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ArticlesPeer ReviewedFull Text
Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling
Author / Creator:Wojtyniak, Jan‐Georg ; Britz, Hannah ; Selzer, Dominik ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2020-06, Vol.9 (6), p.322-331
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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach
Author / Creator:Fuhr, Laura Maria ; Marok, Fatima Zahra ; Hanke, Nina ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2021-02, Vol.13 (2), p.270
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Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups
Author / Creator:Rüdesheim, Simeon ; Selzer, Dominik ; Fuhr, Uwe ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-04, Vol.11 (4), p.494-511
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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates
Author / Creator:Kovar, Lukas ; Schräpel, Christina ; Selzer, Dominik ; Kohl, Yvonne ; Bals, Robert ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2020-06, Vol.12 (6), p.578
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A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling
Author / Creator:Fuhr, Laura Maria ; Marok, Fatima Zahra ; Mees, Maximilian ; Mahfoud, Felix ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2022-07, Vol.14 (7), p.1474
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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators
Author / Creator:Marok, Fatima Zahra ; Wojtyniak, Jan-Georg ; Fuhr, Laura Maria ; Selzer, Dominik ; Schwab, Matthias ; Weiss, Johanna ; Haefeli, Walter Emil ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2023-02, Vol.15 (2), p.679
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Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network
Author / Creator:Marok, Fatima Zahra ; Fuhr, Laura Maria ; Hanke, Nina ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2021-03, Vol.13 (3), p.331
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In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier
Author / Creator:Kovar, Lukas ; Wien, Lena ; Selzer, Dominik ; Kohl, Yvonne ; Bals, Robert ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceuticals (Basel, Switzerland), 2022-02, Vol.15 (2), p.250
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External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease
Author / Creator:Schräpel, Christina ; Kovar, Lukas ; Selzer, Dominik ; Hofmann, Ute ; Tran, Florian ; Reinisch, Walter ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2021-08, Vol.13 (9), p.1368
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Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates
Author / Creator:Sternjakob-Marthaler, Anna ; Berkó-Göttel, Barbara ; Rissland, Jürgen ; Schöpe, Jakob ; Taurian, Emeline ; Müller, Hanna ; Weber, Gero ; Lohse, Stefan ; Lamberty, Thomas ; Holleczek, Bernd ; Stoffel, Harry ; Hauptmann, Gunter ; Giesen, Martin ; Firk, Christiane ; Schanzenbach, Alexandra ; Brandt, Florian ; Hohmann, Heike ; Werthner, Quirin ; Selzer, Dominik ; Lehr, Thorsten ; Wagenpfeil, Stefan ; Smola, Sigrun
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2022-09, Vol.17 (9), p.e0273332-e0273332
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Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts
Author / Creator:Dings, Christiane ; Götz, Katharina Martha ; Och, Katharina ; Sihinevich, Iryna ; Werthner, Quirin ; Smola, Sigrun ; Bliem, Marc ; Mahfoud, Felix ; Volk, Thomas ; Kreuer, Sascha ; Rissland, Jürgen ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Viruses, 2022-09, Vol.14 (10), p.2114
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Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions
Author / Creator:Rüdesheim, Simeon ; Wojtyniak, Jan-Georg ; Selzer, Dominik ; Hanke, Nina ; Mahfoud, Felix ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2020-12, Vol.12 (12), p.1200
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Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone
Author / Creator:Rüdesheim, Simeon ; Selzer, Dominik ; Mürdter, Thomas ; Igel, Svitlana ; Kerb, Reinhold ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2022-08, Vol.14 (8), p.1734
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Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Predictions
Author / Creator:Loer, Helena Leonie Hanae ; Türk, Denise ; Gómez-Mantilla, José David ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2022-04, Vol.14 (5), p.915
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Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients
Author / Creator:Dings, Christiane ; Meiser, Peter ; Holzer, Frank ; Flegel, Michael ; Selzer, Dominik ; Nagy, Eszter ; Mösges, Ralph ; Klussmann, Jens Peter ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2022-09, Vol.14 (10), p.2059
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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients
Author / Creator:Kovar, Lukas ; Weber, Andreas ; Zemlin, Michael ; Kohl, Yvonne ; Bals, Robert ; Meibohm, Bernd ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2020-09, Vol.12 (10), p.908
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A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions
Author / Creator:Kovar, Christina ; Loer, Helena Leonie Hanae ; Rüdesheim, Simeon ; Fuhr, Laura Maria ; Marok, Fatima Zahra ; Selzer, Dominik ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-07, Vol.13 (7), p.1144-1159
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A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies
Author / Creator:Hanke, Nina ; Türk, Denise ; Selzer, Dominik ; Wiebe, Sabrina ; Fernandez, Éric ; Stopfer, Peter ; Nock, Valerie ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2020-06, Vol.12 (6), p.556
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Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug–drug interaction predictions
Author / Creator:Loer, Helena Leonie Hanae ; Kovar, Christina ; Rüdesheim, Simeon ; Marok, Fatima Zahra ; Fuhr, Laura Maria ; Selzer, Dominik ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-06, Vol.13 (6), p.926-940
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Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network
Author / Creator:Feick, Denise ; Rüdesheim, Simeon ; Marok, Fatima Zahra ; Selzer, Dominik ; Loer, Helena Leonie Hanae ; Teutonico, Donato ; Frechen, Sebastian ; Lee, Maaike ; Moes, Dirk Jan A. R. ; Swen, Jesse J. ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-08, Vol.12 (8), p.1143-1156
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Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

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Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

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A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators

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Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

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In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

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External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

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Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates

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Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts

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Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

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Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Predictions

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Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

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A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions

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A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies

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Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug–drug interaction predictions

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Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network

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