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ArticlesPeer ReviewedFull Text
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells
Author / Creator:Yamawaki, Kouhei ; Shiina, Isamu ; Murata, Takatsugu ; Tateyama, Satoru ; Maekawa, Yutarou ; Niwa, Mariko ; Shimonaka, Motoyuki ; Okamoto, Koji ; Suzuki, Toshihiro ; Nishida, Toshirou ; Abe, Ryo ; Obata, Yuuki
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-11, Vol.11 (1), p.22678-22678, Article 22678
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ArticlesPeer ReviewedFull Text
Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst
Author / Creator:Murata, Takatsugu ; Kawanishi, Tatsuya ; Sekiguchi, Akihiro ; Ishikawa, Ryo ; Ono, Keisuke ; Nakata, Kenya ; Shiina, Isamu
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.2003
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ArticlesPeer ReviewedFull Text
M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells
Author / Creator:Hara, Yasushi ; Obata, Yuuki ; Horikawa, Keita ; Tasaki, Yasutaka ; Suzuki, Kyohei ; Murata, Takatsugu ; Shiina, Isamu ; Abe, Ryo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-04, Vol.12 (4), p.e0175514-e0175514
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ArticlesFull Text
BRAP2 inhibits the Ras/Raf/MEK and PI3K/Akt pathways in leukemia cells, thereby inducing apoptosis and inhibiting cell growth
Author / Creator:Sakai, Hiroharu ; Shiina, Isamu ; Shinomiya, Takahisa ; Nagahara, Yukitoshi
Publisher:Greece: Spandidos Publications
Journal title:Experimental and therapeutic medicine, 2021-05, Vol.21 (5), p.463, Article 463
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ArticlesPeer ReviewedFull Text
Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity
Author / Creator:Tonoi, Takayuki ; Kawahara, Ryo ; Inohana, Takehiko ; Shiina, Isamu
Publisher:London: Nature Publishing Group UK
Journal title:Journal of antibiotics, 2016-09, Vol.69 (9), p.697-701
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ArticlesPeer ReviewedFull Text
A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids
Author / Creator:Tengeiji, Atsushi ; Shiina, Isamu
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2012-06, Vol.17 (6), p.7356-7378
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ArticlesPeer ReviewedFull Text
Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide
Author / Creator:Tonoi, Takayuki ; Inohana, Takehiko ; Sato, Teruyuki ; Noda, Yuuki ; Ikeda, Miyuki ; Akutsu, Miku ; Murata, Takatsugu ; Maekawa, Yutaro ; Tanaka, Anna ; Seki, Rio ; Ohkusu, Misako ; Kamei, Katsuhiko ; Ishiwada, Naruhiko ; Shiina, Isamu
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-09, Vol.24 (19), p.3437
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ArticlesPeer ReviewedFull Text
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells
Author / Creator:Obata, Yuuki ; Hara, Yasushi ; Shiina, Isamu ; Murata, Takatsugu ; Tasaki, Yasutaka ; Suzuki, Kyohei ; Ito, Keiichi ; Tsugawa, Shou ; Yamawaki, Kouhei ; Takahashi, Tsuyoshi ; Okamoto, Koji ; Nishida, Toshirou ; Abe, Ryo
Publisher:England: BioMed Central Ltd
Journal title:Cell communication and signaling, 2019-09, Vol.17 (1), p.114-114, Article 114
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ArticlesPeer ReviewedFull Text
Synthesis of lactones using substituted benzoic anhydride as a coupling reagent
Author / Creator:Shiina, Isamu ; Fukui, Hiroki ; Sasaki, Akane
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2007-10, Vol.2 (10), p.2312-2317
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ArticlesPeer ReviewedFull Text
Induction of mitochondria‐involved apoptosis in estrogen receptor‐negative cells by a novel tamoxifen derivative, ridaifen‐B
Author / Creator:Nagahara, Yukitoshi ; Shiina, Isamu ; Nakata, Kenya ; Sasaki, Akane ; Miyamoto, Tomomi ; Ikekita, Masahiko
Publisher:Melbourne, Australia: Blackwell Publishing Asia
Journal title:Cancer science, 2008-03, Vol.99 (3), p.608-614
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ArticlesPeer ReviewedFull Text
Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction
Author / Creator:Nakata, Kenya ; Sano, Yoshiyuki ; Shiina, Isamu
Publisher:Basel: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2010-10, Vol.15 (10), p.6773-6794
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ArticlesFull Text
Anti‑proliferative effect of ridaifen‑B on hepatoma cells
Author / Creator:Hasegawa, Go ; Akatsuka, Kotomi ; Hiruma, Keita ; Suda, Kayako ; Yokoe, Yumiko ; Mizusawa, Akihito ; Ota, Nozomi ; Shibata, Natsumi ; Tsuchiya, Kaho ; Hayashi, Moyuru ; Shiina, Isamu ; Shimonaka, Motoyuki
Publisher:England: Spandidos Publications
Journal title:Biomedical reports, 2018-08, Vol.9 (2), p.175-180
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ArticlesFull Text
(E)-Selective Weinreb Amide–type Horner–Wadsworth–Emmons Reaction: Effect of Reaction Conditions, Substrate Scope, Isolation of a Reactive Magnesium Phosphonoenolate, and Applications
Publisher:Washington: American Chemical Society
Journal title:ChemRxiv, 2024-05
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ArticlesFull Text
The First Total Synthesis of Tanzawaic Acid B
Publisher:Washington: American Chemical Society
Journal title:ChemRxiv, 2022-12
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ArticlesFull Text
Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells
Author / Creator:Obata, Yuuki ; Kurokawa, Kazuo ; Tojima, Takuro ; Natsume, Miyuki ; Shiina, Isamu ; Takahashi, Tsuyoshi ; Abe, Ryo ; Nakano, Akihiko ; Nishida, Toshirou
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-12
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ArticlesFull Text
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells
Author / Creator:Yamawaki, Kouhei ; Shiina, Isamu ; Murata, Takatsugu ; Tateyama, Satoru ; Maekawa, Yutarou ; Niwa, Mariko ; Shimonaka, Motoyuki ; Okamoto, Koji ; Suzuki, Toshihiro ; Nishida, Toshirou ; Abe, Ryo ; Obata, Yuuki
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2021-01
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FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

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Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst

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M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells

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BRAP2 inhibits the Ras/Raf/MEK and PI3K/Akt pathways in leukemia cells, thereby inducing apoptosis and inhibiting cell growth

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Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity

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A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids

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Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide

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N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

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Synthesis of lactones using substituted benzoic anhydride as a coupling reagent

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Induction of mitochondria‐involved apoptosis in estrogen receptor‐negative cells by a novel tamoxifen derivative, ridaifen‐B

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Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

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Anti‑proliferative effect of ridaifen‑B on hepatoma cells

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(E)-Selective Weinreb Amide–type Horner–Wadsworth–Emmons Reaction: Effect of Reaction Conditions, Substrate Scope, Isolation of a Reactive Magnesium Phosphonoenolate, and Applications

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The First Total Synthesis of Tanzawaic Acid B

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Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

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FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

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