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ArticlesPeer ReviewedFull Text
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
Author / Creator:Willoughby, Catherine E. ; Jiang, Yanyan ; Thomas, Huw D. ; Willmore, Elaine ; Kyle, Suzanne ; Wittner, Anita ; Phillips, Nicole ; Zhao, Yan ; Tudhope, Susan J. ; Prendergast, Lisa ; Junge, Gesa ; Lourenco, Luiza Madia ; Finlay, M. Raymond V. ; Turner, Paul ; Munck, Joanne M. ; Griffin, Roger J. ; Rennison, Tommy ; Pickles, James ; Cano, Celine ; Newell, David R. ; Reeves, Helen L. ; Ryan, Anderson J. ; Wedge, Stephen R.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-01, Vol.130 (1), p.258-271
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Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma
Author / Creator:Noble, Richard A. ; Thomas, Huw ; Zhao, Yan ; Herendi, Lili ; Howarth, Rachel ; Dragoni, Ilaria ; Keun, Hector C. ; Vellano, Christopher P. ; Marszalek, Joseph R. ; Wedge, Stephen R.
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2022-09, Vol.127 (5), p.937-947
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Clinical development of new drug–radiotherapy combinations
Author / Creator:Sharma, Ricky A. ; Plummer, Ruth ; Stock, Julie K. ; Greenhalgh, Tessa A. ; Ataman, Ozlem ; Kelly, Stephen ; Clay, Robert ; Adams, Richard A. ; Baird, Richard D. ; Billingham, Lucinda ; Brown, Sarah R. ; Buckland, Sean ; Bulbeck, Helen ; Chalmers, Anthony J. ; Clack, Glen ; Cranston, Aaron N. ; Damstrup, Lars ; Ferraldeschi, Roberta ; Forster, Martin D. ; Golec, Julian ; Hagan, Russell M. ; Hall, Emma ; Hanauske, Axel-R. ; Harrington, Kevin J. ; Haswell, Tom ; Hawkins, Maria A. ; Illidge, Tim ; Jones, Hazel ; Kennedy, Andrew S. ; McDonald, Fiona ; Melcher, Thorsten ; O'Connor, James P. B. ; Pollard, John R. ; Saunders, Mark P. ; Sebag-Montefiore, David ; Smitt, Melanie ; Staffurth, John ; Stratford, Ian J. ; Wedge, Stephen R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2016-10, Vol.13 (10), p.627-642
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Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices
Author / Creator:Davies, Emma J. ; Dong, Meng ; Gutekunst, Matthias ; Närhi, Katja ; van Zoggel, Hanneke J. A. A. ; Blom, Sami ; Nagaraj, Ashwini ; Metsalu, Tauno ; Oswald, Eva ; Erkens-Schulze, Sigrun ; Delgado San Martin, Juan A. ; Turkki, Riku ; Wedge, Stephen R. ; af Hällström, Taija M. ; Schueler, Julia ; van Weerden, Wytske M. ; Verschuren, Emmy W. ; Barry, Simon T. ; van der Kuip, Heiko ; Hickman, John A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-12, Vol.5 (1), p.17187-17187, Article 17187
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Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib
Author / Creator:Novo, Sonia M. ; Wedge, Stephen R. ; Stark, Lesley A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-09, Vol.7 (1), p.12020-11, Article 12020
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Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies
Author / Creator:Kendrew, Jane ; Odedra, Rajesh ; Logié, Armelle ; Taylor, Paula J. ; Pearsall, Sharon ; Ogilvie, Donald J. ; Wedge, Stephen R. ; Jürgensmeier, Juliane M.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Cancer chemotherapy and pharmacology, 2013-04, Vol.71 (4), p.1021-1032
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Examining Changes in [18 F]FDG and [18 F]FLT Uptake in U87-MG Glioma Xenografts as Early Response Biomarkers to Treatment with the Dual mTOR1/2 Inhibitor AZD8055
Author / Creator:Keen, Heather G. ; Ricketts, Sally-Ann ; Maynard, Juliana ; Logie, Armelle ; Odedra, Rajesh ; Shannon, Aoife M. ; Wedge, Stephen R. ; Guichard, Sylvie M
Publisher:Boston: Springer US
Journal title:Molecular imaging and biology, 2014-06, Vol.16 (3), p.421-430
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ArticlesPeer ReviewedFull Text
Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model
Author / Creator:Brave, Sandra R. ; Eberlein, Cath ; Shibuya, Masabumi ; Wedge, Stephen R. ; Barry, Simon T.
Publisher:Dordrecht: Springer Netherlands
Journal title:Angiogenesis (London), 2010-12, Vol.13 (4), p.337-347
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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia
Author / Creator:ALFEREZ, DENIS G ; GOODLAD, ROBERT A ; ODEDRA, RAJESH ; SINI, PATRIZIA ; CRAFTER, CLAIRE ; RYAN, ANDERSON J ; WEDGE, STEPHEN R ; WRIGHT, NICHOLAS A ; ANDERSON, ELIZABETH ; WILKINSON, ROBERT W
Publisher:Athens: D.A. Spandidos
Journal title:International journal of oncology, 2012-10, Vol.41 (4), p.1475-1485
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ArticlesPeer ReviewedFull Text
Expression of stromal genes associated with the angiogenic response are not differentiated between human tumour xenografts with divergent vascular morphologies
Author / Creator:Farren, Matthew ; Weston, Susie ; Brown, Helen ; Broadbent, Nicola ; Powell, Steve ; Shaw, Robert ; Smith, Neil R. ; Inglis, Rachael ; Graham, Alex ; Ashton, Sue ; Wedge, Stephen R. ; Barry, Simon T.
Publisher:Dordrecht: Springer Netherlands
Journal title:Angiogenesis (London), 2012-12, Vol.15 (4), p.555-568
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An Evaluation of 2-deoxy-2-[18F]Fluoro-D-Glucose and 3′-deoxy-3′-[18F]-Fluorothymidine Uptake in Human Tumor Xenograft Models
Author / Creator:Keen, Heather ; Pichler, Bernd ; Kukuk, Damaris ; Duchamp, Olivier ; Raguin, Olivier ; Shannon, Aoife ; Whalley, Nichola ; Jacobs, Vivien ; Bales, Juliana ; Gingles, Neill ; Ricketts, Sally-Ann ; Wedge, Stephen R.
Publisher:New York: Springer-Verlag
Journal title:Molecular imaging and biology, 2012-06, Vol.14 (3), p.355-365
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ArticlesPeer ReviewedFull Text
Use of a Novel Arg-Gly-Asp Radioligand, 18F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy
Author / Creator:Morrison, Matthew S ; Ricketts, Sally-Ann ; Barnett, Jon ; Cuthbertson, Alan ; Tessier, Jean ; Wedge, Stephen R
Publisher:United States: Soc Nuclear Med
Journal title:The Journal of nuclear medicine (1978), 2009-01, Vol.50 (1), p.116-122
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ArticlesPeer ReviewedFull Text
Use of a Novel Arg-Gly-Asp Radioligand, 18 F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy
Author / Creator:Morrison, Matthew S. ; Ricketts, Sally-Ann ; Barnett, Jon ; Cuthbertson, Alan ; Tessier, Jean ; Wedge, Stephen R.
Journal title:Journal of Nuclear Medicine, 2009-01, Vol.50 (1), p.116-122
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ArticlesPeer ReviewedFull Text
Use of a Novel Arg-Gly-Asp Radioligand, ^sup 18^F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy
Author / Creator:Morrison, Matthew S ; Ricketts, Sally-Ann ; Barnett, Jon ; Cuthbertson, Alan ; Tessier, Jean ; Wedge, Stephen R
Publisher:New York: Society of Nuclear Medicine
Journal title:The Journal of nuclear medicine (1978), 2009-01, Vol.50 (1), p.116
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An Evaluation of 2-deoxy-2-[ super(18)F]Fluoro-D-Glucose and 3'-deoxy-3'-[ super(18)F]-Fluoroth ymidine Uptake in Human Tumor Xenograft Models
Author / Creator:Keen, Heather ; Pichler, Bernd ; Kukuk, Damaris ; Duchamp, Olivier ; Raguin, Olivier ; Shannon, Aoife ; Whalley, Nichola ; Jacobs, Vivien ; Bales, Juliana ; Gingles, Neill ; Ricketts, Sally-Ann ; Wedge, Stephen R
Journal title:Molecular imaging and biology, 2012-06, Vol.14 (3), p.355-365
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Effect of single and multiple administration of an O ? 6 -benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model
Author / Creator:Wedge, Stephen R. ; Porteous, Julia K. ; Newlands, E. S.
Journal title:Cancer chemotherapy and pharmacology, 1997-07, Vol.40 (3), p.266-272
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Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumour effects
Author / Creator:Towner, Laurence D ; Dahal, Lekh N ; Taylor, Martin C ; Cox, Kerry L ; Inzhelevskaya, Tatanya ; Mack, Matthias ; Wedge, Stephen R ; Richardson, Caroline ; Cragg, Mark S ; Beers, Stephen A
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2023-01
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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

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Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma

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Clinical development of new drug–radiotherapy combinations

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Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

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Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib

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Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies

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Examining Changes in [18 F]FDG and [18 F]FLT Uptake in U87-MG Glioma Xenografts as Early Response Biomarkers to Treatment with the Dual mTOR1/2 Inhibitor AZD8055

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Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model

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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia

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Expression of stromal genes associated with the angiogenic response are not differentiated between human tumour xenografts with divergent vascular morphologies

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An Evaluation of 2-deoxy-2-[18F]Fluoro-D-Glucose and 3′-deoxy-3′-[18F]-Fluorothymidine Uptake in Human Tumor Xenograft Models

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Use of a Novel Arg-Gly-Asp Radioligand, 18F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy

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Use of a Novel Arg-Gly-Asp Radioligand, 18 F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy

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Use of a Novel Arg-Gly-Asp Radioligand, ^sup 18^F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy

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An Evaluation of 2-deoxy-2-[ super(18)F]Fluoro-D-Glucose and 3'-deoxy-3'-[ super(18)F]-Fluoroth ymidine Uptake in Human Tumor Xenograft Models

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Effect of single and multiple administration of an O ? 6 -benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

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Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumour effects

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