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823 results for physiologically‐based+pharmacokinetic+modeling+(PBPK)

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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK: Physiologically Based Pharmacokinetic Modeling to Support Dose...
Author / Creator:Wagner, C. ; Zhao, P. ; Pan, Y. ; Hsu, V. ; Grillo, J. ; Huang, SM ; Sinha, V.
Publisher:United States: Wiley
Journal title:CPT: pharmacometrics and systems pharmacology, 2015-04, Vol.4 (4)
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SpatialCNS‐PBPK: An R/Shiny Web‐Based Application for Physiologically Based Pharmacokinetic Modeling of Spatial Pharmacokinetics in the Human Central Nervous System and Brain Tumors
Author / Creator:Wickramasinghe, Charuka D. ; Kim, Seongho ; Li, Jing
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2025-05, Vol.14 (5), p.864-880
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Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants
Author / Creator:Ganguly, Samit ; Edginton, Andrea N. ; Gerhart, Jacqueline G. ; Cohen-Wolkowiez, Michael ; Greenberg, Rachel G. ; Gonzalez, Daniel
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2021-12, Vol.60 (12), p.1591-1604
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Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Subst...
Author / Creator:Karrer, Cecile ; Roiss, Thomas ; von Goetz, Natalie ; Gramec Skledar, Darja ; Peterlin Mašič, Lucija ; Hungerbühler, Konrad
Publisher:United States: National Institute of Environmental Health Sciences
Journal title:Environmental health perspectives, 2018-07, Vol.126 (7), p.077002-077002
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Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization
Author / Creator:Cheng, Yi-Hsien ; Thomas, Sherin ; Tsang, Yu Chung ; Almeida, Susana ; Ashraf, Muhammad ; Fotaki, Nikoletta ; Heimbach, Tycho ; Patel, Nikunjkumar ; Shah, Harshil ; Jiang, Xiaojian ; Kim, Myong-Jin ; Moody, Rebecca ; Rostami‐Hodjegan, Amin ; Singh, Romi ; Zhao, Liang ; Babiskin, Andrew ; Wu, Fang
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2025-05, Vol.42 (5), p.819-833
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A Bottom-up Approach for Mutant and Wild Type Collies Using Physiologically Based Pharmacokinetic (PBPK) Modeling: A Case Study Using Loperamide
Author / Creator:Cross, Charlotte ; Martinez, Marilyn N. ; Pade, Devendra ; Myers, Michael J. ; Neuhoff, Sibylle
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2025-06, Vol.27 (4), p.101
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Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling
Author / Creator:Balhara, Ankit ; Ladumor, Mayur K. ; Nankar, Rakesh P. ; Syed, Samiulla Dodheri ; Giri, Sanjeev ; Prasad, Bhagwat ; Singh, Saranjit
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2022-04, Vol.39 (4), p.677-689
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Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse
Author / Creator:Chiu, Weihsueh A. ; Campbell, Jerry L. ; Clewell, Harvey J. ; Zhou, Yi-Hui ; Wright, Fred A. ; Guyton, Kathryn Z. ; Rusyn, Ivan
Publisher:United States: National Institute of Environmental Health Sciences
Journal title:Environmental health perspectives, 2014-05, Vol.122 (5), p.456-463
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Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict PET Image Quality of Three Generations EGFR TKI in Advanced-Stage NSCLC Patients
Author / Creator:Bartelink, I. ; van de Stadt, E. ; Leeuwerik, A. ; Thijssen, V. ; Hupsel, J. ; van den Nieuwendijk, J. ; Bahce, I. ; Yaqub, M. ; Hendrikse, N.
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceuticals (Basel, Switzerland), 2022-06, Vol.15 (7), p.796
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Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation
Author / Creator:Lee, Jeong-Min ; Yoon, Jin-Ha ; Maeng, Han-Joo ; Kim, Yu Chul
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2024-02, Vol.16 (2), p.280
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ArticlesPeer ReviewedFull Text
A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds
Author / Creator:Liu, Rongrui ; Zacharewski, Tim R. ; Conolly, Rory B. ; Zhang, Qiang
Publisher:Switzerland: MDPI AG
Journal title:Toxics (Basel), 2022-11, Vol.10 (11), p.700
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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach
Author / Creator:Fuhr, Laura Maria ; Marok, Fatima Zahra ; Hanke, Nina ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2021-02, Vol.13 (2), p.270
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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism
Author / Creator:Witta, Sandra ; Collins, Keagan P. ; Ramirez, Dominique A. ; Mannheimer, Joshua D. ; Wittenburg, Luke A. ; Gustafson, Daniel L.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Pharmacology research & perspectives, 2023-02, Vol.11 (1), p.e01052-n/a
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Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions
Author / Creator:Hanke, Nina ; Gómez-Mantilla, José David ; Ishiguro, Naoki ; Stopfer, Peter ; Nock, Valerie
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2021-10, Vol.38 (10), p.1645-1661
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Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies
Author / Creator:Liu, Shufang ; Shah, Dhaval K.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2023-04, Vol.25 (3), p.48-48, Article 48
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Physiologically-Based Pharmacokinetic Modeling and In Vitro–In Vivo Correlation of TV-46000 (Risperidone LAI): Prediction from Dog to Human
Author / Creator:Bibi, David ; Bilgraer, Raphael ; Steiner, Lilach ; Hallak, Hussein
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2024-07, Vol.16 (7), p.896
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Utility of physiologically based pharmacokinetic (PBPK) modeling in oncology drug development and its accuracy: a systematic review
Author / Creator:Saeheng, Teerachat ; Na-Bangchang, Kesara ; Karbwang, Juntra
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of clinical pharmacology, 2018-11, Vol.74 (11), p.1365-1376
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In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools
Author / Creator:Krstevska, Aleksandra ; Đuriš, Jelena ; Ibrić, Svetlana ; Cvijić, Sandra
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2022-12, Vol.15 (1), p.107
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Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling
Author / Creator:Coates, Shelby ; Bardhi, Keti ; Prasad, Bhagwat ; Lazarus, Philip
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2024-12, Vol.16 (12), p.1599
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Assessing Impact of Food on Oral Drug Bioequivalence Supporting ICH M13 A with the Advancements of Physiologically Based Pharmacokinetic Modeling
Author / Creator:Pal, Arindom ; Alam, Khondoker ; Stier, Ethan ; Heimbach, Tycho ; Cristofoletti, Rodrigo ; Al‐Gousous, Jozef ; Langguth, Peter ; Žakelj, Rebeka ; Ahmed, Tausif ; Almeida, Susana ; Fan, Jianghong ; Kolhatkar, Vidula ; Paixão, Paulo ; Rayeni, Mohan Krishna ; Zhang, Lei ; Wu, Fang
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2025-05, Vol.42 (5), p.835-845
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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK: Physiologically Based Pharmacokinetic Modeling to Support Dose...

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SpatialCNS‐PBPK: An R/Shiny Web‐Based Application for Physiologically Based Pharmacokinetic Modeling of Spatial Pharmacokinetics in the Human Central Nervous System and Brain Tumors

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Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants

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Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Subst...

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Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization

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A Bottom-up Approach for Mutant and Wild Type Collies Using Physiologically Based Pharmacokinetic (PBPK) Modeling: A Case Study Using Loperamide

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Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

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Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict PET Image Quality of Three Generations EGFR TKI in Advanced-Stage NSCLC Patients

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Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation

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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

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Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions

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Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies

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Physiologically-Based Pharmacokinetic Modeling and In Vitro–In Vivo Correlation of TV-46000 (Risperidone LAI): Prediction from Dog to Human

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Utility of physiologically based pharmacokinetic (PBPK) modeling in oncology drug development and its accuracy: a systematic review

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In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

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Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling

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Assessing Impact of Food on Oral Drug Bioequivalence Supporting ICH M13 A with the Advancements of Physiologically Based Pharmacokinetic Modeling

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