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Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Author / Creator:Ehninger, Dan ; Han, Sangyeul ; Shilyansky, Carrie ; Zhou, Yu ; Li, Weidong ; Kwiatkowski, David J ; Ramesh, Vijaya ; Silva, Alcino J
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2008-08, Vol.14 (8), p.843-848
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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
Author / Creator:Ranek, Mark J. ; Kokkonen-Simon, Kristen M. ; Chen, Anna ; Dunkerly-Eyring, Brittany L. ; Vera, Miguel Pinilla ; Oeing, Christian U. ; Patel, Chirag H. ; Nakamura, Taishi ; Zhu, Guangshuo ; Bedja, Djahida ; Sasaki, Masayuki ; Holewinski, Ronald J. ; Van Eyk, Jennifer E. ; Powell, Jonathan D. ; Lee, Dong Ik ; Kass, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-02, Vol.566 (7743), p.264-269
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Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status
Author / Creator:Marqués, Patricia ; Burillo, Jesús ; González-Blanco, Carlos ; Jiménez, Beatriz ; García, Gema ; García-Aguilar, Ana ; Iglesias-Fortes, Sarai ; Lockwood, Ángela ; Guillén, Carlos
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-05, Vol.14 (1), p.12521-13, Article 12521
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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
Author / Creator:Alesi, Nicola ; Akl, Elie W. ; Khabibullin, Damir ; Liu, Heng-Jia ; Nidhiry, Anna S. ; Garner, Emma R. ; Filippakis, Harilaos ; Lam, Hilaire C. ; Shi, Wei ; Viswanathan, Srinivas R. ; Morroni, Manrico ; Ferguson, Shawn M. ; Henske, Elizabeth P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-07, Vol.12 (1), p.4245-12, Article 4245
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The role of TSC1 and TSC2 proteins in neuronal axons
Author / Creator:Karalis, Vasiliki ; Wood, Delaney ; Teaney, Nicole A ; Sahin, Mustafa
Publisher:New York: Nature Publishing Group
Journal title:Molecular psychiatry, 2024-04, Vol.29 (4), p.1165-1178
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Presynaptic GABAB receptor–mediated network excitation in the medial prefrontal cortex of Tsc2+/- mice
Author / Creator:Bassetti, Davide ; Luhmann, Heiko J. ; Kirischuk, Sergei
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Pflügers Archiv, 2021-08, Vol.473 (8), p.1261-1271
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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
Author / Creator:Tyburczy, Magdalena E. ; Dies, Kira A. ; Glass, Jennifer ; Camposano, Susana ; Chekaluk, Yvonne ; Thorner, Aaron R. ; Lin, Ling ; Krueger, Darcy ; Franz, David N. ; Thiele, Elizabeth A. ; Sahin, Mustafa ; Kwiatkowski, David J.
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2015-11, Vol.11 (11), p.e1005637-e1005637
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Author / Creator:Alexander, Angela ; Cai, Sheng-Li ; Kim, Jinhee ; Nanez, Adrian ; Sahin, Mustafa ; MacLean, Kirsteen H ; Inoki, Ken ; Guan, Kun-Liang ; Shen, Jianjun ; Person, Maria D ; Kusewitt, Donna ; Mills, Gordon B ; Kastan, Michael B ; Walker, Cheryl Lyn
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (9), p.4153-4158
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Lysosomal recruitment of TSC2 is a universal response to cellular stress
Author / Creator:Demetriades, Constantinos ; Plescher, Monika ; Teleman, Aurelio A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-02, Vol.7 (1), p.10662-14, Article 10662
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Tumor‐derived exosomal miR‐148b‐3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion
Author / Creator:Hao, Chong ; Sheng, Zhimei ; Wang, Wenhao ; Feng, Ruijun ; Zheng, Yuanhang ; Xiao, Qinpei ; Zhang, Baogang
Publisher:Melbourne: John Wiley & Sons Australia, Ltd
Journal title:Thoracic cancer, 2023-06, Vol.14 (16), p.1477-1491
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Akt regulates growth by directly phosphorylating Tsc2
Author / Creator:Potter, Christopher J. ; Pedraza, Laura G. ; Xu, Tian
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2002-09, Vol.4 (9), p.658-665
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Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease
Author / Creator:Liang, Xiaomei ; Zeng, Yaqi ; Zhang, Piao ; Zhu, Baoyu ; Feng, Jiezhu ; Deng, Tongtong ; Fu, Zhongling ; Liu, Chengshuai ; Chen, Chengyu ; Zhang, Yuhu
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2025-06, Vol.23 (1), p.631-25, Article 631
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TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study
Author / Creator:Ogórek, Barbara ; Hamieh, Lana ; Hulshof, Hanna M. ; Lasseter, Kathryn ; Klonowska, Katarzyna ; Kuijf, Hugo ; Moavero, Romina ; Hertzberg, Christoph ; Weschke, Bernhard ; Riney, Kate ; Feucht, Martha ; Scholl, Theresa ; Krsek, Pavel ; Nabbout, Rima ; Jansen, Anna C. ; Benova, Barbora ; Aronica, Eleonora ; Lagae, Lieven ; Curatolo, Paolo ; Borkowska, Julita ; Sadowski, Krzysztof ; Domańska-Pakieła, Dorota ; Janson, Stef ; Kozlowski, Piotr ; Urbanska, Malgorzata ; Jaworski, Jacek ; Jozwiak, Sergiusz ; Jansen, Floor E. ; Kotulska, Katarzyna ; Kwiatkowski, David J.
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2020-09, Vol.22 (9), p.1489-1497
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The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR
Author / Creator:Johannessen, Cory M. ; Reczek, Elizabeth E. ; James, Marianne F. ; Brems, Hilde ; Legius, Eric ; Cichowski, Karen ; Cantley, Lewis C.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (24), p.8573-8578
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Commentary on: Bassetti, D., Luhmann, H.J., Kirischuk, S. Presynaptic GABAB receptor-mediated network excitation in the medial prefrontal cortex of Tsc2 + / − mice
Author / Creator:Alzheimer, Christian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Pflügers Archiv, 2021-08, Vol.473 (8), p.1171-1172
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Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma
Author / Creator:Calsina, Bruna ; Castro-Vega, Luis Jaime ; Torres-Pérez, Rafael ; Inglada-Pérez, Lucía ; Currás-Freixes, Maria ; Roldán-Romero, Juan María ; Mancikova, Veronika ; Letón, Rocío ; Remacha, Laura ; Santos, María ; Burnichon, Nelly ; Lussey-Lepoutre, Charlotte ; Rapizzi, Elena ; Graña, Osvaldo ; Álvarez-Escolá, Cristina ; de Cubas, Aguirre A ; Lanillos, Javier ; Cordero-Barreal, Alfonso ; Martínez-Montes, Ángel M ; Bellucci, Alexandre ; Amar, Laurence ; Fernandes-Rosa, Fabio Luiz ; Calatayud, María ; Aller, Javier ; Lamas, Cristina ; Sastre-Marcos, Júlia ; Canu, Letizia ; Korpershoek, Esther ; Timmers, Henri J ; Lenders, Jacques WM ; Beuschlein, Felix ; Fassnacht-Capeller, Martin ; Eisenhofer, Graeme ; Mannelli, Massimo ; Al-Shahrour, Fátima ; Favier, Judith ; Rodríguez-Antona, Cristina ; Cascón, Alberto ; Montero-Conde, Cristina ; Gimenez-Roqueplo, Anne-Paule ; Robledo, Mercedes
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2019-01, Vol.9 (17), p.4946-4958
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Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype – phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex
Author / Creator:Sancak, Ozgur ; Nellist, Mark ; Goedbloed, Miriam ; Elfferich, Peter ; Wouters, Cokkie ; Maat-Kievit, Anneke ; Zonnenberg, Bernard ; Verhoef, Senno ; Halley, Dicky ; van den Ouweland, Ans
Publisher:Cham: Springer International Publishing
Journal title:European journal of human genetics : EJHG, 2005-06, Vol.13 (6), p.731-741
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Splicing Analysis of Exonic TSC1 and TSC2 Gene Variants Causing Tuberous Sclerosis Complex
Author / Creator:You, Qingqing ; Liu, Jingwei ; Zhang, Ran ; Wang, Zhi ; Zhang, Bingying ; Guo, Wencong ; Xu, Ning ; Bottillo, Irene ; Shao, Leping
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:Human mutation, 2025-01, Vol.2025
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ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
Author / Creator:Liu, Mingdong ; Zeng, Taoling ; Zhang, Xin ; Liu, Chunyan ; Wu, Zhihui ; Yao, Luming ; Xie, Changchuan ; Xia, Hui ; Lin, Qi ; Xie, Liping ; Zhou, Dawang ; Deng, Xianming ; Hong-Lin, Chan ; Tong-Jin, Zhao ; Hong-Rui, Wang
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-10, Vol.9, p.1-14
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Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes
Author / Creator:Ansari, Mohammad Y. ; Ahmad, Nashrah ; Haqqi, Tariq M.
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Cellular physiology and biochemistry, 2018-01, Vol.49 (3), p.932-946
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Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

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Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status

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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

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The role of TSC1 and TSC2 proteins in neuronal axons

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Presynaptic GABAB receptor–mediated network excitation in the medial prefrontal cortex of Tsc2+/- mice

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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Lysosomal recruitment of TSC2 is a universal response to cellular stress

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Tumor‐derived exosomal miR‐148b‐3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion

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Akt regulates growth by directly phosphorylating Tsc2

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Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

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TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study

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The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR

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Commentary on: Bassetti, D., Luhmann, H.J., Kirischuk, S. Presynaptic GABAB receptor-mediated network excitation in the medial prefrontal cortex of Tsc2 + / − mice

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Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma

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Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype – phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex

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Splicing Analysis of Exonic TSC1 and TSC2 Gene Variants Causing Tuberous Sclerosis Complex

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ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

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Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes

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