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ArticlesPeer ReviewedFull Text
Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two...
Author / Creator:Novak, Gerald ; Streffer, Johannes Rolf ; Timmers, Maarten ; Henley, David ; Brashear, H Robert ; Bogert, Jennifer ; Russu, Alberto ; Janssens, Luc ; Tesseur, Ina ; Tritsmans, Luc ; Van Nueten, Luc ; Engelborghs, Sebastiaan
Publisher:England: BioMed Central Ltd
Journal title:Alzheimer's research & therapy, 2020-05, Vol.12 (1), p.58-58, Article 58
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Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study
Author / Creator:Timmers, Maarten ; Streffer, Johannes Rolf ; Russu, Alberto ; Tominaga, Yushin ; Shimizu, Hiroko ; Shiraishi, Ayako ; Tatikola, Kanaka ; Smekens, Pascale ; Börjesson-Hanson, Anne ; Andreasen, Niels ; Matias-Guiu, Jorge ; Baquero, Miquel ; Boada, Mercè ; Tesseur, Ina ; Tritsmans, Luc ; Van Nueten, Luc ; Engelborghs, Sebastiaan
Publisher:England: BioMed Central Ltd
Journal title:Alzheimer's research & therapy, 2018-08, Vol.10 (1), p.85-85, Article 85
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Regulation of amyloid precursor protein processing by serotonin signaling
Author / Creator:Pimenova, Anna A ; Thathiah, Amantha ; De Strooper, Bart ; Tesseur, Ina
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-01, Vol.9 (1), p.e87014-e87014
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Carboxyl-Terminal-Truncated Apolipoprotein E4 Causes Alzheimer's Disease-like Neurodegeneration and Behavioral Deficits in Transgenic Mice
Author / Creator:Harris, Faith M. ; Brecht, Walter J. ; Xu, Qin ; Tesseur, Ina ; Kekonius, Lisa ; Wyss-Coray, Tony ; Fish, Jo Dee ; Masliah, Eliezer ; Hopkins, Paul C. ; Scearce-Levie, Kimberly ; Weisgraber, Karl H. ; Mucke, Lennart ; Mahley, Robert W. ; Huang, Yadong
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (19), p.10966-10971
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Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons
Author / Creator:Van Dorpe, Jo ; Smeijers, Liesbet ; Dewachter, Ilse ; Nuyens, Dieter ; Spittaels, Kurt ; Van den Haute, Chris ; Mercken, Marc ; Moechars, Dieder ; Laenen, Isabelle ; Kuiperi, Cuno ; Bruynseels, Koen ; Tesseur, Ina ; Loos, Ruth ; Vanderstichele, Hugo ; Checler, Frédéric ; Sciot, Raf ; Van Leuven, Fred
Publisher:Bethesda, MD: Elsevier Inc
Journal title:The American journal of pathology, 2000-10, Vol.157 (4), p.1283-1298
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Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord
Author / Creator:Tesseur, Ina ; Van Dorpe, Jo ; Bruynseels, Koen ; Bronfman, Francisca ; Sciot, Raf ; Van Lommel, Alfons ; Van Leuven, Fred
Publisher:Bethesda, MD: Elsevier Inc
Journal title:The American journal of pathology, 2000-11, Vol.157 (5), p.1495-1510
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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
Author / Creator:Tesseur, Ina ; Lo, Adrian C ; Roberfroid, Anouk ; Dietvorst, Sofie ; Van Broeck, Bianca ; Borgers, Marianne ; Gijsen, Harrie ; Moechars, Diederik ; Mercken, Marc ; Kemp, John ; D'Hooge, Rudi ; De Strooper, Bart
Publisher:United States
Journal title:Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6135), p.924-924
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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
Author / Creator:Tesseur, Ina ; Zou, Kun ; Esposito, Luke ; Bard, Frederique ; Berber, Elisabeth ; Can, Judith Van ; Lin, Amy H ; Crews, Leslie ; Tremblay, Patrick ; Mathews, Paul ; Mucke, Lennart ; Masliah, Eliezer ; Wyss-Coray, Tony
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2006-11, Vol.116 (11), p.3060-3069
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When the dust settles: what did we learn from the bexarotene discussion?
Author / Creator:Tesseur, Ina ; De Strooper, Bart
Publisher:England: BioMed Central
Journal title:Alzheimer's research & therapy, 2013-01, Vol.5 (6), p.54-54
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Collagen VI protects neurons against Aβ toxicity
Author / Creator:Cheng, Jason S ; Dubal, Dena B ; Kim, Daniel H ; Legleiter, Justin ; Cheng, Irene H ; Yu, Gui-Qiu ; Tesseur, Ina ; Wyss-Coray, Tony ; Bonaldo, Paolo ; Mucke, Lennart
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2009-02, Vol.12 (2), p.119-121
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ArticlesPeer ReviewedFull Text
Comment on "ApoE-Directed Therapeutics Rapidly Clear [beta]-Amyloid and Reverse Deficits in AD Mouse Models": 2
Author / Creator:Tesseur, Ina ; Lo, Adrian C ; Roberfroid, Anouk ; Dietvorst, Sofie ; Bianca Van Broeck ; Borgers, Marianne ; Gijsen, Harrie ; Moechars, Diederik ; Mercken, Marc ; Kemp, John ; D'Hooge, Rudi ; De Strooper, Bart
Publisher:Washington: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6135), p.924
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ArticlesPeer ReviewedFull Text
Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice
Author / Creator:Tesseur, Ina ; Van Dorpe, Jo ; Spittaels, Kurt ; Van den Haute, Chris ; Moechars, Dieder ; Van Leuven, Fred
Publisher:Bethesda, MD: Elsevier Inc
Journal title:The American journal of pathology, 2000-03, Vol.156 (3), p.951-964
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Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs
Author / Creator:Tesseur, Ina ; Lo, Adrian ; Roberfroid, Anouk ; Dietvorst, Sofie ; Van Broeck, Bianca ; Borgers, Marianne ; Gijsen, Harrie ; Moechars, Diederik ; Mercken, Marc ; Kemp, John ; D’Hooge, Rudi ; De Strooper, Bart
Publisher:BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2013-09, Vol.8 (Suppl 1), p.P40-P40
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Deficiency in neuronal TGF-[beta] signaling promotes neurodegeneration and Alzheimer's pathology
Author / Creator:Tesseur, Ina ; Zou, Kun ; Esposito, Luke ; Bard, Frederique
Publisher:Ann Arbor: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2006-11, Vol.116 (11), p.3060
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ArticlesPeer ReviewedFull Text
Collagen VI protects neurons against A[beta] toxicity
Author / Creator:Cheng, Jason S ; Dubal, Dena B ; Kim, Daniel H ; Legleiter, Justin ; Cheng, Irene H ; Yu, Gui-qiu ; Tesseur, Ina ; Wyss-coray, Tony ; Bonaldo, Paolo ; Mucke, Lennart
Publisher:New York: Nature Publishing Group
Journal title:Nature neuroscience, 2009-02, Vol.12 (2), p.119
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ArticlesPeer ReviewedFull Text
Bexarotene treatment does not clear [beta]-Amyloid in an AD mouse model and Beagle dogs
Author / Creator:Tesseur, Ina ; Lo, Adrian ; Roberfroid, Anouk ; Dietvorst, Sofie ; Van Broeck, Bianca ; Borgers, Marianne ; Gijsen, Harrie ; Moechars, Diederik ; Mercken, Marc ; Kemp, John ; D'Hooge, Rudi ; De Strooper, Bart
Publisher:London: BioMed Central
Journal title:Molecular neurodegeneration, 2013-01, Vol.8 (Suppl 1)
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ArticlesPeer ReviewedFull Text
Collagen VI protects neurons against Abeta toxicity
Author / Creator:Cheng, Jason S ; Dubal, Dena B ; Kim, Daniel H ; Legleiter, Justin ; Cheng, Irene H ; Yu, Gui-Qiu ; Tesseur, Ina ; Wyss-Coray, Tony ; Bonaldo, Paolo ; Mucke, Lennart
Publisher:United States
Journal title:Nature neuroscience, 2009-02, Vol.12 (2), p.119
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ReportsFull Text
Long-term safety and tolerability of atabecestat , an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extens...
Author / Creator:Novak, Gerald ; Streffer, Johannes Rolf ; Timmers, Maarten ; Henley, David ; Brashear, H. Robert ; Bogert, Jennifer ; Russu, Alberto ; Janssens, Luc ; Tesseur, Ina ; Tritsmans, Luc ; Van Nueten, Luc ; Engelborghs, Sebastiaan
Publisher:BioMed Central Ltd
Journal title:Alzheimer's Research & Therapy, 2020, Vol.12 (1)
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ReportsFull Text
Pharmacodynamics of atabecestat , an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study
Author / Creator:Timmers, Maarten ; Streffer, Johannes Rolf ; Russu, Alberto ; Tominaga, Yushin ; Shimizu, Hiroko ; Shiraishi, Ayako ; Tatikola, Kanaka ; Smekens, Pascale ; Börjesson-Hanson, Anne ; Andreasen, Niels ; Matias-Guiu, Jorge ; Baquero, Miquel ; Boada, Mercè ; Tesseur, Ina ; Tritsmans, Luc ; Van Nueten, Luc ; Engelborghs, Sebastiaan
Publisher:BioMed Central Ltd
Journal title:Alzheimer's Research & Therapy, 2018, Vol.10 (1)
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Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two...

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Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study

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Regulation of amyloid precursor protein processing by serotonin signaling

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Carboxyl-Terminal-Truncated Apolipoprotein E4 Causes Alzheimer's Disease-like Neurodegeneration and Behavioral Deficits in Transgenic Mice

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Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

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Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord

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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

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When the dust settles: what did we learn from the bexarotene discussion?

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Collagen VI protects neurons against Aβ toxicity

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Comment on "ApoE-Directed Therapeutics Rapidly Clear [beta]-Amyloid and Reverse Deficits in AD Mouse Models": 2

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Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

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Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs

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Deficiency in neuronal TGF-[beta] signaling promotes neurodegeneration and Alzheimer's pathology

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Collagen VI protects neurons against A[beta] toxicity

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Bexarotene treatment does not clear [beta]-Amyloid in an AD mouse model and Beagle dogs

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Collagen VI protects neurons against Abeta toxicity

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Long-term safety and tolerability of atabecestat , an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extens...

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Pharmacodynamics of atabecestat , an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study

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