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193 results for Sorger,+Peter+K.

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ArticlesPeer ReviewedFull Text
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
Author / Creator:Hafner, Marc ; Niepel, Mario ; Chung, Mirra ; Sorger, Peter K
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2016-06, Vol.13 (6), p.521-527
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Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method
Author / Creator:Lin, Jia-Ren ; Fallahi-Sichani, Mohammad ; Sorger, Peter K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-09, Vol.6 (1), p.8390-8390, Article 8390
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ArticlesPeer ReviewedFull Text
Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models
Author / Creator:Fröhlich, Fabian ; Sorger, Peter K.
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2022-07, Vol.18 (7), p.e1010322
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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Author / Creator:Lin, Jia-Ren ; Izar, Benjamin ; Wang, Shu ; Yapp, Clarence ; Mei, Shaolin ; Shah, Parin M ; Santagata, Sandro ; Sorger, Peter K
Publisher:England: eLife Sciences Publications, Ltd
Journal title:eLife, 2018-07, Vol.7
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ArticlesPeer ReviewedFull Text
A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity
Author / Creator:Palmer, Adam C ; Chidley, Christopher ; Sorger, Peter K
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-11, Vol.8
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Machine learning identifies candidates for drug repurposing in Alzheimer’s disease
Author / Creator:Rodriguez, Steve ; Hug, Clemens ; Todorov, Petar ; Moret, Nienke ; Boswell, Sarah A. ; Evans, Kyle ; Zhou, George ; Johnson, Nathan T. ; Hyman, Bradley T. ; Sorger, Peter K. ; Albers, Mark W. ; Sokolov, Artem
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1033-13, Article 1033
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ArticlesPeer ReviewedFull Text
Metrics other than potency reveal systematic variation in responses to cancer drugs
Author / Creator:Fallahi-Sichani, Mohammad ; Honarnejad, Saman ; Heiser, Laura M ; Gray, Joe W ; Sorger, Peter K
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2013-11, Vol.9 (11), p.708-714
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ArticlesPeer ReviewedFull Text
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Author / Creator:Fröhlich, Fabian ; Gerosa, Luca ; Muhlich, Jeremy ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2023-02, Vol.19 (2), p.e10988-n/a
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ArticlesPeer ReviewedFull Text
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Author / Creator:Spencer, Sabrina L. ; Gaudet, Suzanne ; Albeck, John G. ; Burke, John M. ; Sorger, Peter K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2009-05, Vol.459 (7245), p.428-432
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Fundamental trade-offs between information flow in single cells and cellular populations
Author / Creator:Suderman, Ryan ; Bachman, John A. ; Smith, Adam ; Sorger, Peter K. ; Deeds, Eric J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (22), p.5755-5760
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Automated assembly of molecular mechanisms at scale from text mining and curated databases
Author / Creator:Bachman, John A ; Gyori, Benjamin M ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2023-05, Vol.19 (5), p.e11325-n/a
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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer
Author / Creator:Färkkilä, Anniina ; Gulhan, Doga C. ; Casado, Julia ; Jacobson, Connor A. ; Nguyen, Huy ; Kochupurakkal, Bose ; Maliga, Zoltan ; Yapp, Clarence ; Chen, Yu-An ; Schapiro, Denis ; Zhou, Yinghui ; Graham, Julie R. ; Dezube, Bruce J. ; Munster, Pamela ; Santagata, Sandro ; Garcia, Elizabeth ; Rodig, Scott ; Lako, Ana ; Chowdhury, Dipanjan ; Shapiro, Geoffrey I. ; Matulonis, Ursula A. ; Park, Peter J. ; Hautaniemi, Sampsa ; Sorger, Peter K. ; Swisher, Elizabeth M. ; D’Andrea, Alan D. ; Konstantinopoulos, Panagiotis A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-03, Vol.11 (1), p.1459-13, Article 1459
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ArticlesPeer ReviewedFull Text
GeneWalk identifies relevant gene functions for a biological context using network representation learning
Author / Creator:Ietswaart, Robert ; Gyori, Benjamin M. ; Bachman, John A. ; Sorger, Peter K. ; Churchman, L. Stirling
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2021-02, Vol.22 (1), p.55-55, Article 55
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ArticlesPeer ReviewedFull Text
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging
Author / Creator:Du, Ziming ; Lin, Jia-Ren ; Rashid, Rumana ; Maliga, Zoltan ; Wang, Shu ; Aster, Jon C. ; Izar, Benjamin ; Sorger, Peter K. ; Santagata, Sandro
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2019-10, Vol.14 (10), p.2900-2930
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ArticlesPeer ReviewedFull Text
From word models to executable models of signaling networks using automated assembly
Author / Creator:Gyori, Benjamin M ; Bachman, John A ; Subramanian, Kartik ; Muhlich, Jeremy L ; Galescu, Lucian ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2017-11, Vol.13 (11), p.954-n/a
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ArticlesPeer ReviewedFull Text
HSF1 phase transition mediates stress adaptation and cell fate decisions
Author / Creator:Gaglia, Giorgio ; Rashid, Rumana ; Yapp, Clarence ; Joshi, Gaurav N. ; Li, Carmen G. ; Lindquist, Susan L. ; Sarosiek, Kristopher A. ; Whitesell, Luke ; Sorger, Peter K. ; Santagata, Sandro
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2020-02, Vol.22 (2), p.151-158
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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state
Author / Creator:Fallahi‐Sichani, Mohammad ; Becker, Verena ; Izar, Benjamin ; Baker, Gregory J ; Lin, Jia‐Ren ; Boswell, Sarah A ; Shah, Parin ; Rotem, Asaf ; Garraway, Levi A ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2017-01, Vol.13 (1), p.905-n/a
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ArticlesPeer ReviewedFull Text
Programming biological models in Python using PySB
Author / Creator:Lopez, Carlos F ; Muhlich, Jeremy L ; Bachman, John A ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2013, Vol.9 (1), p.646-n/a
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ArticlesPeer ReviewedFull Text
Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects
Author / Creator:Plana, Deborah ; Fell, Geoffrey ; Alexander, Brian M. ; Palmer, Adam C. ; Sorger, Peter K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.873-873, Article 873
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ArticlesPeer ReviewedFull Text
Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold
Author / Creator:Roux, Jérémie ; Hafner, Marc ; Bandara, Samuel ; Sims, Joshua J ; Hudson, Hannah ; Chai, Diana ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2015-05, Vol.11 (5), p.803-n/a
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Showing 1 to 20 of 193 results

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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

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Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method

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Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models

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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

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A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

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Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

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Metrics other than potency reveal systematic variation in responses to cancer drugs

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Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

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Fundamental trade-offs between information flow in single cells and cellular populations

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Automated assembly of molecular mechanisms at scale from text mining and curated databases

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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer

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GeneWalk identifies relevant gene functions for a biological context using network representation learning

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Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging

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From word models to executable models of signaling networks using automated assembly

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HSF1 phase transition mediates stress adaptation and cell fate decisions

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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

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Programming biological models in Python using PySB

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Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects

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Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold

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