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ArticlesPeer ReviewedFull Text
The role of ASXL1 in hematopoiesis and myeloid malignancies
Author / Creator:Asada, Shuhei ; Fujino, Takeshi ; Goyama, Susumu ; Kitamura, Toshio
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2019-07, Vol.76 (13), p.2511-2523
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Epigenetics in normal and malignant hematopoiesis: An overview and update 2017
Author / Creator:Goyama, Susumu ; Kitamura, Toshio
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2017-04, Vol.108 (4), p.553-562
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Mechanisms involved in hematopoietic stem cell aging
Author / Creator:Fujino, Takeshi ; Asada, Shuhei ; Goyama, Susumu ; Kitamura, Toshio
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2022-09, Vol.79 (9), p.473-473, Article 473
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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
Author / Creator:Fujino, Takeshi ; Goyama, Susumu ; Sugiura, Yuki ; Inoue, Daichi ; Asada, Shuhei ; Yamasaki, Satoshi ; Matsumoto, Akiko ; Yamaguchi, Kiyoshi ; Isobe, Yumiko ; Tsuchiya, Akiho ; Shikata, Shiori ; Sato, Naru ; Morinaga, Hironobu ; Fukuyama, Tomofusa ; Tanaka, Yosuke ; Fukushima, Tsuyoshi ; Takeda, Reina ; Yamamoto, Keita ; Honda, Hiroaki ; Nishimura, Emi K. ; Furukawa, Yoichi ; Shibata, Tatsuhiro ; Abdel-Wahab, Omar ; Suematsu, Makoto ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1826-20, Article 1826
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CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression
Author / Creator:Liu, Xiaoxiao ; Sato, Naru ; Shimosato, Yuko ; Wang, Teh‐Wei ; Denda, Tamami ; Chang, Yu‐Hsuan ; Yabushita, Tomohiro ; Fujino, Takeshi ; Asada, Shuhei ; Tanaka, Yosuke ; Fukuyama, Tomofusa ; Enomoto, Yutaka ; Ota, Yasunori ; Sakamoto, Takeharu ; Kitamura, Toshio ; Goyama, Susumu
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2022-04, Vol.113 (4), p.1182-1194
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PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
Author / Creator:Kawashima, Masaharu ; Carreras, Joaquim ; Higuchi, Hiroshi ; Kotaki, Ryutaro ; Hoshina, Takahiro ; Okuyama, Kazuki ; Suzuki, Naoto ; Kakizaki, Masatoshi ; Miyatake, Yuji ; Ando, Kiyoshi ; Nakayama, Masafumi ; Umezu, Shinjiro ; Horie, Ryouichi ; Higuchi, Yuriko ; Katagiri, Koko ; Goyama, Susumu ; Kitamura, Toshio ; Chamoto, Kenji ; Yano, Shingo ; Nakamura, Naoya ; Kotani, Ai
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2020-09, Vol.34 (9), p.2405-2417
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ArticlesPeer ReviewedFull Text
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
Author / Creator:Asada, Shuhei ; Goyama, Susumu ; Inoue, Daichi ; Shikata, Shiori ; Takeda, Reina ; Fukushima, Tsuyoshi ; Yonezawa, Taishi ; Fujino, Takeshi ; Hayashi, Yasutaka ; Kawabata, Kimihito Cojin ; Fukuyama, Tomofusa ; Tanaka, Yosuke ; Yokoyama, Akihiko ; Yamazaki, Satoshi ; Kozuka-Hata, Hiroko ; Oyama, Masaaki ; Kojima, Shinya ; Kawazu, Masahito ; Mano, Hiroyuki ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-07, Vol.9 (1), p.2733-18, Article 2733
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Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
Author / Creator:Tanaka, Yosuke ; Takeda, Reina ; Fukushima, Tsuyoshi ; Mikami, Keiko ; Tsuchiya, Shun ; Tamura, Moe ; Adachi, Keito ; Umemoto, Terumasa ; Asada, Shuhei ; Watanabe, Naoki ; Morishita, Soji ; Imai, Misa ; Nagata, Masayoshi ; Araki, Marito ; Takizawa, Hitoshi ; Fukuyama, Tomofusa ; Lamagna, Chrystelle ; Masuda, Esteban S. ; Ito, Ryoji ; Goyama, Susumu ; Komatsu, Norio ; Takaku, Tomoiku ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-01, Vol.13 (1), p.271-271, Article 271
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ArticlesPeer ReviewedFull Text
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Author / Creator:Backx, Elyne ; Wauters, Elke ; Baldan, Jonathan ; Van Bulck, Mathias ; Michiels, Ellis ; Heremans, Yves ; De Paep, Diedert Luc ; Kurokawa, Mineo ; Goyama, Susumu ; Bouwens, Luc ; Jacquemin, Patrick ; Houbracken, Isabelle ; Rooman, Ilse
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2021-09, Vol.28 (9), p.2601-2615
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ArticlesPeer ReviewedFull Text
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
Author / Creator:Goyama, Susumu ; Schibler, Janet ; Cunningham, Lea ; Zhang, Yue ; Rao, Yalan ; Nishimoto, Nahoko ; Nakagawa, Masahiro ; Olsson, Andre ; Wunderlich, Mark ; Link, Kevin A. ; Mizukawa, Benjamin ; Grimes, H. Leighton ; Kurokawa, Mineo ; Liu, P. Paul ; Huang, Gang ; Mulloy, James C.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-09, Vol.123 (9), p.3876-3888
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Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
Author / Creator:Hayashi, Yasutaka ; Goyama, Susumu ; Liu, XiaoXiao ; Tamura, Moe ; Asada, Shuhei ; Tanaka, Yosuke ; Fukuyama, Tomofusa ; Wunderlich, Mark ; O’Brien, Eric ; Mizukawa, Benjamin ; Yamazaki, Satoshi ; Matsumoto, Akiko ; Yamasaki, Satoshi ; Shibata, Tatsuhiro ; Matsuda, Koichi ; Sashida, Goro ; Takizawa, Hitoshi ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-10, Vol.10 (1), p.4869-14, Article 4869
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Pathogenetic significance of ecotropic viral integration site‐1 in hematological malignancies
Author / Creator:Goyama, Susumu ; Kurokawa, Mineo
Publisher:Melbourne, Australia: Blackwell Publishing Asia
Journal title:Cancer science, 2009-06, Vol.100 (6), p.990-995
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BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state
Author / Creator:Xiao, Muran ; Kondo, Shinji ; Nomura, Masaki ; Kato, Shinichiro ; Nishimura, Koutarou ; Zang, Weijia ; Zhang, Yifan ; Akashi, Tomohiro ; Viny, Aaron ; Shigehiro, Tsukasa ; Ikawa, Tomokatsu ; Yamazaki, Hiromi ; Fukumoto, Miki ; Tanaka, Atsushi ; Hayashi, Yasutaka ; Koike, Yui ; Aoyama, Yumi ; Ito, Hiromi ; Nishikawa, Hiroyoshi ; Kitamura, Toshio ; Kanai, Akinori ; Yokoyama, Akihiko ; Fujiwara, Tohru ; Goyama, Susumu ; Noguchi, Hideki ; Lee, Stanley C. ; Toyoda, Atsushi ; Hinohara, Kunihiko ; Abdel-Wahab, Omar ; Inoue, Daichi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-12, Vol.14 (1), p.8372-22, Article 8372
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Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects
Author / Creator:Goyama, Susumu ; Mulloy, James C.
Publisher:Tokyo: Springer Japan
Journal title:International journal of hematology, 2011-08, Vol.94 (2), p.126-133
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Opposing effects of acute versus chronic inhibition of p53 on decitabine’s efficacy in myeloid neoplasms
Author / Creator:Tamura, Moe ; Yonezawa, Taishi ; Liu, Xiaoxiao ; Asada, Shuhei ; Hayashi, Yasutaka ; Fukuyama, Tomofusa ; Tanaka, Yosuke ; Kitamura, Toshio ; Goyama, Susumu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-06, Vol.9 (1), p.8171, Article 8171
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A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies
Author / Creator:Inoue, Daichi ; Fujino, Takeshi ; Sheridan, Paul ; Zhang, Yao-zhong ; Nagase, Reina ; Horikawa, Sayuri ; Li, Zaomin ; Matsui, Hirotaka ; Kanai, Akinori ; Saika, Makoto ; Yamaguchi, Rui ; Kozuka-Hata, Hiroko ; Kawabata, Kimihito Cojin ; Yokoyama, Akihiko ; Goyama, Susumu ; Inaba, Toshiya ; Imoto, Seiya ; Miyano, Satoru ; Xu, Mingjiang ; Yang, Feng-Chun ; Oyama, Masaaki ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2018-06, Vol.32 (6), p.1327-1337
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CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations
Author / Creator:Fukushima, Tsuyoshi ; Tanaka, Yosuke ; Adachi, Keito ; Masuyama, Nanami ; Tsuchiya, Akiho ; Asada, Shuhei ; Ishiguro, Soh ; Mori, Hideto ; Seki, Motoaki ; Yachie, Nozomu ; Goyama, Susumu ; Kitamura, Toshio
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-12, Vol.11 (1), p.23889-23889, Article 23889
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Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization
Author / Creator:Kaito, Satoshi ; Aoyama, Kazumasa ; Oshima, Motohiko ; Tsuchiya, Akiho ; Miyota, Makiko ; Yamashita, Masayuki ; Koide, Shuhei ; Nakajima-Takagi, Yaeko ; Kozuka-Hata, Hiroko ; Oyama, Masaaki ; Yogo, Takao ; Yabushita, Tomohiro ; Ito, Ryoji ; Ueno, Masaya ; Hirao, Atsushi ; Tohyama, Kaoru ; Li, Chao ; Kawabata, Kimihito Cojin ; Yamaguchi, Kiyoshi ; Furukawa, Yoichi ; Kosako, Hidetaka ; Yoshimi, Akihide ; Goyama, Susumu ; Nannya, Yasuhito ; Ogawa, Seishi ; Agger, Karl ; Helin, Kristian ; Yamazaki, Satoshi ; Koseki, Haruhiko ; Doki, Noriko ; Harada, Yuka ; Harada, Hironori ; Nishiyama, Atsuya ; Nakanishi, Makoto ; Iwama, Atsushi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.7359-18, Article 7359
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ArticlesPeer ReviewedFull Text
The effect of iron overload and chelation on erythroid differentiation
Author / Creator:Taoka, Kazuki ; Kumano, Keiki ; Nakamura, Fumihiko ; Hosoi, Masataka ; Goyama, Susumu ; Imai, Yoichi ; Hangaishi, Akira ; Kurokawa, Mineo
Publisher:Japan: Springer Japan
Journal title:International journal of hematology, 2012-02, Vol.95 (2), p.149-159
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IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia
Author / Creator:Liu, Xiaoxiao ; Sato, Naru ; Yabushita, Tomohiro ; Li, Jingmei ; Jia, Yuhan ; Tamura, Moe ; Asada, Shuhei ; Fujino, Takeshi ; Fukushima, Tsuyoshi ; Yonezawa, Taishi ; Tanaka, Yosuke ; Fukuyama, Tomofusa ; Tsuchiya, Akiho ; Shikata, Shiori ; Iwamura, Hiroyuki ; Kinouchi, Chieko ; Komatsu, Kensuke ; Yamasaki, Satoshi ; Shibata, Tatsuhiro ; Sasaki, Atsuo T ; Schibler, Janet ; Wunderlich, Mark ; O'Brien, Eric ; Mizukawa, Benjamin ; Mulloy, James C ; Sugiura, Yuki ; Takizawa, Hitoshi ; Shibata, Takuma ; Miyake, Kensuke ; Kitamura, Toshio ; Goyama, Susumu
Publisher:England: EMBO Press
Journal title:EMBO molecular medicine, 2023-01, Vol.15 (1), p.e15631-n/a
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Showing 1 to 20 of 36 results

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The role of ASXL1 in hematopoiesis and myeloid malignancies

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Epigenetics in normal and malignant hematopoiesis: An overview and update 2017

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Mechanisms involved in hematopoietic stem cell aging

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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

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CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression

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PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma

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Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

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Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

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MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

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Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

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Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

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Pathogenetic significance of ecotropic viral integration site‐1 in hematological malignancies

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BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state

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Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects

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Opposing effects of acute versus chronic inhibition of p53 on decitabine’s efficacy in myeloid neoplasms

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A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

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CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations

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Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

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The effect of iron overload and chelation on erythroid differentiation

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IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

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