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ArticlesPeer ReviewedFull Text
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Author / Creator:Wilding, John P.H ; Batterham, Rachel L ; Calanna, Salvatore ; Davies, Melanie ; Van Gaal, Luc F ; Lingvay, Ildiko ; McGowan, Barbara M ; Rosenstock, Julio ; Tran, Marie T.D ; Wadden, Thomas A ; Wharton, Sean ; Yokote, Koutaro ; Zeuthen, Niels ; Kushner, Robert F
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2021-03, Vol.384 (11), p.989-1002
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ArticlesPeer ReviewedFull Text
The obesity-related pathology and Th17 cells
Author / Creator:Endo, Yusuke ; Yokote, Koutaro ; Nakayama, Toshinori
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2017-04, Vol.74 (7), p.1231-1245
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ArticlesPeer ReviewedFull Text
Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes
Author / Creator:Maezawa, Yoshiro ; Takemoto, Minoru ; Yokote, Koutaro
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Journal of diabetes investigation, 2015-01, Vol.6 (1), p.3-15
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Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
Author / Creator:Angela, Mulki ; Endo, Yusuke ; Asou, Hikari K. ; Yamamoto, Takeshi ; Tumes, Damon J. ; Tokuyama, Hirotake ; Yokote, Koutaro ; Nakayama, Toshinori
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-11, Vol.7 (1), p.13683-13683, Article 13683
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ArticlesPeer ReviewedFull Text
Updates on dyslipidemia in patients with diabetes
Author / Creator:Ide, Shintaro ; Maezawa, Yoshiro ; Yokote, Koutaro
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Journal of diabetes investigation, 2023-09, Vol.14 (9), p.1041-1044
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ArticlesPeer ReviewedFull Text
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Author / Creator:Fang, Evandro F. ; Hou, Yujun ; Lautrup, Sofie ; Jensen, Martin Borch ; Yang, Beimeng ; SenGupta, Tanima ; Caponio, Domenica ; Khezri, Rojyar ; Demarest, Tyler G. ; Aman, Yahyah ; Figueroa, David ; Morevati, Marya ; Lee, Ho-Joon ; Kato, Hisaya ; Kassahun, Henok ; Lee, Jong-Hyuk ; Filippelli, Deborah ; Okur, Mustafa Nazir ; Mangerich, Aswin ; Croteau, Deborah L. ; Maezawa, Yoshiro ; Lyssiotis, Costas A. ; Tao, Jun ; Yokote, Koutaro ; Rusten, Tor Erik ; Mattson, Mark P. ; Jasper, Heinrich ; Nilsen, Hilde ; Bohr, Vilhelm A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-11, Vol.10 (1), p.5284-18, Article 5284
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ArticlesPeer ReviewedFull Text
Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice
Author / Creator:Shibuya, Shuichi ; Ozawa, Yusuke ; Watanabe, Kenji ; Izuo, Naotaka ; Toda, Toshihiko ; Yokote, Koutaro ; Shimizu, Takahiko
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-10, Vol.9 (10), p.e109288
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Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020
Author / Creator:Kato, Hisaya ; Koshizaka, Masaya ; Kaneko, Hiyori ; Maezawa, Yoshiro ; Yokote, Koutaro
Publisher:England: BioMed Central Ltd
Journal title:Orphanet journal of rare diseases, 2022-06, Vol.17 (1), p.226-226, Article 226
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Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?
Author / Creator:Ono, Hiraku ; Yokote, Koutaro
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Journal of diabetes investigation, 2021-11, Vol.12 (11), p.1942-1943
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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
Author / Creator:Suzuki, Sawako ; Tanaka, Tomoaki ; Poyurovsky, Masha V. ; Nagano, Hidekazu ; Mayama, Takafumi ; Ohkubo, Shuichi ; Lokshin, Maria ; Hosokawa, Hiroyuki ; Nakayama, Toshinori ; Suzuki, Yutaka ; Sugano, Sumio ; Sato, Eiichi ; Nagao, Toshitaka ; Yokote, Koutaro ; Tatsuno, Ichiro ; Prives, Carol
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (16), p.7461-7466
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Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration
Author / Creator:Koike, Masato ; Nojiri, Hidetoshi ; Ozawa, Yusuke ; Watanabe, Kenji ; Muramatsu, Yuta ; Kaneko, Haruka ; Morikawa, Daichi ; Kobayashi, Keiji ; Saita, Yoshitomo ; Sasho, Takahisa ; Shirasawa, Takuji ; Yokote, Koutaro ; Kaneko, Kazuo ; Shimizu, Takahiko
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-06, Vol.5 (1), p.11722-11722, Article 11722
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Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate
Author / Creator:Sakamoto, Kenichi ; Yokote, Koutaro
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Journal of diabetes investigation, 2020-07, Vol.11 (4), p.783-785
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CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet
Author / Creator:Kurita, Kenichi ; Ishikawa, Ko ; Takeda, Kenji ; Fujimoto, Masanori ; Ono, Hiraku ; Kumagai, Jin ; Inoue, Hiromi ; Yokoh, Hidetaka ; Yokote, Koutaro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-04, Vol.9 (1), p.6165, Article 6165
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Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis
Author / Creator:Fujimoto, Masanori ; Yokoyama, Masataka ; Kiuchi, Masahiro ; Hosokawa, Hiroyuki ; Nakayama, Akitoshi ; Hashimoto, Naoko ; Sakuma, Ikki ; Nagano, Hidekazu ; Yamagata, Kazuyuki ; Kudo, Fujimi ; Manabe, Ichiro ; Lee, Eunyoung ; Hatano, Ryo ; Onodera, Atsushi ; Hirahara, Kiyoshi ; Yokote, Koutaro ; Miki, Takashi ; Nakayama, Toshinori ; Tanaka, Tomoaki
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5408-5408, Article 5408
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Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double-blind placebo-contro...
Author / Creator:Yokote, Koutaro ; Yamashita, Shizuya ; Arai, Hidenori ; Araki, Eiichi ; Matsushita, Mitsunori ; Nojima, Toshiaki ; Suganami, Hideki ; Ishibashi, Shun
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2021-05, Vol.20 (1), p.96-96, Article 96
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Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia
Author / Creator:Deguchi-Horiuchi, Hanna ; Suzuki, Sawako ; Lee, Eun Young ; Miki, Takashi ; Yamanaka, Noriko ; Manabe, Ichiro ; Tanaka, Tomoaki ; Yokote, Koutaro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-05, Vol.13 (1), p.7291-7291, Article 7291
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Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
Author / Creator:Paul, Sudip Kumar ; Oshima, Motohiko ; Patil, Ashwini ; Sone, Masamitsu ; Kato, Hisaya ; Maezawa, Yoshiro ; Kaneko, Hiyori ; Fukuyo, Masaki ; Rahmutulla, Bahityar ; Ouchi, Yasuo ; Tsujimura, Kyoko ; Nakanishi, Mahito ; Kaneda, Atsushi ; Iwama, Atsushi ; Yokote, Koutaro ; Eto, Koji ; Takayama, Naoya
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-06, Vol.15 (1), p.4772-17, Article 4772
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Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
Author / Creator:Shoda, Jumpei ; Tanaka, Shigeru ; Etori, Keishi ; Hattori, Koto ; Kasuya, Tadamichi ; Ikeda, Kei ; Maezawa, Yuko ; Suto, Akira ; Suzuki, Kotaro ; Nakamura, Junichi ; Maezawa, Yoshiro ; Takemoto, Minoru ; Betsholtz, Christer ; Yokote, Koutaro ; Ohtori, Seiji ; Nakajima, Hiroshi
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2022-06, Vol.24 (1), p.134-134, Article 134
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Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis
Author / Creator:Kobayashi, Keiji ; Nojiri, Hidetoshi ; Saita, Yoshitomo ; Morikawa, Daichi ; Ozawa, Yusuke ; Watanabe, Kenji ; Koike, Masato ; Asou, Yoshinori ; Shirasawa, Takuji ; Yokote, Koutaro ; Kaneko, Kazuo ; Shimizu, Takahiko
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-03, Vol.5 (1), p.9148-9148, Article 9148
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Association between glycemic control and cardiovascular events in older Japanese adults with diabetes mellitus: An analysis of the Japanese medical administrative database
Author / Creator:Yokote, Koutaro ; Suzuki, Ryo ; Gouda, Maki ; Iijima, Hiroaki ; Yamazaki, Akiko ; Inagaki, Masaya
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Journal of diabetes investigation, 2021-11, Vol.12 (11), p.2036-2045
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Once-Weekly Semaglutide in Adults with Overweight or Obesity

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The obesity-related pathology and Th17 cells

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Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

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Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

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Updates on dyslipidemia in patients with diabetes

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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

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Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice

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Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020

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Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?

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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

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Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

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Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate

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CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet

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Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

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Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double-blind placebo-contro...

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Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia

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Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model

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Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

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Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

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Association between glycemic control and cardiovascular events in older Japanese adults with diabetes mellitus: An analysis of the Japanese medical administrative database

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