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39 results for Retinoblastoma-Like+Protein+p130+-+genetics

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ArticlesPeer ReviewedFull Text
CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer
Author / Creator:Ng, Sheng Rong ; Rideout, William M. ; Akama-Garren, Elliot H. ; Bhutkar, Arjun ; Mercer, Kim L. ; Schenkel, Jason M. ; Bronson, Roderick T. ; Jacks, Tyler
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (1), p.513-521
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Control of glutamine metabolism by the tumor suppressor Rb
Author / Creator:Reynolds, M R ; Lane, A N ; Robertson, B ; Kemp, S ; Liu, Y ; Hill, B G ; Dean, D C ; Clem, B F
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-01, Vol.33 (5), p.556-566
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Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
Author / Creator:Kleinman, Claudia L ; Gerges, Noha ; Papillon-Cavanagh, Simon ; Sin-Chan, Patrick ; Pramatarova, Albena ; Quang, Dong-Anh Khuong ; Adoue, Véronique ; Busche, Stephan ; Caron, Maxime ; Djambazian, Haig ; Bemmo, Amandine ; Fontebasso, Adam M ; Spence, Tara ; Schwartzentruber, Jeremy ; Albrecht, Steffen ; Hauser, Peter ; Garami, Miklos ; Klekner, Almos ; Bognar, Laszlo ; Montes, Jose-Luis ; Staffa, Alfredo ; Montpetit, Alexandre ; Berube, Pierre ; Zakrzewska, Magdalena ; Zakrzewski, Krzysztof ; Liberski, Pawel P ; Dong, Zhifeng ; Siegel, Peter M ; Duchaine, Thomas ; Perotti, Christian ; Fleming, Adam ; Faury, Damien ; Remke, Marc ; Gallo, Marco ; Dirks, Peter ; Taylor, Michael D ; Sladek, Robert ; Pastinen, Tomi ; Chan, Jennifer A ; Huang, Annie ; Majewski, Jacek ; Jabado, Nada
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2014-01, Vol.46 (1), p.39-44
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Hypomorphism of Fto and Rpgrip1l causes obesity in mice
Author / Creator:Stratigopoulos, George ; Burnett, Lisa Cole ; Rausch, Richard ; Gill, Richard ; Penn, David Barth ; Skowronski, Alicja A. ; LeDuc, Charles A. ; Lanzano, Anthony J. ; Zhang, Pumin ; Storm, Daniel R. ; Egli, Dieter ; Leibel, Rudolph L.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-05, Vol.126 (5), p.1897-1910
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The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts
Author / Creator:Vélez-Cruz, Renier ; Johnson, David
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2017-08, Vol.18 (8), p.1776
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miR-17-92 Cluster Accelerates Adipocyte Differentiation by Negatively Regulating Tumor-Suppressor Rb2/p130
Author / Creator:Wang, Qiang ; Li, Yan Chun ; Wang, Jinhua ; Kong, Juan ; Qi, Yuchen ; Quigg, Richard J. ; Li, Xinmin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (8), p.2889-2894
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Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer
Author / Creator:Ullah, Farman ; Khurshid, Nadia ; Fatimi, Qaiser ; Loidl, Peter ; Saeed, Muhammad
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-04, Vol.17 (4), p.e0266196-e0266196
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Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells
Author / Creator:Nakanoh, Shota ; Kadiwala, Juned ; Pinte, Laetitia ; Morell, Carola Maria ; Lenaerts, An-Sofie ; Vallier, Ludovic
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-11, Vol.17 (11), p.e0269122
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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
Author / Creator:Enrico, Taylor P ; Stallaert, Wayne ; Wick, Elizaveta T ; Ngoi, Peter ; Wang, Xianxi ; Rubin, Seth M ; Brown, Nicholas G ; Purvis, Jeremy E ; Emanuele, Michael J
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2021-12, Vol.10
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RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC
Author / Creator:Duan, Lei ; Perez, Ricardo E. ; Calhoun, Sarah ; Maki, Carl G.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-01, Vol.12 (1), p.1049-1049, Article 1049
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ArticlesPeer ReviewedFull Text
MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes
Author / Creator:Liu, F ; Gong, J ; Huang, W ; Wang, Z ; Wang, M ; Yang, J ; Wu, C ; Wu, Z ; Han, B
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-10, Vol.33 (40), p.4813-4822
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RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines
Author / Creator:Pentimalli, Francesca ; Forte, Iris M. ; Esposito, Luca ; Indovina, Paola ; Iannuzzi, Carmelina A. ; Alfano, Luigi ; Costa, Caterina ; Barone, Daniela ; Rocco, Gaetano ; Giordano, Antonio
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2018-07, Vol.37 (27), p.3657-3671
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A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
Author / Creator:Li, Jingling ; Narayanan, Cyndhavi ; Bian, Jing ; Sambo, Danielle ; Brickler, Thomas ; Zhang, Wancong ; Chetty, Sundari
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-12, Vol.13 (12), p.e0208110-e0208110
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Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice
Author / Creator:Zhang, Xiwen ; Chen, Jianxiao ; Xue, Ming ; Tang, Yuying ; Xu, Jingyuan ; Liu, Ling ; Huang, Yingzi ; Yang, Yi ; Qiu, Haibo ; Guo, Fengmei
Publisher:England: BioMed Central Ltd
Journal title:Stem cell research & therapy, 2019-03, Vol.10 (1), p.74-11
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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function
Author / Creator:Samra, Nadra ; Toubiana, Shir ; Yttervik, Hilde ; Tzur-Gilat, Aya ; Morani, Ilham ; Itzkovich, Chen ; Giladi, Liran ; Abu Jabal, Kamal ; Cao, John Z. ; Godley, Lucy A. ; Mory, Adi ; Baris Feldman, Hagit ; Tveten, Kristian ; Selig, Sara ; Weiss, Karin
Publisher:England: Nature Publishing Group
Journal title:Journal of human genetics, 2021-11, Vol.66 (11), p.1101-1112
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Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells
Author / Creator:Alessio, Nicola ; Bohn, Wolfgang ; Rauchberger, Verena ; Rizzolio, Flavio ; Cipollaro, Marilena ; Rosemann, Michael ; Irmler, Martin ; Beckers, Johannes ; Giordano, Antonio ; Galderisi, Umberto
Publisher:Basel: SP Birkhäuser Verlag Basel
Journal title:Cellular and molecular life sciences : CMLS, 2013-05, Vol.70 (9), p.1637-1651
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Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells
Author / Creator:Gandhi, Sivasangkary ; Nor Rashid, Nurshamimi ; Mohamad Razif, Muhammad Fazril ; Othman, Shatrah
Publisher:Dordrecht: Springer Netherlands
Journal title:Molecular biology reports, 2021-06, Vol.48 (6), p.5121-5133
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Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer
Author / Creator:Ullah, Farman ; Khan, Taimoor ; Ali, Nawab ; Malik, Faraz Arshad ; Kayani, Mahmood Akhtar ; Shah, Syed Tahir Abbas ; Saeed, Muhammad
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-08, Vol.10 (8), p.e0134687-e0134687
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High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7’s induction of DNA damage response, an activity mediated by E7’s inactivation of pocket pro...
Author / Creator:Park, J W ; Shin, M-K ; Lambert, P F
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-06, Vol.33 (26), p.3383-3391
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Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis
Author / Creator:Oria, Marc ; Duru, Soner ; Figueira, Rebeca L. ; Scorletti, Federico ; Turner, Lucas E. ; Fernandez-Alonso, Irati ; Fernandez-Martin, Alejandra ; Marotta, Mario ; Sbragia, Lourenco ; Shaaban, Aimen F. ; Peiro, Jose L.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2019-09, Vol.10 (10), p.721-11, Article 721
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Showing 1 to 20 of 39 results

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CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

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Control of glutamine metabolism by the tumor suppressor Rb

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Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR

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Hypomorphism of Fto and Rpgrip1l causes obesity in mice

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The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts

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miR-17-92 Cluster Accelerates Adipocyte Differentiation by Negatively Regulating Tumor-Suppressor Rb2/p130

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Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer

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Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells

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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

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RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC

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MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes

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RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines

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A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family

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Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice

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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function

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Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells

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Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells

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Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer

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High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7’s induction of DNA damage response, an activity mediated by E7’s inactivation of pocket pro...

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Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis

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