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ArticlesPeer ReviewedFull Text
The immunopathology of sepsis and potential therapeutic targets
Author / Creator:van der Poll, Tom ; van de Veerdonk, Frank L. ; Scicluna, Brendon P. ; Netea, Mihai G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2017-07, Vol.17 (7), p.407-420
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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
Author / Creator:Cheng, Shih-Chin ; Scicluna, Brendon P ; Arts, Rob J W ; Gresnigt, Mark S ; Lachmandas, Ekta ; Giamarellos-Bourboulis, Evangelos J ; Kox, Matthijs ; Manjeri, Ganesh R ; Wagenaars, Jori A L ; Cremer, Olaf L ; Leentjens, Jenneke ; van der Meer, Anne J ; van de Veerdonk, Frank L ; Bonten, Marc J ; Schultz, Marcus J ; Willems, Peter H G M ; Pickkers, Peter ; Joosten, Leo A B ; van der Poll, Tom ; Netea, Mihai G
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2016-04, Vol.17 (4), p.406-413
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Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation
Author / Creator:Qin, Wanhai ; Spek, C Arnold ; Scicluna, Brendon P ; van der Poll, Tom ; Duitman, JanWillem
Publisher:England: BioMed Central Ltd
Journal title:Respiratory research, 2022-06, Vol.23 (1), p.162-162, Article 162
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Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
Author / Creator:Qin, Wanhai ; Brands, Xanthe ; Van't Veer, Cornelis ; F de Vos, Alex ; Sirard, Jean-Claude ; J T H Roelofs, Joris ; P Scicluna, Brendon ; van der Poll, Tom
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2021-04, Vol.17 (4), p.e1009491-e1009491
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Isolating high-quality RNA for RNA-Seq from 10-year-old blood samples
Author / Creator:Portelli, Charlene ; Seria, Elisa ; Attard, Ritienne ; Barzine, Mitra ; Esquinas-Roman, Eva M. ; Borg Carbott, Francesca ; Cassar, Karen ; Vella, Matthew ; Scicluna, Brendon P. ; Ebejer, Jean-Paul ; Farrugia, Rosienne ; Bezzina Wettinger, Stephanie
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-12, Vol.14 (1), p.30716-10, Article 30716
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Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients
Author / Creator:Brands, Xanthe ; Uhel, Fabrice ; van Vught, Lonneke A ; Wiewel, Maryse A ; Hoogendijk, Arie J ; Lutter, René ; Schultz, Marcus J ; Scicluna, Brendon P ; van der Poll, Tom
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2022-07, Vol.17 (7), p.e0271637-e0271637
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High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia
Author / Creator:Li, Na ; Zhu, Junhui ; Chen, Peiru ; Bao, Chuntong ; Wang, Jun ; Abdelaal, Tamim ; Chen, Dexi ; Zhu, Sibo ; Wang, Wenjing ; Mao, Jiangnan ; Scicluna, Brendon P ; Koning, Frits ; Li, Fengyang ; Lei, Liancheng
Publisher:England: BioMed Central Ltd
Journal title:Veterinary research (Paris), 2023-09, Vol.54 (1), p.76-76, Article 76
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The leukocyte non-coding RNA landscape in critically ill patients with sepsis
Author / Creator:Scicluna, Brendon P ; Uhel, Fabrice ; van Vught, Lonneke A ; Wiewel, Maryse A ; Hoogendijk, Arie J ; Baessman, Ingelore ; Franitza, Marek ; Nürnberg, Peter ; Horn, Janneke ; Cremer, Olaf L ; Bonten, Marc J ; Schultz, Marcus J ; van der Poll, Tom
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-12, Vol.9
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Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients
Author / Creator:van Vught, Lonneke A ; Scicluna, Brendon P ; Wiewel, Maryse A ; Hoogendijk, Arie J ; Klein Klouwenberg, Peter M C ; Franitza, Marek ; Toliat, Mohammad R ; Nürnberg, Peter ; Cremer, Olaf L ; Horn, Janneke ; Schultz, Marcus J ; Bonten, Marc M J ; van der Poll, Tom
Publisher:United States: American Thoracic Society
Journal title:American journal of respiratory and critical care medicine, 2016-12, Vol.194 (11), p.1366-1374
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The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis
Author / Creator:Khan, Hina N ; Brands, Xanthe ; Aufiero, Simona ; Hoogendijk, Arie J ; Klarenbeek, Augustijn M ; van Engelen, Tjitske S R ; Haak, Bastiaan W ; van Vught, Lonneke A ; Horn, Janneke ; Schultz, Marcus J ; Zwinderman, Aeilko H ; van der Poll, Tom ; Scicluna, Brendon P
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2020-07, Vol.24 (1), p.423-423, Article 423
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Human Adipose‐Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae
Author / Creator:Perlee, Desiree ; Vos, Alex F. ; Scicluna, Brendon P. ; Mancheño, Pablo ; Rosa, Olga ; Dalemans, Wilfried ; Nürnberg, Peter ; Lombardo, Eleuterio ; Poll, Tom
Publisher:Hoboken, USA: John Wiley & Sons, Inc
Journal title:Stem cells translational medicine, 2019-08, Vol.8 (8), p.785-796
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Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications
Author / Creator:Vrijmoeth, Hedwig D ; Ursinus, Jeanine ; Botey-Bataller, Javier ; Kuijpers, Yunus ; Chu, Xiaojing ; van de Schoor, Freek R ; Scicluna, Brendon P ; Xu, Cheng-Jian ; Netea, Mihai G ; Kullberg, Bart Jan ; van den Wijngaard, Cees C ; Li, Yang ; Hovius, Joppe W ; Joosten, Leo A B
Publisher:England: BioMed Central Ltd
Journal title:BMC infectious diseases, 2024-03, Vol.24 (1), p.337-337, Article 337
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An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration
Author / Creator:Brands, Xanthe ; Haak, Bastiaan W ; Klarenbeek, Augustijn M ; Butler, Joe ; Uhel, Fabrice ; Qin, Wanhai ; Otto, Natasja A ; Jakobs, Marja E ; Faber, Daniël R ; Lutter, René ; Wiersinga, W Joost ; van der Poll, Tom ; Scicluna, Brendon P
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2021-08, Vol.13 (1), p.131-131, Article 131
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Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
Author / Creator:Uhel, Fabrice ; Scicluna, Brendon P ; van Vught, Lonneke A ; Cremer, Olaf L ; Bonten, Marc J ; Schultz, Marcus J ; van der Poll, Tom
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2019-06, Vol.23 (1), p.226-226, Article 226
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Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma
Author / Creator:Tekin, Cansu ; Scicluna, Brendon P. ; Lodestijn, Sophie C. ; Shi, Kun ; Bijlsma, Maarten F. ; Spek, C. Arnold
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2021-11, Vol.15 (11), p.3091-3108
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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia
Author / Creator:Schuurman, Alex R ; Reijnders, Tom DY ; Saris, Anno ; Ramirez Moral, Ivan ; Schinkel, Michiel ; de Brabander, Justin ; van Linge, Christine ; Vermeulen, Louis ; Scicluna, Brendon P ; Wiersinga, W Joost ; Vieira Braga, Felipe A ; van der Poll, Tom
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2021-08, Vol.10
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The gut microbiota as a modulator of innate immunity during melioidosis
Author / Creator:Lankelma, Jacqueline M ; Birnie, Emma ; Weehuizen, Tassili A F ; Scicluna, Brendon P ; Belzer, Clara ; Houtkooper, Riekelt H ; Roelofs, Joris J T H ; de Vos, Alex F ; van der Poll, Tom ; Budding, Andries E ; Wiersinga, W Joost
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2017-04, Vol.11 (4), p.e0005548-e0005548
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NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia
Author / Creator:van Lieshout, Miriam H ; Scicluna, Brendon P ; Florquin, Sandrine ; van der Poll, Tom
Publisher:United States: American Thoracic Society
Journal title:American journal of respiratory cell and molecular biology, 2014-04, Vol.50 (4), p.699-712
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Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction
Author / Creator:Lodder, Elisabeth M ; Scicluna, Brendon P ; Milano, Annalisa ; Sun, Albert Y ; Tang, Hao ; Remme, Carol Ann ; Moerland, Perry D ; Tanck, Michael W T ; Pitt, Geoffrey S ; Marchuk, Douglas A ; Bezzina, Connie R
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2012-12, Vol.8 (12), p.e1003113-e1003113
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Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice
Author / Creator:Perlee, Desirée ; de Vos, Alex F ; Scicluna, Brendon P ; Maag, Anja ; Mancheño, Pablo ; de la Rosa, Olga ; Dalemans, Wilfried ; Florquin, Sandrine ; Van't Veer, Cornelis ; Lombardo, Eleuterio ; van der Poll, Tom
Publisher:England: BioMed Central Ltd
Journal title:Stem cell research & therapy, 2019-09, Vol.10 (1), p.286-286, Article 286
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Showing 1 to 20 of 76 results

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The immunopathology of sepsis and potential therapeutic targets

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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

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Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation

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Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

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Isolating high-quality RNA for RNA-Seq from 10-year-old blood samples

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Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients

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High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia

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The leukocyte non-coding RNA landscape in critically ill patients with sepsis

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Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients

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The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis

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Human Adipose‐Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae

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Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications

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An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

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Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

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Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma

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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

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The gut microbiota as a modulator of innate immunity during melioidosis

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NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia

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Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction

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Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice

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