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Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis
Author / Creator:Chen, Lin ; Ishigami, Tomoaki ; Doi, Hiroshi ; Arakawa, Kentaro ; Tamura, Kouichi
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Journal of molecular medicine (Berlin, Germany), 2020-09, Vol.98 (9), p.1235-1244
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Analysis of clinical factors associated with Kampo formula-induced pseudoaldosteronism based on self-reported information from the Japanese Adverse Drug Event Report database
Author / Creator:Uneda, Kazushi ; Kawai, Yuki ; Kaneko, Akira ; Kayo, Takumi ; Akiba, Shuichiro ; Ishigami, Tomoaki ; Yoshida-Komiya, Hiromi ; Suzuki, Masao ; Mitsuma, Tadamichi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-01, Vol.19 (1), p.e0296450
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Japanese traditional Kampo medicine bofutsushosan improves body mass index in participants with obesity: A systematic review and meta-analysis
Author / Creator:Uneda, Kazushi ; Kawai, Yuki ; Yamada, Takayuki ; Kaneko, Akira ; Saito, Ryuji ; Chen, Lin ; Ishigami, Tomoaki ; Namiki, Takao ; Mitsuma, Tadamichi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-04, Vol.17 (4), p.e0266917
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Relationship between changes in blood pressure from summer to winter and estimated 24-hour salt excretion using spot urine: the Niigata Wellness Study
Author / Creator:Kato, Kiminori ; Ishigami, Tomoaki ; Kobayashi, Takashi ; Tahiro, Minoru ; Tashiro, Shigemi ; Yamada, Takaho ; Iwanaga, Midori ; Kodama, Satoru ; Fujihara, Kazuya ; Sato, Koji ; Sone, Hirohito
Publisher:England: Nature Publishing Group
Journal title:Hypertension research, 2023-01, Vol.46 (1), p.226-230
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Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI
Author / Creator:Matsuzawa, Yasushi ; Nakahashi, Hidefumi ; Konishi, Masaaki ; Sato, Ryosuke ; Kawashima, Chika ; Kikuchi, Shinnosuke ; Akiyama, Eiichi ; Iwahashi, Noriaki ; Maejima, Nobuhiko ; Okada, Kozo ; Ebina, Toshiaki ; Hibi, Kiyoshi ; Kosuge, Masami ; Ishigami, Tomoaki ; Tamura, Kouichi ; Kimura, Kazuo
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-08, Vol.9 (1), p.11647-11, Article 11647
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Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
Author / Creator:Narikawa, Masatoshi ; Umemura, Masanari ; Tanaka, Ryo ; Hikichi, Mayu ; Nagasako, Akane ; Fujita, Takayuki ; Yokoyama, Utako ; Ishigami, Tomoaki ; Kimura, Kazuo ; Tamura, Kouichi ; Ishikawa, Yoshihiro
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-09, Vol.14 (9), p.e0221940
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Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice
Author / Creator:Azushima, Kengo ; Uneda, Kazushi ; Wakui, Hiromichi ; Ohki, Kohji ; Haruhara, Kotaro ; Kobayashi, Ryu ; Haku, Sona ; Kinguchi, Sho ; Yamaji, Takahiro ; Minegishi, Shintaro ; Ishigami, Tomoaki ; Yamashita, Akio ; Tamura, Kouichi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-04, Vol.9 (1), p.6201, Article 6201
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The effectiveness of a Kampo e-learning course incorporated into the medical education curriculum: a possible solution to instructor shortages and time constraints
Author / Creator:Nakada, Yoshinobu ; Arai, Makoto ; Yamato, Ippei ; Nogami, Tatsuya ; Odaguchi, Hiroshi ; Taniguchi, Daigo ; Tomita, Jun ; Ishigami, Tomoaki
Publisher:England: BioMed Central Ltd
Journal title:BMC medical education, 2025-02, Vol.25 (1), p.299-7, Article 299
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Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice
Author / Creator:Arakawa, Kentaro ; Ishigami, Tomoaki ; Nakai-Sugiyama, Michiko ; Chen, Lin ; Doi, Hiroshi ; Kino, Tabito ; Minegishi, Shintaro ; Saigoh-Teranaka, Sae ; Sasaki-Nakashima, Rie ; Hibi, Kiyoshi ; Kimura, Kazuo ; Tamura, Kouichi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-06, Vol.14 (6), p.e0218096
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Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products
Author / Creator:Saigo, Sae ; Kino, Tabito ; Uchida, Kotaro ; Sugawara, Takuya ; Chen, Lin ; Sugiyama, Michiko ; Azushima, Kengo ; Wakui, Hiromichi ; Tamura, Kouichi ; Ishigami, Tomoaki
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-12, Vol.23 (1), p.302
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ArticlesPeer ReviewedFull Text
Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
Author / Creator:Tanaka, Shohei ; Wakui, Hiromichi ; Azushima, Kengo ; Tsukamoto, Shunichiro ; Yamaji, Takahiro ; Urate, Shingo ; Suzuki, Toru ; Abe, Eriko ; Taguchi, Shinya ; Yamada, Takayuki ; Kobayashi, Ryu ; Kanaoka, Tomohiko ; Kamimura, Daisuke ; Kinguchi, Sho ; Takiguchi, Masahito ; Funakoshi, Kengo ; Yamashita, Akio ; Ishigami, Tomoaki ; Tamura, Kouichi
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-04, Vol.24 (9), p.7778
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Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling
Author / Creator:Narikawa, Masatoshi ; Umemura, Masanari ; Tanaka, Ryo ; Fujita, Takayuki ; Yokoyama, Utako ; Ishigami, Tomoaki ; Kimura, Kazuo ; Tamura, Kouichi ; Ishikawa, Yoshihiro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-04, Vol.8 (1), p.6277-11, Article 6277
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Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation
Author / Creator:Tanaka, Ryo ; Umemura, Masanari ; Narikawa, Masatoshi ; Hikichi, Mayu ; Osaw, Kohei ; Fujita, Takayuki ; Yokoyama, Utako ; Ishigami, Tomoaki ; Tamura, Kouichi ; Ishikawa, Yoshihiro
Publisher:England: John Wiley & Sons, Inc
Journal title:ESC Heart Failure, 2020-04, Vol.7 (2), p.588-603
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Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension
Author / Creator:Ishigami, Tomoaki ; Kino, Tabito ; Minegishi, Shintaro ; Araki, Naomi ; Umemura, Masanari ; Ushio, Hisako ; Saigoh, Sae ; Sugiyama, Michiko
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-05, Vol.21 (11), p.3871
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Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice
Author / Creator:Wakui, Hiromichi ; Yamaji, Takahiro ; Azushima, Kengo ; Uneda, Kazushi ; Haruhara, Kotaro ; Nakamura, Akiko ; Ohki, Kohji ; Kinguchi, Sho ; Kobayashi, Ryu ; Urate, Shingo ; Suzuki, Toru ; Kamimura, Daisuke ; Minegishi, Shintaro ; Ishigami, Tomoaki ; Kanaoka, Tomohiko ; Matsuo, Kohei ; Miyazaki, Tomoyuki ; Fujikawa, Tetsuya ; Yamashita, Akio ; Tamura, Kouichi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-02, Vol.10 (1), p.1782-11, Article 1782
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The Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease
Author / Creator:Chen, Lin ; Ishigami, Tomoaki ; Doi, Hiroshi ; Arakawa, Kentaro ; Tamura, Kouichi
Publisher:Switzerland: MDPI AG
Journal title:Journal of Clinical Medicine, 2021-07, Vol.10 (14), p.3120
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Clinical impact of left ventricular systolic dysfunction in patients undergoing dialysis access surgery
Author / Creator:Saka, Sanae ; Konishi, Masaaki ; Kamimura, Daisuke ; Wakui, Hiromichi ; Matsuzawa, Yasushi ; Okada, Kozo ; Kirigaya, Jin ; Iwahashi, Noriaki ; Sugano, Teruyasu ; Ishigami, Tomoaki ; Hirawa, Nobuhito ; Hibi, Kiyoshi ; Ebina, Toshiaki ; Kimura, Kazuo ; Tamura, Kouichi
Publisher:Tokyo: Springer Nature B.V
Journal title:Clinical and experimental nephrology, 2023-04, Vol.27 (4), p.374-381
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A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-t...
Author / Creator:Takayama, Shin ; Namiki, Takao ; Ito, Takashi ; Arita, Ryutaro ; Nakae, Hajime ; Kobayashi, Seiichi ; Yoshino, Tetsuhiro ; Ishigami, Tomoaki ; Tanaka, Koichiro ; Kainuma, Mosaburo ; Nochioka, Kotaro ; Takagi, Airi ; Mimura, Masaru ; Yamaguchi, Takuhiro ; Ishii, Tadashi
Publisher:England: BioMed Central Ltd
Journal title:Current controlled trials in cardiovascular medicine, 2020-10, Vol.21 (1), p.827-3, Article 827
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AI-Induced Vascular Ages Are a Measurable Residual Risk for Cardiovascular Diseases in the Japanese Population
Author / Creator:Ueno, Hikaru ; Uchida, Kotaro ; Kawashima, Honoka ; Hommo, Hiroto ; Sugawara, Takuya ; Minegishi, Shintaro ; Chen, Lin ; Sasaki-Nakashima, Rie ; Kino, Tabito ; Arakawa, Kentaro ; Sugiyama, Michiko ; Tamura, Koichi ; Hibi, Kiyoshi ; Ishigami, Tomoaki
Publisher:Switzerland: MDPI AG
Journal title:Journal of clinical medicine, 2025-07, Vol.14 (13), p.4722
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An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice
Author / Creator:Minegishi, Shintaro ; Ishigami, Tomoaki ; Kino, Tabito ; Chen, Lin ; Nakashima-Sasaki, Rie ; Araki, Naomi ; Yatsu, Keisuke ; Fujita, Megumi ; Umemura, Satoshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-06, Vol.6 (1), p.27137, Article 27137
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Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis

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Analysis of clinical factors associated with Kampo formula-induced pseudoaldosteronism based on self-reported information from the Japanese Adverse Drug Event Report database

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Japanese traditional Kampo medicine bofutsushosan improves body mass index in participants with obesity: A systematic review and meta-analysis

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Relationship between changes in blood pressure from summer to winter and estimated 24-hour salt excretion using spot urine: the Niigata Wellness Study

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Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI

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Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

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Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

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The effectiveness of a Kampo e-learning course incorporated into the medical education curriculum: a possible solution to instructor shortages and time constraints

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Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice

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Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products

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Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice

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Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling

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Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation

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Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension

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Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice

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The Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease

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Clinical impact of left ventricular systolic dysfunction in patients undergoing dialysis access surgery

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A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-t...

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AI-Induced Vascular Ages Are a Measurable Residual Risk for Cardiovascular Diseases in the Japanese Population

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An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

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