M.P. Upper Hunter  (transferred from P1/McElhone, John).
40. John McLaughlin, late M.P. Upper Hunter  (transferred from P1/McLaughlin, John).
41. W. McMillan  (transferred from P1/McMillan, W.).
42. Ninian Melville, M.P., Chairman of Committees. An undertaker by trade (transferred from P1/Melville, Ninian).
43. N. Melville, Esq., M.P. Northumberland / Rigney (transferred from P1/Melville, Ninian).
44. William O'Brien, Irish M.P., 1886 [copy photograph of engraving?] (transferred from P1/O'Brien, William).
45. Dan O'Connor / ... Boyd (transferred from P1/O'Connor, Dan).
46. Yours J. G. O'Connor (transferred from P1/O'Connor, J. G.).
47. R. E. O'Connor (transferred from P1/O'Connor, Hon. R. E.).
48. Joseph Oliffe, formerly M.P. South Sydney (transferred from P1/Oliffe, Joseph).
49. Henry Parkes (transferred from P1/Parkes, Sir Henry).
50. The late W. R. Piddington, M.P. Hawkesbury (transferred from P1/Piddington, W. R.).
51. I. Purves, late M.P. Melbourne (transferred from P1/Purves, I.).
52. George H. Reid, M.P., East Sydney / Rigney Photographer and Portrait Painter (transferred from P1/Reid, Sir George H.)
53-54. Arthur Renwick, formerly M.P. East Sydney (transferred from P1/Renwick, Arthur).
55. Dr. Arthur Renwick, late M.P., Commissioner Chicago Exhibition, 1892-3 (transferred from P1/Renwick, Arthur, 1892-3).
56. The Hon. Chas. Roberts, M.L.C., formerly M.P. The Manning & Hastings (transferred from P1/Roberts, Hon. Charles).
57. The Hon. John See, M.P. Grafton, Colonial Treasurer (transferred from P1/See, Sir John).
58. William Shakespeare [copy photograph of painting] (transferred from P1/Shakespeare, William).
59. Thos. H. Smith, formerly M.P. Penrith (transferred from P1/Smith, Thomas H.).
60. Catherine Helen Spence, born 1825. The first Australian woman to fight for "women’s suffrage". A South Australian Woman (negative available at FM1/5116, transferred from P1/Spence, Catherine Helen).
61. Senator Sir Josiah H. Symon, K.C., K.C.M.G.  (transferred from P1/Symon, Sir Josiah).
62. The Hon. Trickett, M.L.C., formerly M.P. Paddington  (transferred from P1/Trickett, Hon. William Joseph).
63. Robt. Vaughn, M.P. Grenfell  (transferred from P1/Vaughn, Robert).
64. J. W. Walsh, Irish delegate to Australia, 1881 (transferred from P1/Walsh, J. W.).
65. The Hon. R. H. D. White, MLC [?] / A. Symmons, Hunter Street, Newcastle (transferred from P1/White, Hon. R. H. D.).
66. The late Sir Robert Wisdom, late M.P. Morpeth (transferred from P1/Wisdom, Sir Robert).
67. The Hon. J. D. Young, M.L.C., formerly M.P. West Sydney (transferred from P1/Young, Hon. J. D.).


PRESENTED BY MRS E.[?] DRYSDALE, OCT. 1961
68. Alexander Dumas the elder / J. W. Lindt photographer....7 Collins Street East, Melbourne  (transferred from P1/Dumas, Alexander George).
69. Alexander George Dumas (younger), husband of Emmeline Harper..., May 1880 / Batchelder & Co., 41 Collins St. East, Melbourne (transferred from P1/Dumas, Alexander George, the younger).
70. Emmeline Dumas nee Harper, wife of Alexander George Dumas / Vanderwyde, 292 Bourke St, Melb. (transferred from P1/Dumas, Emmeline).
71. George Arnold Dumas, son of Alexander George Dumas (younger) (transferred from P1/Dumas, George Arnold).


ORIGINAL LENT FOR COPYING BY HIS SON, SEPT. 1955
72. Eccleston Frederic Du Faur (negative available at FM1/5152, transferred from P1/Du Faur, Eccleston Frederic).


PRESENTED BY J. DUDLEY, LITHGOW, N.S.W., JULY 1911 OR 1920?
73. Portrait of Governor Macquarie in the Courthouse at Windsor. Photographed from pastel crayon drawing, taken from the original oil painting in Windsor Court House [copy photograph]. See Pxn 93 and catalogue entries (transferred from P1/Macquarie, Lachlan, Gov.).


ORIGINALS LENT FOR COPYING BY MR G. DUGGAN, UNDERBANK VIA DUNGOG, 1962
Transferred from SPF/Dungog district and SPF/Dungog District, 1898-1900 and 1921 or 1922 . Microfilm available at FM3/518.
74. A group taken at Underbank School on the occasion of the farewell to the teacher Mr Sinclair (notes identifying individuals accompany photograph).
75. Underbank Public School, farewell to the teacher Mr Sinclair (notes identifying individuals accompany photograph).
76. Suspension bridge across the Williams River (Tunnyback crossing) on the road to upper Chichester from Dungog...
77. Photo of eight men, horse and cart (notes identifying individuals accompany photograph).
78. Opening of the road to Eccleston from Salisbury i.e. from the Williams Valley to the Alan River Valley.
79. Former bridge over the combined Williams and Chichester Rivers at Bandon Grove on the road from Bendolba to the Chichester Dam.
80. Group of riders probably in the Underbank - Chichester-Dungog area.
81. Probably a combined Underbank and Chichester cricket team, taken about 1898-1900 (notes identifying individuals accompany photograph).
82. Underbank school group, Salisbury Rd via Dungog, N.S.W., 1921 or 1922 (notes identifying individuals accompany photograph).


PRESENTED BY MISSES D. & R. DUMBRELL, MARCH 1962 
83. T.S.S. Loongana, outward bound (transferred from SHIPS FILE/Loongana, S.S.).

Transferred from SPF/Cataract Gorge, Tas. 
84. The Mill Dam, Cataract Gorge, Launceston, Tasmania.
85. Cataract Gorge, Launceston, Tasmania.
86. Cataract Gorge from King's Bridge, Launceston, Tasmania.

87. Hobart from Bellerive, 803 / W. J. Little Photo (transferred from SPF/Hobart, Tas.).
88. Elizabeth Street, Hobart (transferred from SPF/Hobart - Streets - Elizabeth St, before 1914).
89. Launceston from Trevallyn, Tasmania (transferred from SPF/Launceston, Tas.).
90. Princes Square and Christ Church, Launceston, Tasmania (transferred from SPF/Launceston, Tas. - Churches - Christ Church).
91. The Wharves, Lismore (transferred from SPF/Lismore - Wharves).
92. 1101 Sheep crossing a billabong (transferred from SPF/Sheep).
93. Organ pipes, Mt. Wellington, Hobart 907 / Copyright W. J. Little Photo (transferred from SPF/Wellington, Mount, Tasmania).


PRESENTED BY MISSES DUMBRELL, SEP. 1962
94. Mrs Alexander Ross nee Mary Anderson of Newcastle on Tyne (born Gosforth) sailed to Australia in Exodus, about 1880 / Charlemont & Co. (transferred from P1/Ross, Mary).

Transferred from SPG/Bulli Residents
95. Bulli, about 1918, appears to be at the elbow of Bulli Pass.
96-97. Bulli about 1918.

98. Lodden Falls, near Bulli (transferred from SPF/Loddon Falls, N.S.W.).
99. Rydalmere or some school of Edwin Knight in the eighties (i.e. 1880s) / G. V. St. Clare Photographer (transferred from SPG/Rydalmere).
100. [Photograph of house with two children standing in front] (transferred from SPF/Sydney – Suburbs – Rydalmere – Schools – Rydalmere School House, c. 1890).

BOX 17: Mitchell Library, Small Pictures File, Donor Name collections: Donkin to Dumbrell, between 1850? and 1922?

The heretic : by Morris L. West with Bryan Marshall as Giordano Bruno.

Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric disorders (TAND) including autism spectrum disorder (ASD) and intellectual disability. Hamartin (TSC1) and tuberin (TSC2) proteins form a complex inhibiting mechanistic target of rapamycin complex 1 (mTORC1) signaling. Loss of TSC1 or TSC2 activates mTORC1 that, among several targets, controls protein synthesis by inhibiting translational repressor eIF4E-binding proteins. Using TSC1 patient-derived neural progenitor cells (NPCs), we recently reported early ND phenotypic changes, including increased cell proliferation and altered neurite outgrowth in TSC1-null NPCs, which were unaffected by the mTORC1 inhibitor rapamycin.
Here, we used polysome profiling, which quantifies changes in mRNA abundance and translational efficiencies at a transcriptome-wide level, to compare CRISPR-edited TSC1-null with CRISPR-corrected TSC1-WT NPCs generated from one TSC donor (one clone/genotype). To assess the relevance of identified gene expression alterations, we performed polysome profiling in postmortem brains from ASD donors and age-matched controls. We further compared effects on translation of a subset of transcripts and rescue of early ND phenotypes in NPCs following inhibition of mTORC1 using the allosteric inhibitor rapamycin versus a third-generation bi-steric, mTORC1-selective inhibitor RMC-6272.
Polysome profiling of NPCs revealed numerous TSC1-associated alterations in mRNA translation that were largely recapitulated in human ASD brains. Moreover, although rapamycin treatment partially reversed the TSC1-associated alterations in mRNA translation, most genes related to neural activity/synaptic regulation or ASD were rapamycin-insensitive. In contrast, treatment with RMC-6272 inhibited rapamycin-insensitive translation and reversed TSC1-associated early ND phenotypes including proliferation and neurite outgrowth that were unaffected by rapamycin.
Our work reveals ample mRNA translation alterations in TSC1 patient-derived NPCs that recapitulate mRNA translation in ASD brain samples. Further, suppression of TSC1-associated but rapamycin-insensitive translation and ND phenotypes by RMC-6272 unveils potential implications for more efficient targeting of mTORC1 as a superior treatment strategy for TAND.

Molecular autism, 2023-10, Vol.14 (1), p.39-39, Article 39

Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

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Box 02: Portrait file, Baptist to Beg, ca. 1560 to 1957

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BOX 17: Mitchell Library, Small Pictures File, Donor Name collections: Donkin to Dumbrell, between 1850? and 1922?

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The heretic : by Morris L. West with Bryan Marshall as Giordano Bruno.

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Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

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