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ArticlesPeer ReviewedFull Text
Linzagolix: First Approval: Linzagolix: First Approval
Author / Creator:Keam, Susan J.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2022-08, Vol.82 (12), p.1317-1325
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ArticlesPeer ReviewedFull Text
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors
Author / Creator:Tezuka, Motohiro ; Tamai, Yasuaki ; Kuramochi, Yu ; Kobayashi, Kaoru ; Fushimi, Nobuhiko ; Kiguchi, Sumiyoshi
Publisher:Australia: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2022-10, Vol.49 (10), p.1082-1093
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ArticlesPeer ReviewedFull Text
Suppression of hypothalamic–pituitary–gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models
Author / Creator:Tezuka, Motohiro ; Yonekubo‐Awaka, Saori ; Tamai, Yasuaki ; Tsuchioka, Kumi ; Kobayashi, Kaoru ; Kuramochi, Yu ; Tatemichi, Satoshi ; Nagasawa, Tatsuya ; Kiguchi, Sumiyoshi
Publisher:Richmond: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2023-11, Vol.50 (11), p.914-923
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ArticlesPeer ReviewedFull Text
Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials
Author / Creator:Donnez, Jacques ; Taylor, Hugh S ; Stewart, Elizabeth A ; Bradley, Linda ; Marsh, Erica ; Archer, David ; Al-Hendy, Ayman ; Petraglia, Felice ; Watts, Nelson ; Gotteland, Jean-Pierre ; Bestel, Elke ; Terrill, Paul ; Loumaye, Ernest ; Humberstone, Andrew ; Garner, Elizabeth
Publisher:London: Elsevier Limited
Journal title:The Lancet (British edition), 2022-09, Vol.400 (10356), p.896-907
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ArticlesPeer ReviewedFull Text
Suppressive effects of linzagolix, a novel non‐peptide antagonist of gonadotropin‐releasing hormone receptors, in experimental endometriosis model rats
Author / Creator:Tezuka, Motohiro ; Tsuchioka, Kumi ; Kobayashi, Kaoru ; Kuramochi, Yu ; Kiguchi, Sumiyoshi
Publisher:Australia: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2023-07, Vol.50 (7), p.610-617
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ArticlesPeer ReviewedFull Text
Uterine Adenomyosis Treated by Linzagolix, an Oral Gonadotropin-Releasing Hormone Receptor Antagonist: A Pilot Study with a New ’Hit Hard First and then Maintain’ Regimen of Administration
Author / Creator:Donnez, Jacques ; Donnez, Olivier ; Tourniaire, Jean ; Brethous, Michel ; Bestel, Elke ; Garner, Elizabeth ; Charpentier, Sébastien ; Humberstone, Andrew ; Loumaye, Ernest
Publisher:Switzerland: MDPI AG
Journal title:Journal of clinical medicine, 2021-12, Vol.10 (24), p.5794
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ArticlesPeer ReviewedFull Text
Linzagolix: an oral gonadotropin-releasing hormone receptor antagonist treatment for uterine fibroid-associated heavy menstrual bleeding
Author / Creator:de Lange, Maria E ; Huirne, Judith A F
Publisher:London: Elsevier Limited
Journal title:The Lancet (British edition), 2022-09, Vol.400 (10356), p.866-867
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ArticlesPeer ReviewedFull Text
Profile of Linzagolix in the Management of Endometriosis, Including Design, Development and Potential Place in Therapy: A Narrative Review
Author / Creator:Donnez, Jacques ; Cacciottola, Luciana ; Squifflet, Jean-Luc ; Dolmans, Marie-Madeleine
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2023-01, Vol.17, p.369-380
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ArticlesPeer ReviewedFull Text
Linzagolix in moderate to severe symptoms of uterine fibroids: a profile of its use
Author / Creator:Fung, Simon ; Blair, Hannah A.
Publisher:Cham: Springer International Publishing
Journal title:Drugs & therapy perspectives : for rational drug selection and use, 2023-09, Vol.39 (9), p.309-316
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ArticlesPeer ReviewedFull Text
Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials
Author / Creator:Donnez, Jacques ; Petraglia, Felice ; Taylor, Hugh ; Becker, Christian ; Becker, Sven ; Carmona Herrera, Francisco ; Paszkowski, Maciej ; Bestel, Elke ; Hori, Satoshi ; Dolmans, Marie-Madeleine
Journal title:Human reproduction open, 2025-05
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ArticlesPeer ReviewedFull Text
Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents
Author / Creator:Othman, Essam ; Al-Hendy, Ayman ; Mostafa, Radwa ; Lambalk, Cornelis ; Mijatovic, Velja
Publisher:New Zealand: Dove Medical Press Limited
Journal title:International journal of women's health, 2024-01, Vol.16, p.309-321
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StandardsFull Text
Linzagolix for treating moderate to severe symptoms of uterine fibroids
Publisher:London: National Institute for Health and Care Excellence (NICE)
Journal title:NICE Guidance, 2024
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Newsletter articlesFull Text
Obseva Announced FDA Acceptance of NDA for Linzagolix
Author / Creator:Gross, Charles
Publisher:Southfield: Accretive Capital LLC d/b/a Benzinga
Journal title:Benzinga Newswires, 2021
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Newsletter articlesFull Text
ObsEva Presents Linzagolix Data From Uterine Fibroid Trials
Author / Creator:Singh, Vandana
Publisher:Southfield: Accretive Capital LLC d/b/a Benzinga
Journal title:Benzinga Newswires, 2021
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Newsletter articlesFull Text
ObsEva Files US Application For Linzagolix For Uterine Fibroids
Author / Creator:Singh, Vandana
Publisher:Southfield: Accretive Capital LLC d/b/a Benzinga
Journal title:Benzinga Newswires, 2021
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Newsletter articlesFull Text
ObsEva Announces Additional Efficacy Results For Linzagolix 200 mg With Add-Back Therapy And Linzagolix 75 mg Without ABT In Phase 3 EDELWEISS 3 Trial In Patients With Moderate-To-Severe Endometriosis...
Author / Creator:Haddad, Bill
Publisher:Southfield: Accretive Capital LLC d/b/a Benzinga
Journal title:Benzinga Newswires, 2022
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Newsletter articlesFull Text
ObsEva Announced Topline Results for Linzagolix 200 mg with Add-Back Therapy in the Phase 3 EDELWEISS 3 Trial in Patients with Moderate-to-Severe Endometriosis-Associated Pain; Said Once Daily linzago...
Author / Creator:Gross, Charles
Publisher:Southfield: Accretive Capital LLC d/b/a Benzinga
Journal title:Benzinga Newswires, 2022
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ArticlesPeer ReviewedFull Text
Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists
Author / Creator:Donnez, Jacques ; Stratopoulou, Christina Anna ; Dolmans, Marie-Madeleine
Publisher:Basel: MDPI AG
Journal title:International journal of environmental research and public health, 2021-09, Vol.18 (19), p.9941
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ArticlesPeer ReviewedFull Text
GnRH Antagonists with or without Add-Back Therapy: A New Alternative in the Management of Endometriosis?
Author / Creator:Donnez, Jacques ; Dolmans, Marie-Madeleine
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-10, Vol.22 (21), p.11342
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ArticlesPeer ReviewedFull Text
Summary of the ISFP congress, Brussels, 10–12 November, 2022
Author / Creator:Houeis, Lara ; Dolmans, Marie-Madeleine
Publisher:New York: Springer US
Journal title:Journal of assisted reproduction and genetics, 2023-03, Vol.40 (3), p.433-442
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Linzagolix: First Approval: Linzagolix: First Approval

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Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors

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Suppression of hypothalamic–pituitary–gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models

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Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials

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Suppressive effects of linzagolix, a novel non‐peptide antagonist of gonadotropin‐releasing hormone receptors, in experimental endometriosis model rats

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Uterine Adenomyosis Treated by Linzagolix, an Oral Gonadotropin-Releasing Hormone Receptor Antagonist: A Pilot Study with a New ’Hit Hard First and then Maintain’ Regimen of Administration

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Linzagolix: an oral gonadotropin-releasing hormone receptor antagonist treatment for uterine fibroid-associated heavy menstrual bleeding

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Profile of Linzagolix in the Management of Endometriosis, Including Design, Development and Potential Place in Therapy: A Narrative Review

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Linzagolix in moderate to severe symptoms of uterine fibroids: a profile of its use

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Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials

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Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents

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Linzagolix for treating moderate to severe symptoms of uterine fibroids

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Obseva Announced FDA Acceptance of NDA for Linzagolix

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ObsEva Presents Linzagolix Data From Uterine Fibroid Trials

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ObsEva Files US Application For Linzagolix For Uterine Fibroids

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ObsEva Announces Additional Efficacy Results For Linzagolix 200 mg With Add-Back Therapy And Linzagolix 75 mg Without ABT In Phase 3 EDELWEISS 3 Trial In Patients With Moderate-To-Severe Endometriosis...

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ObsEva Announced Topline Results for Linzagolix 200 mg with Add-Back Therapy in the Phase 3 EDELWEISS 3 Trial in Patients with Moderate-to-Severe Endometriosis-Associated Pain; Said Once Daily linzago...

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Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists

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GnRH Antagonists with or without Add-Back Therapy: A New Alternative in the Management of Endometriosis?

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Summary of the ISFP congress, Brussels, 10–12 November, 2022

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