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Newsletter articlesFull Text
EpiDestiny Inc, Saunthararajah Yogen, Vadivelu Santhosh, Desimone Joseph and Lau Henry File Patent Application for Compositions Containing Decitabine 5azacytidine and Tetrahydrouridine and Uses Thereo...
Publisher:New Delhi: Athena Information Solutions Pvt. Ltd
Journal title:Indian Patents News, 2020
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ArticlesPeer ReviewedFull Text
Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network
Author / Creator:Gu, Xiaorong ; Tohme, Rita ; Tomlinson, Benjamin ; Sakre, Nneha ; Hasipek, Metis ; Durkin, Lisa ; Schuerger, Caroline ; Grabowski, Dale ; Zidan, Asmaa M. ; Radivoyevitch, Tomas ; Hong, Changjin ; Carraway, Hetty ; Hamilton, Betty ; Sobecks, Ronald ; Patel, Bhumika ; Jha, Babal K. ; Hsi, Eric D. ; Maciejewski, Jaroslaw ; Saunthararajah, Yogen
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-04, Vol.35 (4), p.1023-1036
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ArticlesPeer ReviewedFull Text
Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression
Author / Creator:Stetson, L. C. ; Balasubramanian, Dheepa ; Ribeiro, Susan Pereira ; Stefan, Tammy ; Gupta, Kalpana ; Xu, Xuan ; Fourati, Slim ; Roe, Anne ; Jackson, Zachary ; Schauner, Robert ; Sharma, Ashish ; Tamilselvan, Banumathi ; Li, Samuel ; de Lima, Marcos ; Hwang, Tae Hyun ; Balderas, Robert ; Saunthararajah, Yogen ; Maciejewski, Jaroslaw ; LaFramboise, Thomas ; Barnholtz-Sloan, Jill S. ; Sekaly, Rafick-Pierre ; Wald, David N.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-10, Vol.35 (10), p.2799-2812
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ArticlesPeer ReviewedFull Text
Dynamics of clonal evolution in myelodysplastic syndromes
Author / Creator:Makishima, Hideki ; Yoshizato, Tetsuichi ; Yoshida, Kenichi ; Sekeres, Mikkael A ; Radivoyevitch, Tomas ; Suzuki, Hiromichi ; Przychodzen, Bartlomiej ; Nagata, Yasunobu ; Meggendorfer, Manja ; Sanada, Masashi ; Okuno, Yusuke ; Hirsch, Cassandra ; Kuzmanovic, Teodora ; Sato, Yusuke ; Sato-Otsubo, Aiko ; LaFramboise, Thomas ; Hosono, Naoko ; Shiraishi, Yuichi ; Chiba, Kenichi ; Haferlach, Claudia ; Kern, Wolfgang ; Tanaka, Hiroko ; Shiozawa, Yusuke ; Gómez-Seguí, Inés ; Husseinzadeh, Holleh D ; Thota, Swapna ; Guinta, Kathryn M ; Dienes, Brittney ; Nakamaki, Tsuyoshi ; Miyawaki, Shuichi ; Saunthararajah, Yogen ; Chiba, Shigeru ; Miyano, Satoru ; Shih, Lee-Yung ; Haferlach, Torsten ; Ogawa, Seishi ; Maciejewski, Jaroslaw P
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2017-02, Vol.49 (2), p.204-212
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ArticlesPeer ReviewedFull Text
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
Author / Creator:Banerjee, Shuvojit ; Gusho, Elona ; Gaughan, Christina ; Dong, Beihua ; Gu, Xiaorong ; Holvey-Bates, Elise ; Talukdar, Manisha ; Li, Yize ; Weiss, Susan R. ; Sicheri, Frank ; Saunthararajah, Yogen ; Stark, George R. ; Silverman, Robert H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (11), p.5071-5076
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ArticlesPeer ReviewedFull Text
Large granular lymphocytic leukemia coexists with myeloid clones and myelodysplastic syndrome
Author / Creator:Durrani, Jibran ; Awada, Hassan ; Kishtagari, Ashwin ; Visconte, Valeria ; Kerr, Cassandra ; Adema, Vera ; Nagata, Yasunobu ; Kuzmanovic, Teodora ; Hong, Sanghee ; Patel, Bhumika ; Nazha, Aziz ; Lichtin, Alan ; Mukherjee, Sudipto ; Saunthararajah, Yogen ; Carraway, Hetty ; Sekeres, Mikkael ; Maciejewski, Jaroslaw P.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2020-03, Vol.34 (3), p.957-962
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ArticlesPeer ReviewedFull Text
Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study
Author / Creator:Molokie, Robert ; Lavelle, Donald ; Gowhari, Michel ; Pacini, Michael ; Krauz, Lani ; Hassan, Johara ; Ibanez, Vinzon ; Ruiz, Maria A ; Ng, Kwok Peng ; Woost, Philip ; Radivoyevitch, Tomas ; Pacelli, Daisy ; Fada, Sherry ; Rump, Matthew ; Hsieh, Matthew ; Tisdale, John F ; Jacobberger, James ; Phelps, Mitch ; Engel, James Douglas ; Saraf, Santhosh ; Hsu, Lewis L ; Gordeuk, Victor ; DeSimone, Joseph ; Saunthararajah, Yogen
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2017-09, Vol.14 (9), p.e1002382
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ArticlesPeer ReviewedFull Text
Somatic SETBP1 mutations in myeloid malignancies
Author / Creator:Makishima, Hideki ; Yoshida, Kenichi ; Nguyen, Nhu ; Przychodzen, Bartlomiej ; Sanada, Masashi ; Okuno, Yusuke ; Ng, Kwok Peng ; Gudmundsson, Kristbjorn O ; Vishwakarma, Bandana A ; Jerez, Andres ; Gomez-Segui, Ines ; Takahashi, Mariko ; Shiraishi, Yuichi ; Nagata, Yasunobu ; Guinta, Kathryn ; Mori, Hiraku ; Sekeres, Mikkael A ; Chiba, Kenichi ; Tanaka, Hiroko ; Muramatsu, Hideki ; Sakaguchi, Hirotoshi ; Paquette, Ronald L ; McDevitt, Michael A ; Kojima, Seiji ; Saunthararajah, Yogen ; Miyano, Satoru ; Shih, Lee-Yung ; Du, Yang ; Ogawa, Seishi ; Maciejewski, Jaroslaw P
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2013-08, Vol.45 (8), p.942-946
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ArticlesPeer ReviewedFull Text
Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion
Author / Creator:Chilakala, Sujatha ; Feng, Ye ; Li, Lan ; Mahfouz, Reda ; Quteba, Ebrahem ; Saunthararajah, Yogen ; Xu, Yan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-03, Vol.9 (1), p.4558, Article 4558
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ArticlesPeer ReviewedFull Text
Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia
Author / Creator:Guan, Yihong ; Hasipek, Metis ; Jiang, Dongxu ; Tiwari, Anand D ; Grabowski, Dale R ; Pagliuca, Simona ; Kongkiatkamon, Sunisa ; Patel, Bhumika ; Singh, Salendra ; Parker, Yvonne ; LaFramboise, Thomas ; Lindner, Daniel ; Sekeres, Mikkael A ; Mian, Omar Y ; Saunthararajah, Yogen ; Maciejewski, Jaroslaw P ; Jha, Babal K
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-02, Vol.132 (4), p.1-13
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ArticlesPeer ReviewedFull Text
Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia
Author / Creator:Kongkiatkamon, Sunisa ; Pagliuca, Simona ; Adema, Vera ; Nagata, Yasunobu ; Kerr, Cassandra M. ; Walter, Wencke ; Awada, Hassan ; Hutter, Stephan ; Gurnari, Carmelo ; Rogers, Heesun J. ; Meggendorfer, Manja ; Saunthararajah, Yogen ; Haferlach, Torsten ; Visconte, Valeria ; Maciejewski, Jaroslaw P.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2022-04, Vol.36 (4), p.1185-1188
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ArticlesPeer ReviewedFull Text
Thioredoxin reductase is a major regulator of metabolism in leukemia cells
Author / Creator:Karunanithi, Sheelarani ; Liu, Ruifu ; Hou, Yongchun ; Gonzalez, Giancarlo ; Oldford, Natasha ; Roe, Anne Jessica ; Idipilly, Nethrie ; Gupta, Kalpana ; Amara, Chandra Sekhar ; Putluri, Satwikreddy ; Lee, Grace Kyueun ; Valentin-Goyco, Juan ; Stetson, Lindsay ; Moreton, Stephen A. ; Putluri, Vasanta ; Kavuri, Shyam M. ; Saunthararajah, Yogen ; de Lima, Marcos ; Tochtrop, Gregory P. ; Putluri, Nagireddy ; Wald, David N.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2021-08, Vol.40 (33), p.5236-5246
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ArticlesPeer ReviewedFull Text
Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations
Author / Creator:Awada, Hassan ; Kerr, Cassandra M. ; Durmaz, Arda ; Adema, Vera ; Gurnari, Carmelo ; Pagliuca, Simona ; Zawit, Misam ; Kongkiatkamon, Sunisa ; Rogers, Heesun J. ; Saunthararajah, Yogen ; Sekeres, Mikkael A. ; Carraway, Hetty ; Maciejewski, Jaroslaw P. ; Visconte, Valeria
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-11, Vol.35 (11), p.3324-3328
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ArticlesPeer ReviewedFull Text
Methylation profiles reveal distinct subgroup of hepatocellular carcinoma patients with poor prognosis
Author / Creator:Mah, Way-Champ ; Thurnherr, Thomas ; Chow, Pierce K H ; Chung, Alexander Y F ; Ooi, London L P J ; Toh, Han Chong ; Teh, Bin Tean ; Saunthararajah, Yogen ; Lee, Caroline G L
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-08, Vol.9 (8), p.e104158-e104158
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ArticlesPeer ReviewedFull Text
GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition
Author / Creator:Enane, Francis O ; Shuen, Wai Ho ; Gu, Xiaorong ; Quteba, Ebrahem ; Przychodzen, Bartlomiej ; Makishima, Hideki ; Bodo, Juraj ; Ng, Joanna ; Chee, Chit Lai ; Ba, Rebecca ; Seng Koh, Lip ; Lim, Janice ; Cheong, Rachael ; Teo, Marissa ; Hu, Zhenbo ; Ng, Kwok Peng ; Maciejewski, Jaroslaw ; Radivoyevitch, Tomas ; Chung, Alexander ; Ooi, London Lucien ; Tan, Yu Meng ; Cheow, Peng-Chung ; Chow, Pierce ; Chan, Chung Yip ; Lim, Kiat Hon ; Yerian, Lisa ; Hsi, Eric ; Toh, Han Chong ; Saunthararajah, Yogen
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-09, Vol.127 (9), p.3527-3542
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ArticlesPeer ReviewedFull Text
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
Author / Creator:Guan, Yihong ; Greenberg, Edward F. ; Hasipek, Metis ; Chen, Shi ; Liu, Xiaochen ; Kerr, Cassandra M. ; Gackowski, Daniel ; Zarakowska, Ewelina ; Radivoyevitch, Tomas ; Gu, Xiaorong ; Willard, Belinda ; Visconte, Valeria ; Makishima, Hideki ; Nazha, Aziz ; Mukherji, Mridul ; Sekeres, Mikkael A. ; Saunthararajah, Yogen ; Oliński, Ryszard ; Xu, Mingjiang ; Maciejewski, Jaroslaw P. ; Jha, Babal K.
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2020-09, Vol.3 (1), p.493-493, Article 493
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ArticlesPeer ReviewedFull Text
iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors
Author / Creator:Crabb, John W ; Hu, Bo ; Crabb, John S ; Triozzi, Pierre ; Saunthararajah, Yogen ; Tubbs, Raymond ; Singh, Arun D
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-08, Vol.10 (8), p.e0135543-e0135543
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ArticlesPeer ReviewedFull Text
Oncotherapy resistance explained by Darwinian and Lamarckian models
Author / Creator:Saunthararajah, Yogen
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2024-04, Vol.134 (8)
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ArticlesPeer ReviewedFull Text
Oncotherapy resistance explained by Darwinian and Lamarckian models
Author / Creator:Saunthararajah, Yogen
Publisher:Ann Arbor: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2024-04, Vol.134 (8), p.1-4
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ArticlesPeer ReviewedFull Text
Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma
Author / Creator:Hasipek, Metis ; Grabowski, Dale ; Guan, Yihong ; Alugubelli, Raghunandan Reddy ; Tiwari, Anand D. ; Gu, Xiaorong ; DeAvila, Gabriel A. ; Silva, Ariosto S. ; Meads, Mark B. ; Parker, Yvonne ; Lindner, Daniel J. ; Saunthararajah, Yogen ; Shain, Kenneth H. ; Maciejewski, Jaroslaw P. ; Reu, Frederic J. ; Phillips, James G. ; Jha, Babal K.
Publisher:Basel: MDPI AG
Journal title:Cancers, 2021-05, Vol.13 (11), p.2649
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EpiDestiny Inc, Saunthararajah Yogen, Vadivelu Santhosh, Desimone Joseph and Lau Henry File Patent Application for Compositions Containing Decitabine 5azacytidine and Tetrahydrouridine and Uses Thereo...

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Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

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Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression

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Dynamics of clonal evolution in myelodysplastic syndromes

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OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

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Large granular lymphocytic leukemia coexists with myeloid clones and myelodysplastic syndrome

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Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study

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Somatic SETBP1 mutations in myeloid malignancies

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Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion

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Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia

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Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia

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Thioredoxin reductase is a major regulator of metabolism in leukemia cells

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Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations

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Methylation profiles reveal distinct subgroup of hepatocellular carcinoma patients with poor prognosis

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GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition

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Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

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iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors

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Oncotherapy resistance explained by Darwinian and Lamarckian models

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Oncotherapy resistance explained by Darwinian and Lamarckian models

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Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma

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