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Safety and Tolerability of Empagliflozin in Patients with Type 2 Diabetes
Author / Creator:Kohler, Sven, MD ; Salsali, Afshin, MD ; Hantel, Stefan, PhD ; Kaspers, Stefan, MD ; Woerle, Hans J., MD ; Kim, Gabriel, MD ; Broedl, Uli C., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2016-06, Vol.38 (6), p.1299-1313
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Pharmacodynamic Effects of Single and Multiple Doses of Empagliflozin in Patients With Type 2 Diabetes
Author / Creator:Heise, Tim, MD ; Jordan, Jens, MD ; Wanner, Christoph, MD ; Heer, Martina, PhD ; Macha, Sreeraj, PhD ; Mattheus, Michaela, Dipl Biomath ; Lund, Søren S., MD ; Woerle, Hans J., MD ; Broedl, Uli C., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2016-10, Vol.38 (10), p.2265-2276
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Different Mechanisms for Impaired Fasting Glucose and Impaired Postprandial Glucose Tolerance in Humans
Author / Creator:Meyer, Christian ; Pimenta, Walkyria ; Woerle, Hans J ; Haeften, Timon Van ; Szoke, Ervin ; Mitrakou, Asimina ; Gerich, John
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2006-08, Vol.29 (8), p.1909-1914
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Acute Pharmacodynamic Effects of Empagliflozin With and Without Diuretic Agents in Patients With Type 2 Diabetes Mellitus
Author / Creator:Heise, Tim, MD ; Jordan, Jens, MD ; Wanner, Christoph, MD ; Heer, Martina, PhD ; Macha, Sreeraj, PhD ; Mattheus, Michaela, Dipl Biomath ; Lund, Søren S., MD ; Woerle, Hans J., MD ; Broedl, Uli C., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2016-10, Vol.38 (10), p.2248-2264.e5
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A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetics of Empagliflozin and Linagliptin After Coadministration in Healthy Male Volunteers
Author / Creator:Friedrich, Christian, MD ; Metzmann, Katrin, PhD ; Rose, Peter, MD ; Mattheus, Michaela ; Pinnetti, Sabine, MD ; Woerle, Hans J., MD
Publisher:United States: EM Inc USA
Journal title:Clinical therapeutics, 2013, Vol.35 (1), p.A33-A42
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Assessing Pharmacokinetic Interactions Between the Sodium Glucose Cotransporter 2 Inhibitor Empagliflozin and Hydrochlorothiazide or Torasemide in Patients With Type 2 Diabetes Mellitus: A Randomized,...
Author / Creator:Heise, Tim, MD ; Mattheus, Michaela ; Woerle, Hans J., MD ; Broedl, Uli C., MD ; Macha, Sreeraj, PhD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2015-04, Vol.37 (4), p.793-803
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Pharmacokinetics of Empagliflozin and Pioglitazone After Coadministration in Healthy Volunteers
Author / Creator:Macha, Sreeraj, MD ; Mattheus, Michaela ; Pinnetti, Sabine, MD ; Broedl, Uli C., MD ; Woerle, Hans J., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2015-07, Vol.37 (7), p.1503-1516
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Effect of Gemfibrozil, Rifampicin, or Probenecid on the Pharmacokinetics of the SGLT2 Inhibitor Empagliflozin in Healthy Volunteers
Author / Creator:Macha, Sreeraj, PhD ; Koenen, Rüdiger, MD ; Sennewald, Regina, MD ; Schöne, Katja, Dipl-Math ; Hummel, Noemi, DrSc ; Riedmaier, Stephan, PhD ; Woerle, Hans J., MD ; Salsali, Afshin, MD ; Broedl, Uli C., MD
Publisher:Bridgewater, NJ: Elsevier Inc
Journal title:Clinical therapeutics, 2014-02, Vol.36 (2), p.280-290.e1
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Lack of Clinically Relevant Drug–Drug Interaction Between Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, and Verapamil, Ramipril, or Digoxin in Healthy Volunteers
Author / Creator:Macha, Sreeraj, PhD ; Sennewald, Regina, MD ; Rose, Peter, MD ; Schoene, Katja, Dipl-Math ; Pinnetti, Sabine, MD ; Woerle, Hans J., MD ; Broedl, Uli C., MD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2013-03, Vol.35 (3), p.226-235
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Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
Author / Creator:Wanner, Christoph ; Inzucchi, Silvio E ; Lachin, John M ; Fitchett, David ; von Eynatten, Maximilian ; Mattheus, Michaela ; Johansen, Odd Erik ; Woerle, Hans J ; Broedl, Uli C ; Zinman, Bernard
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-07, Vol.375 (4), p.323-334
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ArticlesPeer ReviewedFull Text
Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide
Author / Creator:Woerle, Hans J ; Albrecht, Max ; Linke, Rainer ; Zschau, Silvia ; Neumann, Christoph ; Nicolaus, Mathias ; Gerich, John E ; Göke, Burkhard ; Schirra, Joerg
Publisher:United States: American Diabetes Association
Journal title:Diabetes care, 2008-12, Vol.31 (12), p.2325-2331
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Empagliflozin as Add-on to Metformin Plus Sulfonylurea in Patients With Type 2 Diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
Author / Creator:HÄRING, Hans-Ulrich ; MERKER, Ludwig ; SEEWALDT-BECKER, Elke ; WEIMER, Marc ; MEINICKE, Thomas ; WOERLE, Hans J ; BROEDL, Uli C
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2013-11, Vol.36 (11), p.3396-3404
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ArticlesPeer ReviewedFull Text
Long-Term Safety and Efficacy of Empagliflozin, Sitagliptin, and Metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
Author / Creator:FERRANNINI, Ele ; BERK, Andreas ; HANTEL, Stefan ; PINNETTI, Sabine ; HACH, Thomas ; WOERLE, Hans J ; BROEDL, Uli C
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2013-12, Vol.36 (12), p.4015-4021
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Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Author / Creator:Zinman, Bernard ; Wanner, Christoph ; Lachin, John M ; Fitchett, David ; Bluhmki, Erich ; Hantel, Stefan ; Mattheus, Michaela ; Devins, Theresa ; Johansen, Odd Erik ; Woerle, Hans J ; Broedl, Uli C ; Inzucchi, Silvio E
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-11, Vol.373 (22), p.2117-2128
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The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes
Author / Creator:Cherney, David ; Lund, Søren S. ; Perkins, Bruce A. ; Groop, Per-Henrik ; Cooper, Mark E. ; Kaspers, Stefan ; Pfarr, Egon ; Woerle, Hans J. ; von Eynatten, Maximilian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2016-09, Vol.59 (9), p.1860-1870
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ArticlesPeer ReviewedFull Text
Mechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor Regimens
Author / Creator:WOERLE, Hans J ; MARIUZ, Peter R ; MEYER, Christian ; REICHMAN, Richard C ; POPA, Emilia M ; DOSTOU, Jean M ; WELLE, Stephen L ; GERICH, John E
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2003-04, Vol.52 (4), p.918-925
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Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naïve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled...
Author / Creator:Roden, Michael ; Merker, Ludwig ; Christiansen, Anita Vedel ; Roux, Flavien ; Salsali, Afshin ; Kim, Gabriel ; Stella, Peter ; Woerle, Hans J ; Broedl, Uli C
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2015-12, Vol.14 (1), p.154-154, Article 154
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Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration
Author / Creator:Škrtić, Marko ; Yang, Gary K. ; Perkins, Bruce A. ; Soleymanlou, Nima ; Lytvyn, Yuliya ; von Eynatten, Maximilian ; Woerle, Hans J. ; Johansen, Odd Erik ; Broedl, Uli C. ; Hach, Thomas ; Silverman, Melvin ; Cherney, David Z. I.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2014-12, Vol.57 (12), p.2599-2602
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of Empagliflozin in Patients with Type 2 Diabetes Mellitus
Author / Creator:Heise, Tim ; Seman, Leo ; Macha, Sreeraj ; Jones, Peter ; Marquart, Alexandra ; Pinnetti, Sabine ; Woerle, Hans J. ; Dugi, Klaus
Publisher:Heidelberg: Springer Healthcare
Journal title:Diabetes therapy, 2013-12, Vol.4 (2), p.331-345
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Effect of Aging on Glucose Homeostasis: Accelerated deterioration of β-cell function in individuals with impaired glucose tolerance
Author / Creator:Szoke, Ervin ; Shrayyef, Muhammad Z ; Messing, Susan ; Woerle, Hans J ; van Haeften, Timon W ; Meyer, Christian ; Mitrakou, Asimina ; Pimenta, Walkyria ; Gerich, John E
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2008-03, Vol.31 (3), p.539-543
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Safety and Tolerability of Empagliflozin in Patients with Type 2 Diabetes

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Pharmacodynamic Effects of Single and Multiple Doses of Empagliflozin in Patients With Type 2 Diabetes

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Different Mechanisms for Impaired Fasting Glucose and Impaired Postprandial Glucose Tolerance in Humans

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Acute Pharmacodynamic Effects of Empagliflozin With and Without Diuretic Agents in Patients With Type 2 Diabetes Mellitus

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A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetics of Empagliflozin and Linagliptin After Coadministration in Healthy Male Volunteers

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Assessing Pharmacokinetic Interactions Between the Sodium Glucose Cotransporter 2 Inhibitor Empagliflozin and Hydrochlorothiazide or Torasemide in Patients With Type 2 Diabetes Mellitus: A Randomized,...

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Pharmacokinetics of Empagliflozin and Pioglitazone After Coadministration in Healthy Volunteers

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Effect of Gemfibrozil, Rifampicin, or Probenecid on the Pharmacokinetics of the SGLT2 Inhibitor Empagliflozin in Healthy Volunteers

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Lack of Clinically Relevant Drug–Drug Interaction Between Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, and Verapamil, Ramipril, or Digoxin in Healthy Volunteers

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Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

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Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide

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Empagliflozin as Add-on to Metformin Plus Sulfonylurea in Patients With Type 2 Diabetes: A 24-week, randomized, double-blind, placebo-controlled trial

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Long-Term Safety and Efficacy of Empagliflozin, Sitagliptin, and Metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes

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Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

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The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes

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Mechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor Regimens

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Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naïve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled...

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Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of Empagliflozin in Patients with Type 2 Diabetes Mellitus

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Effect of Aging on Glucose Homeostasis: Accelerated deterioration of β-cell function in individuals with impaired glucose tolerance

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