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PRESENTED BY DUNCAN, OCT. 1935
1. Church of S. Ignatius, Richmond, Melbourne / Wardell & Vernon Architects [print] 
Drawer 4. Transferred from SPF/Melbourne - Churches - St. Ignatius, Richmond.

A. DUNCAN (RECEIVED BY THE LIBRARY IN 1967)
2. Photograph of Abel Tazman (ship) / Copyright photograph A. Duncan...Gravesend, Kent.
3. Photograph of Lotara (ship) / Copyright photograph A. Duncan...Gravesend, Kent.

PRESENTED BY VAUCLUSE HOUSE, JULY 1957 (Presented to Vaucluse House by W. Duncan Esq. Trustee of Vaucluse House)
4. Domain Lodge near St Mary's, in 1843 [copy photograph of drawing]. (Transferred from SPF/Sydney – Parks – Domain, 1843).
5. Elizabeth Bay House, Alexander Macleay’s residence, about 1850. (Transferred from SPF/Sydney – Residences – Elizabeth Bay House).

PRESENTED BY MRS A. DUNDAS, MARCH 1962
6. P. D. Hospital, Parramatta, N.S.W. (Transferred from SPF/Parramatta – Hospitals – District Hospital).

PRESENTED BY MRS A. D. DUREY[?], 2 JUNE 1938[?]
7. Mrs Scott Siddons, neice of the great JW[?] / Elite Photographic Studio. 838 Market St. San Francisco Cal. (Transferred from P1/Siddons, Mrs Scott).

PURCHASED FROM DYMOCK, 13 DECEMBER, 1910
8. Arthur Adams / Kerry & Co. (Transferred from P1/Adams, Arthur).
9. Arthur Baylden [Bayldon?] / Victorai Studio...Warwick. (Transferred from P1/Baylden, Arthur).
10. E. J. Brady / W. Stevenson. Fitzroy Street. Grafton C. R. (Transferred from P1/Brady, E. J., neagative available at FM1/2090).
11. Joseph Furphy / Peirce Photo. Shepparton. Victoria. (Transferred from P1/Furphy, Joesph).
12-13. James Hebblethwaite / A. N. Marshall Photo. Latrobe and Devonport. (Transferred from P1/Hebblethwaite, James).
14. Frank Morton, Jan. 1900 / Alba Studio...Hobart. (Transferred from P1/Morton, Frank)
15. Will H. Ogilvie, January 1901 / Kerry & Co. (Transferred from P1/Ogilvie, Will H.).

PRESENTED BY G. EARDLEY/G. H. EARDLEY IN 1937, 1956, 1958, & 1961 & ORIGINALS LENT FOR COPYING IN 1962
16. Aborigine Camp, Endeavour St, Sans Souci [copy photograph]. (Transferred from SPF/Australian Aborigines – N.S.W.).
Female in photograph is "Biddy Giles". One of the last speakers of Dharawal language group. Identified in Oct. 1998 by Shayne Williams, great-great grandson of Mrs Giles. Negative available at FM1/4210, microfilm is at FM3/475).
17. Aborigine Camp, Endeavour St, Sans Souci [copy photograph]. (Transferred from SPF/Australian Aborigines – N.S.W.).
Negative available at FM1/4211, microfilm is at FM3/475).
18. Hotel, Jellore St. Berrima / GHE 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. - Hotels, microfilm available at FM3/508).
19. Breen's hotel. Sydney Road. Berrima / GHE 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Hotels – Breen’s Hotel, microfilm available at FM3/508). 
20. The Coach and Horses Inn. Jellore St. Berrima / GHE 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Hotels – Coach & Horses Inn, microfilm available at FM3/508).
21. The "Surveyor General". Berrima / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Hotels – Surveyor General, microfilm available at FM3/508).
22. Taylor's Hotel. Powell's Store, Berrima / G. H. Eardley 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Hotels – Taylor’s Hotel, microfilm available at FM3/508).
23. The White Horse Inn, Market St., Berrima / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Hotels – White Horse Inn, microfilm available at FM3/508).
24. The former Masonic Hall, Berrima. Built 1867. Later to Presbyterian Church / GHE 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Public Buildings – Masonic Hall,  microfilm available at FM3/508).
25. The Police Station, Hume Highway, Berrima / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Public Buildings – Police Station, microfilm available at FM3/508).
26. Belle-vue House (Mr Matthews), Oxley St., Berrima / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Belle-Vue House, microfilm available at FM3/508).
27. "Carramar", Oxley St, Berrima (Mr Chapronecle[?] 1865 / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Carramar, microfilm available at FM3/508).
28. The Bakehouse and Stables, "Hampton Court", Market St, Berrima / GHE 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Hampton Court, microfilm available at FM3/508).
29. "Hampton Court" now "Ballynahinch", Market St. Berrima, Old School Room / G. H. Eardley 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Hampton Court, microfilm available at FM3/508).
30. Harper's Mansion. Wilkinson Street. Berrima. built by builder of "Surveyor General" Inn / G. H. Eardley 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Harper’s Mansion, microfilm available at FM3/508).
31. Small's House, Berrima / G. H. Eardley 1932 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Residences – Small’s House, microfilm available at FM3/508).
32. Cottage at Jellore St., Berrima / G.H.E. 7/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Streets – Jellore Street - Residences, microfilm available at FM3/508).
33. Mr Brown's Residence, Market St., Berrima (adjacent to Bridge) / G.H.Eardley 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Streets – Market Street – Residences – Mr Brown’s Residence, microfilm available at FM3/508).
34. Mrs Kerry's Home. Oldbury road, Berrima / GHE 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Streets – Oldbury Road – Residences – Mrs Kerry’s Home, microfilm available at FM3/508).
35. Cottage in Sydney Road, Berrima / G.H.E. 8/62 [copy photograph of drawing]. (Transferred from SPF/Berrima, N.S.W. – Streets – Sydney Road – Residences, microfilm available at FM3/508).
36. "Mary Ann". Built for a timber mill adjacent to Maryborough Qld (transferred from SPF/Locomotives).
37. Locomotive built by Mr T. Wearne for a tramway in N.S.W. on the 2ft gauge. This locomotive is reputed to have operated a small pleasure railway in the grounds of the Sir Joseph Banks Hotel at Botany. Photo from Mrs C. V. Chadwick, Cronulla [copy photograph] (transferred from SPF/Locomotives).
38. First locomotive to run into Bourke St. (transferred from SPF/Locomotives - N.S.W.).
39. "Sandy Ferguson". Built by H. Vale, Sydney, 1884. Maker's Number 30... / Photo by G. H Eardley (transferred from SPF/Locomotives - N.S.W.).
40. Second engine built in N.S.W. by Vale & Lacy 1867 (transferred from SPF/Locomotives - N.S.W.). 
41. No. 976 renumbered in 1924 to 5358. Built by Clyde Engineering Works, Granville N.S.W. 1913. Makers Number 113... (transferred from SPF/Locomotives - N.S.W.).
42-43. Govt. Wharf, Nambucca Hds, 1909 / H. Rickerby Photo [copy photographs of front and verso of postcard] (transferred from SPF/Nambucca Heads).
44-45. Nambucca Hds, 1909 / H. Rickerby Photo [copy photographs of front and verso of postcard] (transferred from SPF/Nambucca Heads).
46. [Albert Hotel] (transferred from SPF/Sydney - Hotels - Albert, n.d.).
47. [Copy photograph of print of Sans Souci Hotel] (transferred from SPF/Sydney – Hotels – Sans Souci Hotel, n.d., microfilm available at FM3/475).
48. 'Wickham', Mr Richardson, Rocky Pt Road, Arncliffe, possibly 1881 (transferred from SPF/Sydney – Residences – Wickham, c. 1881).
49. My Walker's Residence, Walker St, Arncliffe. Mr Walker was Minister of local Primitive Methodist Church in Arncliffe Street / GHE 2/55 [copy photograph of drawing] (transferred from SPF/Sydney – Suburbs - Arncliffe, microfilm available at FM3/475).
50. The house of Sun Lee, Arncliffe Road. Incorporates Primitive Methodist Church / G. H. Eardley 2/55 [copy photograph of drawing] (transferred from SPF/Sydney – Suburbs - Arncliffe, microfilm available at FM3/475).
51. Swimming Pool, Yaralla (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3953.
52. Yaralla (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3953.
53. Yaralla (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3964.
54, "Yaralla" Walker Estate (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3964.
55. Fountain, Yaralla (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3963.
56. Yaralla (transferred from SPF/Sydney – Suburbs – Concord – Residences - Yaralla). Negative available at FM1/3963.

PRESENTED BY J. W. EARNSHAW IN 1951 & 1957
57-58. Musoorie Cemetery, India. Grave of John Lang, early Australian writer (transferred from SPF/Lang, John).
59. Hunter's Hill House. Auchinairn. 1889. Home of Thomas Muir. From an album of photographs in the Mitchell Library, Glasgow (transferred from SPF/Muir, Thomas – Residence).
60. 25 (or 31) Euroka Street, North Sydney. Mrs Byer’s home, where Henry Lawson stayed. Mr Mutch standing at gate. Taken Sep. 1957 (transferred from SPF/Sydney – Suburbs – North Sydney - Residences). Notes verso of phorograph.

PRESENTED BY MRS M. EBELING[?] IN 1959
61. Wolloomooloo Bay and Sydney Heads from Domain [postcard] (transferred from SPF/Sydney – Harbour Is. – Woolloomooloo Bay).

PRESENTED BY J. W. EDDES, AUGUST 1939[?]
62. View of Sydney Harbour from North Sydney, showing the entire American Fleet and Auxilliaries, [1908] [photomechanical print] / Swain Photo.
Panoramic view in 3 sections. Inscribed in ink 'Drawer 3'. Transferred from Ships File/American Fleet Visit, 1908.
63. View from the Heights of Mosman, overlooking Cremorne Point, [1908] [photomechanical print] / Swain Photo.
Panoramic view in 3 sections. Inscribed in ink 'Drawer 3'. Transferred from Ships File/American Fleet Visit, 1908.
64. View of Sydney Harbour and the American Fleet, from Cremorne Heights, [1908] [photomechanical print] / Swain Photo.
Panoramic view in 3 sections. Inscribed in ink 'Drawer 3'. Transferred from Ships File/American Fleet Visit, 1908.
65. Sydney Harbour from the Heights of North Sydney, showing the Fleet, and City in the background, [1908] [photomechanical print] / Swain Photo.
Panoramic view in 3 sections. Inscribed in ink 'Drawer 3'. Transferred from Ships File/American Fleet Visit, 1908.
66. Panorama of the American Fleet in Sydney Harbour, [1908] [photomechanical print] / Kerry & Co. (transferred from SPF/Sydney – Harbour and Islands, 1908).

PRESENTED BY C. P. EDEN, SEPTEMBER 1952
Transferred from SPF/Range - Finding:
67. 30 ft. Base Duplex Rangefinder type F.M.9 on Naval Anti-Vibration Mounting type M.R.16 (made in 1940) / Barr & Stroud Limited, Glasgow, 1952 
68. 7850 Naval Rangefinder type F.A. No. 3. 4ft. 6in. base. The first Rangefinder sold to the Admiralty - 1893) / Barr & Stroud Limited, Glasgow, 1952.
69. No. 8250. The Barr and Stroud Range Finder / Barr & Stroud Limited, Glasgow, 1952.

PRESENTED[?] BY W. EDGECOMBE
Transferred from SPF - Commonwealth Celebrations:
70-73. [Decorative arches, ca. 1900] 
Negatives of 3 of the photographs available at FM1/3671, FM1/3668, and FM1/3669.
74. [Photograph of rotunda]
Negative available at FM1/3667.

PRESENTED BY ADRIAN EDMONDS, LANDS DEPT., SYDNEY, OCTOBER 1919
75. 15 inch German Gun near Proyart (on the Somme) destroyed by the Germans on evacuation. The view shows inside of the mounting and the trunnion. (Transferred from SPF/World War I – Artillery, 1914-19).

PRESENTED BY EDWARDS, NOVEMBER 1935
76. Photo of the Conference on Eastern Trade possibilities held in Parliament House...Sydney..., Feb. 1933. (Transferred from SPG/Conference on Eastern Trade Possibilities).

OFFERED BY WILLIAM S. ELLERDEN, DECEMBER 1975
77. Lot 100. The Bay of Islands, New Zealand (1835). Conrad Martens [clipping from auction catalogue]. ((Transferred from SPF/Bay of Islands, New Zealand, 1835).

PRESENTED BY MR[?] H. ELLIS, MARCH 1949
Transferred from SPF/Macquarie, Lachlan – Grave:
78-81. Macquarie's Tomb

PRESENTED BY EMANUEL, DEC. 1961
82-83. [Photomechanical prints of drawings of Capt. James Cook relics and page from journal]. (transferred from SPF/Cook, James Capt. – Relics).

PRESENTED BY MISS K. ENGLISH, MARCH 1952
84. Ruins, Lighthouse, Old Boydtown, Eden (transferred from SPF/Boydtown - Lighthouses, N.S.W.).
85. Boyds Tower, South Head / Nida (7) (transferred from SPF/Boydtown, N.S.W. - Lighthouses).
86. The Old Wool Store at historic Boydtown / Nida (2) (transferred from SPF/Boydtown, N.S.W. – Shops, Offices Etc. – Wool Store).
87. 101. Lady Denman naming the Federal City "Canberra" 12.3.13 / H&S Copyright (transferred from SPF/Canberra – History – Foundation Ceremony, 1913).
88. Twofold Bay, Eden (transferred from SPF/Eden, N.S.W.).
89. Twofold Bay, Eden / W. S. Vogt, Photo (transferred from SPF/Eden, N.S.W.).
90. Coastal scene, Eden Lighthouse (transferred from SPF/Eden, N.S.W.).
91. Gunning Park / H&S (transferred from SPF/Gunning, N.S.W. – Parks and Gardens – Gunning Park).
92. Halley's Comet & Venus 16 May 1910 - taken at Yass (transferred from SPF/Halley's Comet).
93. [Photograph of grave of Hamiton Hume] / Howard & Shearsby, Yass (transferred from SPF/Hume, Hamilton - Grave).
94. Lake George / Howard & Shearsby, Yass (transferred from SPF/Lake George, N.S.W.).
95. Narooma, 1923 transferred from SPF/Narooma, N.S.W., 1923).
96. Hylands Hotel, Narooma, "South Coast" N.S.W. (transferred from SPF/Narooma, N.S.W. – Hotels – Hylands Hotel).
97. Twofold Bay, Eden  (transferred from SPF/Twofold Bay, N.S.W.).
98. [Photograph of ship Vincennes on beach at Manly] (transferred from Ships File/Vincennes, ship).
99. WeeJasper Cave / Howard & Shearsby, Yass (transferred from SPF/Wee Jasper, N.S.W.).
100. Cooma Cottage. Residence of the late Hamilton Hume Australian Explorer (transferred from SPF/Yass, N.S.W.).
101. Rooney's Hotel (from Court House), July 1900 [in flood] / C. A. Howard (transferred from SPF/Yass, N.S.W.).
102. View from Bridge, July 1900 [in flood] / C. A. Howard (transferred from SPF/Yass, N.S.W.).
103. The Yass Store / R. Caspers, Goulburn (transferred from SPF/Yass, N.S.W.).
104. [View of Yass] (transferred from SPF/Yass, N.S.W.).
105. 1254. Yass township / Kerry Photo, Sydney (transferred from SPF/Yass, N.S.W.).
106. Backwater in Rossi St., July 1900 [in flood] / C. A. Howard (transferred from SPF/Yass, N.S.W.).
107. Rossi St., Yass (transferred from SPF/Yass, N.S.W.).
108. St Clement's Church, Yass / R. Caspers, Goulburn (transferred from SPF/Yass, N.S.W.).
109. Yass Pastoral and Agricultural Association [emblem?] (transferred from SPF/Yass, N.S.W.).
110. Commercial Bank & Post Office Yass / Howard & Shearsby, Yass (transferred from SPF/Yass, N.S.W.).
111. St Clement's C. of E., Yass, about 1860 / H&S (transferred from SPF/Yass, N.S.W.).
112. Old St Andrews Presbyterian Church, Yass (transferred from SPF/Yass, N.S.W.).
113. Yass Hospital (transferred from SPF/Yass, N.S.W. - Hospitals - Yass Hospital).
114. Court House, Yass (transferred from SPF/Yass, N.S.W. - Public Buildings - Court House).
115. Cooma St., Yass (transferred from SPF/Yass, N.S.W. - Streets - Cooma Street).
116. Yass Weir (transferred from SPF/Yass - Weir).
117. Hatton's Corner, Yass / A. J. Shearsby, Photo (transferred from SPF/Yass District).
118. Hatton's Corner, Yass (transferred from SPF/Yass District).
119. Hatton's Corner, Yass / Howards & Shearsby, Yass (transferred from SPF/Yass District).
120-121. Hatton's Corner / Howards & Shearsby, Yass (transferred from SPF/Yass District).

PRESENTED BY MOSES ESLAKE, 1946
122. [Photograph of Henry Lawson statue]. Inscribed 'this photo given by Bertha Lawson to Jack Moses'. 
Transferred from SPF/Sydney – Monuments – Lawson, Henry, n.d.. Negative available at FM1/3555.

PRESENTED BY EVANS, SEPT. 1940
123. The Residence of Mr C. Rasp, previous to his discovery of the Broken Hill Mine / Patterson & Co Photos Copyright (transferred from SPF/Broken Hill – Residences – Mr C. Rasp’s Dwelling).

PRESENTED BY MRS J.[?] E. EVANS, DEC. 1943
124. Signals Division, N. G. V. R. in Park, Rabaul, 1940 (transferred from SPG/New Guinea Volunteer Reserve, Signals Division, 1940).

LENT FOR COPYING BY PROF. J. EWAN, 1974
125. Corrobborree or dance of the natives of New South Wales, [1836] [copy photograph]
Copied from xerox of Fernybough print from the collection of titian Ramsay Peale in the American Museum of Natural history lent by Prof. Ewan, 1974. See print in volume of Fernybough portraits at A 617. Transferred from SPF/Australian Aborigines – Rites and ceremonies).
Photoprint, black and white

PRESENTED BY DEPT. OF EXTERNAL AFFAIRS, OCT. 1953
Transferred from SPF/Cook, James Capt. – Monuments – Pacific Islands – Norfolk Island
Captain Cook Memorial, Norfolk Island - Unveiling Ceremony held on Friday, 24th July, 1953
126. Memorial after unveiling.
127. Mrs Ida McComish, F.R.G.S., who unveiled the Memorial.
128-129. His Honour the Administrator and Mrs McComish delivering their addresses to school children and members of the public at the unveiling ceremony.
130. Mrs McComish unveiling the Memorial.
131. (from left): Mrs Norman, His Honour the Administrator (Brigadier H. B. Norman, D.S.O., M.C.) and Mrs McComish.



BOX 18: Mitchell Library, Small Pictures File, Donor Name collections: Duncan to External Affairs (Department of), ca. 1836-1962

Summary Background The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial showed that initial antihypertensive therapy with benazepril plus amlodipine was superior to benazepril plus hydrochlorothiazide in reducing cardiovascular morbidity and mortality. We assessed the effects of these drug combinations on progression of chronic kidney disease. Methods ACCOMPLISH was a double-blind, randomised trial undertaken in five countries (USA, Sweden, Norway, Denmark, and Finland). 11 506 patients with hypertension who were at high risk for cardiovascular events were randomly assigned via a central, telephone-based interactive voice response system in a 1:1 ratio to receive benazepril (20 mg) plus amlodipine (5 mg; n=5744) or benazepril (20 mg) plus hydrochlorothiazide (12·5 mg; n=5762), orally once daily. Drug doses were force-titrated for patients to attain recommended blood pressure goals. Progression of chronic kidney disease, a prespecified endpoint, was defined as doubling of serum creatinine concentration or end-stage renal disease (estimated glomerular filtration rate <15 mL/min/1·73 m2 or need for dialysis). Analysis was by intention to treat (ITT). This trial is registered with ClinicalTrials.gov , number NCT00170950. Findings The trial was terminated early (mean follow-up 2·9 years [SD 0·4]) because of superior efficacy of benazepril plus amlodipine compared with benazepril plus hydrochlorothiazide. At trial completion, vital status was not known for 143 (1%) patients who were lost to follow-up (benazepril plus amlodipine, n=70; benazepril plus hydrochlorothiazide, n=73). All randomised patients were included in the ITT analysis. There were 113 (2·0%) events of chronic kidney disease progression in the benazepril plus amlodipine group compared with 215 (3·7%) in the benazepril plus hydrochlorothiazide group (HR 0·52, 0·41–0·65, p<0·0001). The most frequent adverse event in patients with chronic kidney disease was peripheral oedema (benazepril plus amlodipine, 189 of 561, 33·7%; benazepril plus hydrochlorothiazide, 85 of 532, 16·0%). In patients with chronic kidney disease, angio-oedema was more frequent in the benazepril plus amlodipine group than in the benazepril plus hydrochlorothiazide group. In patients without chronic kidney disease, dizziness, hypokalaemia, and hypotension were more frequent in the benazepril plus hydrochlorothiazide group than in the benazepril plus amlodipine group. Interpretation Initial antihypertensive treatment with benazepril plus amlodipine should be considered in preference to benazepril plus hydrochlorothiazide since it slows progression of nephropathy to a greater extent. Funding Novartis.

The Lancet (British edition), 2010-04, Vol.375 (9721), p.1173-1181

Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial

Summary Background In previous clinical trials in high-risk hypertensive patients, paradoxically higher cardiovascular event rates have been reported in patients of normal weight compared with obese individuals. As a prespecified analysis of the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial, we aimed to investigate whether the type of hypertension treatment affects patients' cardiovascular outcomes according to their body size. Methods On the basis of body-mass index (BMI), we divided the full ACCOMPLISH cohort into obese (BMI ≥30, n=5709), overweight (≥25 to <30, n=4157), or normal weight (<25, n=1616) categories. The ACCOMPLISH cohort had already been randomised to treatment with single-pill combinations of either benazepril and hydrochlorothiazide or benazepril and amlodipine. We compared event rates (adjusted for age, sex, diabetes, previous cardiovascular events, stroke, or chronic kidney disease) for the primary endpoint of cardiovascular death or non-fatal myocardial infarction or stroke. The analysis was by intention to treat. This trial is registered with ClinicalTrials.gov , number NCT00170950. Findings In patients allocated benazepril and hydrochlorothiazide, the primary endpoint (per 1000 patient-years) was 30·7 in normal weight, 21·9 in overweight, and 18·2 in obese patients (overall p=0·0034). However, in those allocated benazepril and amlodipine, the primary endpoint did not differ between the three BMI groups (18·2, 16·9, and 16·5, respectively; overall p=0·9721). In obese individuals, primary event rates were similar with both benazepril and hydrochlorothiazide and benazepril and amlodipine, but rates were significantly lower with benazepril and amlodipine in overweight patients (hazard ratio 0·76, 95% CI 0·59–0·94; p=0·0369) and those of normal weight (0·57, 0·39–0·84; p=0·0037). Interpretation Hypertension in normal weight and obese patients might be mediated by different mechanisms. Thiazide-based treatment gives less cardiovascular protection in normal weight than obese patients, but amlodipine-based therapy is equally effective across BMI subgroups and thus offers superior cardiovascular protection in non-obese hypertension. Funding Novartis Pharmaceuticals.

The Lancet (British edition), 2013-02, Vol.381 (9866), p.537-545

Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial

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BOX 18: Mitchell Library, Small Pictures File, Donor Name collections: Duncan to External Affairs (Department of), ca. 1836-1962

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Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised cont...

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Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial

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