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Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
Author / Creator:Ferrannini, Ele ; Muscelli, Elza ; Frascerra, Silvia ; Baldi, Simona ; Mari, Andrea ; Heise, Tim ; Broedl, Uli C. ; Woerle, Hans-Juergen
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2014-02, Vol.124 (2), p.499-508
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Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial
Author / Creator:Barnett, Anthony H, Prof ; Huisman, Holger, MSc ; Jones, Russell, MSc ; von Eynatten, Maximilian, MD ; Patel, Sanjay, MB ChB ; Woerle, Hans-Juergen, MD
Publisher:Kidlington: Elsevier Ltd
Journal title:The Lancet (British edition), 2013-10, Vol.382 (9902), p.1413-1423
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Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
Author / Creator:Johansen, Odd ; Neubacher, Dietmar ; von Eynatten, Maximilian ; Patel, Sanjay ; Woerle, Hans-Juergen
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2012-01, Vol.11 (1), p.3-3
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Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)
Author / Creator:Zinman, Bernard ; Inzucchi, Silvio E ; Lachin, John M ; Wanner, Christoph ; Ferrari, Roberto ; Fitchett, David ; Bluhmki, Erich ; Hantel, Stefan ; Kempthorne-Rawson, Joan ; Newman, Jennifer ; Johansen, Odd ; Woerle, Hans-Juergen ; Broedl, Uli C
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2014-06, Vol.13 (1), p.102-102
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Empagliflozin as Add-on Therapy to Pioglitazone With or Without Metformin in Patients With Type 2 Diabetes Mellitus
Author / Creator:Kovacs, Christopher S., MD ; Seshiah, Veeraswamy, MD, FRCP ; Merker, Ludwig, MD ; Christiansen, Anita Vedel, MSc, Pharm ; Roux, Flavien, MSc ; Salsali, Afshin, MD ; Kim, Gabriel, MD ; Stella, Peter, MD ; Woerle, Hans-Juergen, MD ; Broedl, Uli C., MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2015-08, Vol.37 (8), p.1773-1788.e1
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Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinica...
Author / Creator:Rosenstock, Julio ; Perkovic, Vlado ; Alexander, John H. ; Cooper, Mark E. ; Marx, Nikolaus ; Pencina, Michael J. ; Toto, Robert D. ; Wanner, Christoph ; Zinman, Bernard ; Baanstra, David ; Pfarr, Egon ; Mattheus, Michaela ; Broedl, Uli C. ; Woerle, Hans-Juergen ; George, Jyothis T. ; von Eynatten, Maximilian ; McGuire, Darren K.
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2018-03, Vol.17 (1), p.39-39, Article 39
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Diurnal Glycemic Patterns during an 8-Week Open-Label Proof-of-Concept Trial of Empagliflozin in Type 1 Diabetes
Author / Creator:Perkins, Bruce A. ; Cherney, David Z. I. ; Soleymanlou, Nima ; Lee, Justin A. ; Partridge, Helen ; Tschirhart, Holly ; Zinman, Bernard ; Mazze, Roger ; Fagan, Nora ; Kaspers, Stefan ; Woerle, Hans-Juergen ; Broedl, Uli C. ; Johansen, Odd Erik
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-11, Vol.10 (11), p.e0141085-e0141085
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Efficacy and safety of linagliptin monotherapy in Asian patients with inadequately controlled type 2 diabetes mellitus: A multinational, 24-week, randomized, clinical trial
Author / Creator:Chen, Yuhong ; Ning, Guang ; Wang, Changjiang ; Gong, Yan ; Patel, Sanjay ; Zhang, Candice ; Izumoto, Toshiyasu ; Woerle, Hans-Juergen ; Wang, Weiqing
Publisher:Japan: Blackwell Publishing Ltd
Journal title:Journal of diabetes investigation, 2015-11, Vol.6 (6), p.692-698
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Efficacy and Tolerability of Linagliptin Added to a Sulfonylurea Regimen in Patients With Inadequately Controlled Type 2 Diabetes Mellitus: An 18-Week, Multicenter, Randomized, Double-Blind, Placebo-C...
Author / Creator:Lewin, Andrew J., MD ; Arvay, Lisa, MBA ; Liu, Dacheng, PhD ; Patel, Sanjay, MB, ChB ; von Eynatten, Maximilian, MD ; Woerle, Hans-Juergen, MD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2012-09, Vol.34 (9), p.1909-1919.e15
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Efficacy and Safety of Linagliptin in Subjects With Long-standing Type 2 Diabetes Mellitus (>10 Years): Evidence From Pooled Data of Randomized, Double-blind, Placebo-controlled, Phase III Trials
Author / Creator:Lajara, Rosemarie, MD ; Aguilar, Richard, MD ; Hehnke, Uwe, Dipl-Stat ; Woerle, Hans-Juergen, MD ; von Eynatten, Maximilian, MD
Publisher:Bridgewater, NJ: Elsevier Inc
Journal title:Clinical therapeutics, 2014-11, Vol.36 (11), p.1595-1605
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A Randomized, Open-Label, Crossover Study Evaluating the Effect of Food on the Relative Bioavailability of Linagliptin in Healthy Subjects
Author / Creator:Graefe-Mody, Ulrike, PhD ; Giessmann, Thomas, MD ; Ring, Arne, PhD ; Iovino, Mario, MD ; Woerle, Hans-Juergen, MD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2011-08, Vol.33 (8), p.1096-1103
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Linagliptin, a dipeptidyl peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: A phase I, randomized, double-blind, placebo-controlled trial of single and multiple escal...
Author / Creator:Sarashina, Akiko, MSc ; Sesoko, Shogo, MD ; Nakashima, Mitsuyoshi, MD ; Hayashi, Naoyuki, MSc ; Taniguchi, Atsushi, MSc ; Horie, Yoshiharu, PhD ; Graefe-Mody, Eva U., PhD ; Woerle, Hans-Juergen, MD ; Dugi, Klaus A., MD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2010-06, Vol.32 (6), p.1188-1204
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Linagliptin Lowers Albuminuria on Top of Recommended Standard Treatment in Patients With Type 2 Diabetes and Renal Dysfunction
Author / Creator:Groop, Per-Henrik ; Cooper, Mark E. ; Perkovic, Vlado ; Emser, Angela ; Woerle, Hans-Juergen ; von Eynatten, Maximilian
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2013-11, Vol.36 (11), p.3460-3468
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ArticlesPeer ReviewedFull Text
Pharmacokinetic, Pharmacodynamic, and Tolerability Profiles of the Dipeptidyl Peptidase-4 Inhibitor Linagliptin: A 4-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Study in J...
Author / Creator:Horie, Yoshiharu, PhD ; Kanada, Shigeto, MD ; Watada, Hirotaka, MD ; Sarashina, Akiko, MSc ; Taniguchi, Atsushi, MSc ; Hayashi, Naoyuki, MSc ; Graefe-Mody, Eva U., PhD ; Woerle, Hans-Juergen, MD ; Dugi, Klaus A., MD
Publisher:Bridgewater, NJ: Elsevier
Journal title:Clinical therapeutics, 2011-07, Vol.33 (7), p.973-989
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Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study
Author / Creator:McGill, Janet B ; Sloan, Lance ; Newman, Jennifer ; Patel, Sanjay ; Sauce, Christophe ; von Eynatten, Maximilian ; Woerle, Hans-Juergen
Publisher:United States: American Diabetes Association
Journal title:Diabetes care, 2013-02, Vol.36 (2), p.237-244
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Linagliptin Increases Incretin Levels, Lowers Glucagon, and Improves Glycemic Control in Type 2 Diabetes Mellitus
Author / Creator:Rauch, Thomas ; Graefe-Mody, Ulrike ; Deacon, Carolyn F. ; Ring, Arne ; Holst, Jens J. ; Woerle, Hans-Juergen ; Dugi, Klaus A. ; Heise, Tim
Publisher:Heidelberg: Springer Healthcare Communications
Journal title:Diabetes therapy, 2012-12, Vol.3 (1), p.10-10, Article 10
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Effects of Adding Linagliptin to Basal Insulin Regimen for Inadequately Controlled Type 2 Diabetes: A ≥52-week randomized, double-blind study
Author / Creator:YKI-JÄRVINEN, Hannele ; ROSENSTOCK, Julio ; DURAN-GARCIA, Santiago ; PINNETTI, Sabine ; BHATTACHARYA, Sudipta ; THIEMANN, Sandra ; PATEL, Sanjay ; WOERLE, Hans-Juergen
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2013-12, Vol.36 (12), p.3875-3881
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The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
Author / Creator:Cherney, David ZI ; Perkins, Bruce A ; Soleymanlou, Nima ; Har, Ronnie ; Fagan, Nora ; Johansen, Odd ; Woerle, Hans-Juergen ; von Eynatten, Maximilian ; Broedl, Uli C
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2014-01, Vol.13 (1), p.28-28
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2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial
Author / Creator:Gallwitz, Baptist, Prof ; Rosenstock, Julio, MD ; Rauch, Thomas, MD PhD ; Bhattacharya, Sudipta, MSJ ; Patel, Sanjay, MB ChB ; von Eynatten, Maximilian, MD ; Dugi, Klaus A, MD ; Woerle, Hans-Juergen, MD
Publisher:Kidlington: Elsevier Ltd
Journal title:The Lancet (British edition), 2012-08, Vol.380 (9840), p.475-483
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Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events
Author / Creator:Rosenstock, Julio ; Marx, Nikolaus ; Neubacher, Dietmar ; Seck, Thomas ; Patel, Sanjay ; Woerle, Hans-Juergen ; Johansen, Odd Erik
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2015-05, Vol.14 (1), p.57, Article 57
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Showing 1 to 20 of 41 results

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Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients

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Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial

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Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme

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Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)

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Empagliflozin as Add-on Therapy to Pioglitazone With or Without Metformin in Patients With Type 2 Diabetes Mellitus

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Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinica...

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Diurnal Glycemic Patterns during an 8-Week Open-Label Proof-of-Concept Trial of Empagliflozin in Type 1 Diabetes

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Efficacy and safety of linagliptin monotherapy in Asian patients with inadequately controlled type 2 diabetes mellitus: A multinational, 24-week, randomized, clinical trial

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Efficacy and Tolerability of Linagliptin Added to a Sulfonylurea Regimen in Patients With Inadequately Controlled Type 2 Diabetes Mellitus: An 18-Week, Multicenter, Randomized, Double-Blind, Placebo-C...

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Efficacy and Safety of Linagliptin in Subjects With Long-standing Type 2 Diabetes Mellitus (>10 Years): Evidence From Pooled Data of Randomized, Double-blind, Placebo-controlled, Phase III Trials

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A Randomized, Open-Label, Crossover Study Evaluating the Effect of Food on the Relative Bioavailability of Linagliptin in Healthy Subjects

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Linagliptin, a dipeptidyl peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: A phase I, randomized, double-blind, placebo-controlled trial of single and multiple escal...

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Linagliptin Lowers Albuminuria on Top of Recommended Standard Treatment in Patients With Type 2 Diabetes and Renal Dysfunction

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Pharmacokinetic, Pharmacodynamic, and Tolerability Profiles of the Dipeptidyl Peptidase-4 Inhibitor Linagliptin: A 4-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Study in J...

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Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study

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Linagliptin Increases Incretin Levels, Lowers Glucagon, and Improves Glycemic Control in Type 2 Diabetes Mellitus

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Effects of Adding Linagliptin to Basal Insulin Regimen for Inadequately Controlled Type 2 Diabetes: A ≥52-week randomized, double-blind study

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The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus

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2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial

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Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events

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