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ArticlesPeer ReviewedFull Text
RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family
Author / Creator:Kourelis, Jiorgos ; Sakai, Toshiyuki ; Adachi, Hiroaki ; Kamoun, Sophien
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2021-10, Vol.19 (10), p.e3001124-e3001124
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ArticlesPeer ReviewedFull Text
An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species
Author / Creator:Adachi, Hiroaki ; Contreras, Mauricio P ; Harant, Adeline ; Wu, Chih-Hang ; Derevnina, Lida ; Sakai, Toshiyuki ; Duggan, Cian ; Moratto, Eleonora ; Bozkurt, Tolga O ; Maqbool, Abbas ; Win, Joe ; Kamoun, Sophien
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-11, Vol.8
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ArticlesPeer ReviewedFull Text
An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana
Author / Creator:Adachi, Hiroaki ; Sakai, Toshiyuki ; Harant, Adeline ; Pai, Hsuan ; Honda, Kodai ; Toghani, AmirAli ; Claeys, Jules ; Duggan, Cian ; Bozkurt, Tolga O ; Wu, Chih-Hang ; Kamoun, Sophien
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2023-01, Vol.19 (1), p.e1010500
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ArticlesPeer ReviewedFull Text
Molecular‐targeting therapies against quantitative abnormalities in gene expression with malignant tumors
Author / Creator:Sakai, Toshiyuki ; Sowa, Yoshihiro
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2017-04, Vol.108 (4), p.570-573
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Newsletter articlesFull Text
European Patent Office Publishes Sakai Toshiyuki and Oncolys Biopharma's Patent Application for Combination Molecularly Targeted Drug for Tumor Therapy and Prevention
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Pharmaceutical Patent News, 2015
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Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells
Author / Creator:Tanaka, Ryoichi ; Tomosugi, Mitsuhiro ; Horinaka, Mano ; Sowa, Yoshihiro ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-05, Vol.10 (5), p.e0125779-e0125779
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Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression
Author / Creator:Umemura, Shiori ; Sowa, Yoshihiro ; Iizumi, Yosuke ; Kitawaki, Jo ; Sakai, Toshiyuki
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2020-06, Vol.111 (6), p.2052-2061
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Identification of c-Met as a novel target of γ-glutamylcyclotransferase
Author / Creator:Saito, Yumiko ; Taniguchi, Keiko ; Ii, Hiromi ; Horinaka, Mano ; Kageyama, Susumu ; Nakata, Susumu ; Ukimura, Osamu ; Sakai, Toshiyuki
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-07, Vol.13 (1), p.11922-11922, Article 11922
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ArticlesPeer ReviewedFull Text
Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)‐reactivating agents enhance efficacy of 5‐fluorouracil on human colon cancer cells
Author / Creator:Watanabe, Motoki ; Sowa, Yoshihiro ; Yogosawa, Mayumi ; Sakai, Toshiyuki
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2013-06, Vol.104 (6), p.687-693
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Newsletter articlesFull Text
Disco Corporation; Patent Application Titled "SiC INGOT FORMING METHOD" Published Online (USPTO 20190152019)
Publisher:Atlanta: NewsRx
Journal title:Asia Business Newsweekly, 2019, p.7691
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ArticlesPeer ReviewedFull Text
Novel RAF/MEK inhibitor CH5126766/VS‐6766 has efficacy in combination with eribulin for the treatment of triple‐negative breast cancer
Author / Creator:Ono, Hisako ; Horinaka, Mano ; Sukeno, Mamiko ; Morita, Mie ; Yasuda, Shusuke ; Nishimoto, Emi ; Konishi, Eiichi ; Sakai, Toshiyuki
Publisher:Tokyo: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-10, Vol.112 (10), p.4166-4175
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ArticlesPeer ReviewedFull Text
The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells
Author / Creator:Wada, Makoto ; Horinaka, Mano ; Yamazaki, Toshikazu ; Katoh, Norito ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-11, Vol.9 (11), p.e113217-e113217
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Newsletter articlesFull Text
WIPO PUBLISHES PATENT OF SAKAI TOSHIYUKI AND ONCOLYS BIOPHARMA FOR "COMBINATION MOLECULARLY TARGETED DRUG FOR TUMOR THERAPY AND PREVENTION" (JAPANESE INVENTOR)
Publisher:Washington, D.C: HT Digital Streams Limited
Journal title:US Fed News Service, Including US State News, 2014
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ArticlesPeer ReviewedFull Text
Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells
Author / Creator:Ichikawa, Masami ; Sowa, Yoshihiro ; Iizumi, Yosuke ; Aono, Yuichi ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-06, Vol.10 (6), p.e0129851-e0129851
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ArticlesPeer ReviewedFull Text
Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2
Author / Creator:Oishi, Masakatsu ; Iizumi, Yosuke ; Taniguchi, Tomoyuki ; Goi, Wakana ; Miki, Tsuneharu ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-02, Vol.8 (2), p.e55922
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ArticlesPeer ReviewedFull Text
xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner
Author / Creator:Miyamoto, Keiko ; Watanabe, Motoki ; Boku, Shogen ; Sukeno, Mamiko ; Morita, Mie ; Kondo, Haruhito ; Sakaguchi, Koichi ; Taguchi, Tetsuya ; Sakai, Toshiyuki
Publisher:Switzerland: MDPI
Journal title:Cancers, 2020-03, Vol.12 (4), p.827
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ArticlesPeer ReviewedFull Text
The Combination of Cigarette Smoking and Alcohol Consumption Synergistically Increases Reactive Carbonyl Species in Human Male Plasma
Author / Creator:Mure, Kanae ; Tomono, Susumu ; Mure, Minae ; Horinaka, Mano ; Mutoh, Michihiro ; Sakai, Toshiyuki ; Ishikawa, Hideki ; Wakabayashi, Keiji
Publisher:Basel: MDPI AG
Journal title:International journal of molecular sciences, 2021-08, Vol.22 (16), p.9043
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γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis
Author / Creator:Taniguchi, Keiko ; Kageyama, Susumu ; Moyama, Chiami ; Ando, Shota ; Ii, Hiromi ; Ashihara, Eishi ; Horinaka, Mano ; Sakai, Toshiyuki ; Kubota, Shigehisa ; Kawauchi, Akihiro ; Nakata, Susumu
Publisher:New York: Nature Publishing Group US
Journal title:Cancer gene therapy, 2022-01, Vol.29 (1), p.37-48
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ArticlesPeer ReviewedFull Text
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
Author / Creator:Nakata, Susumu ; Yoshida, Tatsushi ; Horinaka, Mano ; Shiraishi, Takumi ; Wakada, Miki ; Sakai, Toshiyuki
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2004-08, Vol.23 (37), p.6261-6271
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ArticlesFull Text
Tumor necrosis factor‑related apoptosis‑inducing ligand is a novel transcriptional target of runt‑related transcription factor 1
Author / Creator:Yoshida, Tatsushi ; Yamasaki, Kenta ; Tadagaki, Kenjiro ; Kuwahara, Yasumichi ; Matsumoto, Akifumi ; Sofovic, Adem Ejub ; Kondo, Noriko ; Sakai, Toshiyuki ; Okuda, Tsukasa
Publisher:Athens: Spandidos Publications
Journal title:International journal of oncology, 2022-01, Vol.60 (1), p.1, Article 6
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RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family

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An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

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An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana

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Molecular‐targeting therapies against quantitative abnormalities in gene expression with malignant tumors

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European Patent Office Publishes Sakai Toshiyuki and Oncolys Biopharma's Patent Application for Combination Molecularly Targeted Drug for Tumor Therapy and Prevention

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Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells

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Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression

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Identification of c-Met as a novel target of γ-glutamylcyclotransferase

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Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)‐reactivating agents enhance efficacy of 5‐fluorouracil on human colon cancer cells

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Disco Corporation; Patent Application Titled "SiC INGOT FORMING METHOD" Published Online (USPTO 20190152019)

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Novel RAF/MEK inhibitor CH5126766/VS‐6766 has efficacy in combination with eribulin for the treatment of triple‐negative breast cancer

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The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells

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WIPO PUBLISHES PATENT OF SAKAI TOSHIYUKI AND ONCOLYS BIOPHARMA FOR "COMBINATION MOLECULARLY TARGETED DRUG FOR TUMOR THERAPY AND PREVENTION" (JAPANESE INVENTOR)

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Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells

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Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2

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xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner

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The Combination of Cigarette Smoking and Alcohol Consumption Synergistically Increases Reactive Carbonyl Species in Human Male Plasma

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γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis

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Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

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Tumor necrosis factor‑related apoptosis‑inducing ligand is a novel transcriptional target of runt‑related transcription factor 1

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