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178 results for Reverse+Transcriptase+Inhibitors+-+chemistry

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ArticlesPeer ReviewedFull Text
Less Than 95% Adherence to Nonnucleoside Reverse-Transcriptase Inhibitor Therapy Can Lead to Viral Suppression
Author / Creator:Bangsberg, David R.
Publisher:United States: The University of Chicago Press
Journal title:Clinical infectious diseases, 2006-10, Vol.43 (7), p.939-941
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Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors
Author / Creator:Romeo, Roberto ; Iannazzo, Daniela ; Veltri, Lucia ; Gabriele, Bartolo ; Macchi, Beatrice ; Frezza, Caterina ; Marino-Merlo, Francesca ; Giofrè, Salvatore V.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-05, Vol.24 (9), p.1718
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Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors
Author / Creator:Yang, Yang ; Kang, Dongwei ; Nguyen, Laura A ; Smithline, Zachary B ; Pannecouque, Christophe ; Zhan, Peng ; Liu, Xinyong ; Steitz, Thomas A
Publisher:England: eLife Sciences Publications, Ltd
Journal title:eLife, 2018-07, Vol.7 (2018)
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Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E)
Author / Creator:Parang, Keykavous ; El-Sayed, Naglaa Salem ; Kazeminy, Assad J. ; Tiwari, Rakesh K.
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2020-05, Vol.25 (10), p.2343
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ArticlesPeer ReviewedFull Text
Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
Author / Creator:Mansouri, Mahta ; Rumrill, Shawn ; Dawson, Shane ; Johnson, Adam ; Pinson, Jo-Anne ; Gunzburg, Menachem J. ; Latham, Catherine F. ; Barlow, Nicholas ; Mbogo, George W. ; Ellenberg, Paula ; Headey, Stephen J. ; Sluis-Cremer, Nicolas ; Tyssen, David ; Bauman, Joseph D. ; Ruiz, Francesc X. ; Arnold, Eddy ; Chalmers, David K. ; Tachedjian, Gilda
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.3103
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High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs
Author / Creator:Ha, Betty ; Larsen, Kevin P. ; Zhang, Jingji ; Fu, Ziao ; Montabana, Elizabeth ; Jackson, Lynnette N. ; Chen, Dong-Hua ; Puglisi, Elisabetta Viani
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-05, Vol.12 (1), p.2500-11, Article 2500
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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
Author / Creator:Das, Kalyan ; Bauman, Joseph D ; Clark, Arthur D. Jr ; Frenkel, Yulia V ; Lewi, Paul J ; Shatkin, Aaron J ; Hughes, Stephen H ; Arnold, Eddy
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (5), p.1466-1471
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Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography
Author / Creator:Chan, Albert H. ; Lee, Won-Gil ; Spasov, Krasimir A. ; Cisneros, José A. ; Kudalkar, Shalley N. ; Petrova, Zaritza O. ; Buckingham, Amanda B. ; Anderson, Karen S. ; Jorgensen, William L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (36), p.9725-9730
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Profiling the Interaction between Human Serum Albumin and Clinically Relevant HIV Reverse Transcriptase Inhibitors
Author / Creator:Costa-Tuna, Andreia ; Chaves, Otávio A. ; Almeida, Zaida L. ; Cunha, Rita S. ; Pina, João ; Serpa, Carlos
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2024-03, Vol.16 (4), p.491
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ArticlesPeer ReviewedFull Text
Novel Thiazolidin-4-ones as Potential Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
Author / Creator:Petrou, Anthi ; Eleftheriou, Phaedra ; Geronikaki, Athina ; Akrivou, Melpomeni G. ; Vizirianakis, Ioannis
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-10, Vol.24 (21), p.3821
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ArticlesPeer ReviewedFull Text
Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluat...
Author / Creator:Zhuo, Zongji ; Wang, Zhao ; Jing, Lanlan ; Zhang, Tao ; Ge, Anchao ; Zhou, Zhenzhen ; Liu, Ying ; Li, Xin ; De Clercq, Erik ; Pannecouque, Christophe ; Zhan, Peng ; Liu, Xinyong ; Kang, Dongwei
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-08, Vol.25 (16), p.9028
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ArticlesPeer ReviewedFull Text
Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
Author / Creator:Tu, Nhat Quang ; Richetta, Clémence ; Putzu, Federica ; Delelis, Olivier ; Ahmed, Khursheed ; Masand, Vijay H. ; Schobert, Rainer ; Tramontano, Enzo ; Corona, Angela ; Biersack, Bernhard
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (3), p.495
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ArticlesPeer ReviewedFull Text
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
Author / Creator:Desantis, Jenny ; Massari, Serena ; Corona, Angela ; Astolfi, Andrea ; Sabatini, Stefano ; Manfroni, Giuseppe ; Palazzotti, Deborah ; Cecchetti, Violetta ; Pannecouque, Christophe ; Tramontano, Enzo ; Tabarrini, Oriana
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-03, Vol.25 (5), p.1183
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ArticlesPeer ReviewedFull Text
Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations
Author / Creator:Yasutake, Yoshiaki ; Hattori, Shin-ichiro ; Kumamoto, Hiroki ; Tamura, Noriko ; Maeda, Kenji ; Mitsuya, Hiroaki
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-07, Vol.14 (1), p.15742-13, Article 15742
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Elsulfavirine: First Global Approval
Author / Creator:Al-Salama, Zaina T.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2017-10, Vol.77 (16), p.1811-1816
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ArticlesPeer ReviewedFull Text
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study
Author / Creator:Zhou, Zhenzhen ; Meng, Bairu ; An, Jiaqi ; Zhao, Fabao ; Sun, Yanying ; Zeng, Dan ; Wang, Wenna ; Gao, Shenghua ; Xia, Yu ; Dun, Caiyun ; De Clercq, Erik ; Pannecouque, Christophe ; Zhan, Peng ; Kang, Dongwei ; Liu, Xinyong
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-01, Vol.24 (2), p.1215
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ArticlesPeer ReviewedFull Text
Dextran sodium sulfate inhibits the activities of both polymerase and reverse transcriptase: lithium chloride purification, a rapid and efficient technique to purify RNA
Author / Creator:Viennois, Emilie ; Chen, Fengyuan ; Laroui, Hamed ; Baker, Mark T ; Merlin, Didier
Publisher:England: BioMed Central Ltd
Journal title:BMC research notes, 2013-09, Vol.6 (1), p.360-360, Article 360
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Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening
Author / Creator:Singh, Abhimanyu K. ; Martinez, Sergio E. ; Gu, Weijie ; Nguyen, Hoai ; Schols, Dominique ; Herdewijn, Piet ; De Jonghe, Steven ; Das, Kalyan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-12, Vol.12 (1), p.7127-10, Article 7127
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Azvudine, A Novel Nucleoside Reverse Transcriptase Inhibitor Showed Good Drug Combination Features and Better Inhibition on Drug-Resistant Strains than Lamivudine In Vitro
Author / Creator:Wang, Rui-Rui ; Yang, Qing-Hua ; Luo, Rong-Hua ; Peng, You-Mei ; Dai, Shao-Xing ; Zhang, Xing-Jie ; Chen, Huan ; Cui, Xue-Qing ; Liu, Ya-Juan ; Huang, Jing-Fei ; Chang, Jun-Biao ; Zheng, Yong-Tang
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-08, Vol.9 (8), p.e105617-e105617
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ArticlesPeer ReviewedFull Text
High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance
Author / Creator:Wambaugh, Morgan A. ; Shakya, Viplendra P. S. ; Lewis, Adam J. ; Mulvey, Matthew A. ; Brown, Jessica C. S.
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-06, Vol.15 (6), p.e2001644
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Showing 1 to 20 of 178 results

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Less Than 95% Adherence to Nonnucleoside Reverse-Transcriptase Inhibitor Therapy Can Lead to Viral Suppression

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Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors

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Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

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Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E)

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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

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High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

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Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography

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Profiling the Interaction between Human Serum Albumin and Clinically Relevant HIV Reverse Transcriptase Inhibitors

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Novel Thiazolidin-4-ones as Potential Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

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Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluat...

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Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

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1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

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Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations

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Elsulfavirine: First Global Approval

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Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

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Dextran sodium sulfate inhibits the activities of both polymerase and reverse transcriptase: lithium chloride purification, a rapid and efficient technique to purify RNA

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Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

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Azvudine, A Novel Nucleoside Reverse Transcriptase Inhibitor Showed Good Drug Combination Features and Better Inhibition on Drug-Resistant Strains than Lamivudine In Vitro

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High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

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