MECOM promotes leukemia progression and inhibits mast cell differentiation through functional compet...
MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2
About this item
Full title
Author / Creator
Publisher
Cold Spring Harbor Laboratory
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor Laboratory
Subjects
More information
Scope and Contents
Contents
MECOM is a nuclear transcription factor essential for the proliferation of hematopoietic stem cells (HSCs) and myeloid leukemia cells. MECOM contains N- and C-terminal zinc finger domains (ZFDs) and binding motifs for the corepressor CtBP to regulate gene expression. Recent studies have shown that germline MECOM variants are associated with thrombo...
Alternative Titles
Full title
MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_biorxiv_primary_2024_05_20_594903
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2024_05_20_594903
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2024.05.20.594903
