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ArticlesPeer ReviewedFull Text
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
Author / Creator:Zhang, Yiying ; Wang, Rao ; Bu, Yueyue ; Corona, Angela ; Dettori, Laura ; Tramontano, Enzo ; Pannecouque, Christophe ; De Clercq, Erik ; Wang, Shuai ; Meng, Ge ; Chen, Fen-Er
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-04, Vol.30 (9), p.1868
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Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
Author / Creator:Tu, Nhat Quang ; Richetta, Clémence ; Putzu, Federica ; Delelis, Olivier ; Ahmed, Khursheed ; Masand, Vijay H. ; Schobert, Rainer ; Tramontano, Enzo ; Corona, Angela ; Biersack, Bernhard
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (3), p.495
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ArticlesPeer ReviewedFull Text
The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes
Author / Creator:Tavis, John E. ; Cheng, Xiaohong ; Hu, Yuan ; Totten, Michael ; Cao, Feng ; Michailidis, Eleftherios ; Aurora, Rajeev ; Meyers, Marvin J. ; Jacobsen, E. Jon ; Parniak, Michael A. ; Sarafianos, Stefan G.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-01, Vol.9 (1), p.e1003125-e1003125
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ArticlesPeer ReviewedFull Text
Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
Author / Creator:Corona, Angela ; Meleddu, Rita ; Esposito, Francesca ; Distinto, Simona ; Bianco, Giulia ; Masaoka, Takashi ; Maccioni, Elias ; Menéndez-Arias, Luis ; Alcaro, Stefano ; Le Grice, Stuart F. J. ; Tramontano, Enzo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-01, Vol.11 (1), p.e0147225
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ArticlesPeer ReviewedFull Text
Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants
Author / Creator:Corona, Angela ; Ballana, Ester ; Distinto, Simona ; Rogolino, Dominga ; Del Vecchio, Claudia ; Carcelli, Mauro ; Badia, Roger ; Riveira-Muñoz, Eva ; Esposito, Francesca ; Parolin, Cristina ; Esté, José A. ; Grandi, Nicole ; Tramontano, Enzo
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2020-07, Vol.12 (7), p.729
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ArticlesPeer ReviewedFull Text
Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities
Author / Creator:Esposito, Francesca ; Sanna, Cinzia ; Del Vecchio, Claudia ; Cannas, Valeria ; Venditti, Alessandro ; Corona, Angela ; Bianco, Armandodoriano ; Serrilli, Anna M. ; Guarcini, Laura ; Parolin, Cristina ; Ballero, Mauro ; Tramontano, Enzo
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Pathogens and disease, 2013-08, Vol.68 (3), p.116-124
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ArticlesPeer ReviewedFull Text
Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem
Author / Creator:Han, Lianyi ; Wang, Yanli ; Bryant, Stephen H
Publisher:England: BioMed Central Ltd
Journal title:BMC bioinformatics, 2008-09, Vol.9 (1), p.401-401, Article 401
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ArticlesPeer ReviewedFull Text
Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals
Author / Creator:Ngcapu, Sinaye ; Theys, Kristof ; Libin, Pieter ; Marconi, Vincent ; Sunpath, Henry ; Ndung’u, Thumbi ; Gordon, Michelle
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2017-11, Vol.9 (11), p.330
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ArticlesPeer ReviewedFull Text
Identification of two HIV inhibitors that also inhibit human RNaseH2
Author / Creator:Kim, J.H., Institut Pasteur Korea, Seongnam, Republic of korea ; Yoon, J.W., Institut Pasteur Korea, Seongnam, Republic of korea ; Ju, M.K., Institut Pasteur Korea, Seongnam, Republic of korea ; Lee, Y.M., Institut Pasteur Korea, Seongnam, Republic of korea ; Kim, T.H., Yonsei University, Seoul, Republic of Korea ; Kim, J.W., Institut Pasteur Korea, Seongnam, Republic of korea ; Sommer, P., Institut Pasteur Korea, Seongnam, Republic of korea ; No, Z.S., Institut Pasteur Korea, Seongnam, Republic of korea ; Cechetto, J., Institut Pasteur Korea, Seongnam, Republic of korea ; Han, S.J., Konkuk University, Seoul, Republic of Korea
Publisher:Dordrecht: Springer Netherlands
Journal title:Molecules and Cells, 2013, 36(3), , pp.212-218
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ArticlesPeer ReviewedFull Text
A Short Hairpin Loop-Structured Oligodeoxynucleotide Targeting the Virion-Associated RNase H of HIV Inhibits HIV Production in Cell Culture and in huPBL-SCID Mice
Author / Creator:Heinrich, Jochen ; Schols, Dominique ; Moelling, Karin
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Intervirology, 2012-01, Vol.55 (3), p.242-246
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ArticlesPeer ReviewedFull Text
Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities
Author / Creator:Tramontano, E. ; Kharlamova, T. ; Zinzula, L. ; Esposito, F.
Publisher:Firenze: Taylor & Francis
Journal title:Journal of chemotherapy (Florence), 2011-10, Vol.23 (5), p.273-276
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Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors

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Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

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The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

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Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

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Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

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Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities

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Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem

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Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals

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Identification of two HIV inhibitors that also inhibit human RNaseH2

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A Short Hairpin Loop-Structured Oligodeoxynucleotide Targeting the Virion-Associated RNase H of HIV Inhibits HIV Production in Cell Culture and in huPBL-SCID Mice

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Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

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