The Protofilament Structure of Insulin Amyloid Fibrils
The Protofilament Structure of Insulin Amyloid Fibrils
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Under solution conditions where the native state is destabilized, the largely helical polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic cross-β structure. However, there is a lack of information relating the 4.8 Å, β-strand repeat to the higher order assembly of amyloid fibrils. We have used cryo-electron...
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Full title
The Protofilament Structure of Insulin Amyloid Fibrils
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TN_cdi_crossref_citationtrail_10_1073_pnas_142459399
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_142459399
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.142459399
