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ArticlesPeer ReviewedFull Text
2.7 Å cryo-EM structure of ex vivo RML prion fibrils
Author / Creator:Manka, Szymon W. ; Zhang, Wenjuan ; Wenborn, Adam ; Betts, Jemma ; Joiner, Susan ; Saibil, Helen R. ; Collinge, John ; Wadsworth, Jonathan D. F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-07, Vol.13 (1), p.4004-11, Article 4004
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A structural basis for prion strain diversity
Author / Creator:Manka, Szymon W. ; Wenborn, Adam ; Betts, Jemma ; Joiner, Susan ; Saibil, Helen R. ; Collinge, John ; Wadsworth, Jonathan D. F.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2023-05, Vol.19 (5), p.607-613
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Structural basis for the regulated protease and chaperone function of DegP
Author / Creator:Krojer, Tobias ; Sawa, Justyna ; Schäfer, Eva ; Saibil, Helen R. ; Ehrmann, Michael ; Clausen, Tim
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2008-06, Vol.453 (7197), p.885-890
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Blob-ology and biology of cryo-EM: an interview with Helen Saibil
Author / Creator:Saibil, Helen R.
Publisher:England: BioMed Central Ltd
Journal title:BMC biology, 2017-08, Vol.15 (1), p.77-77, Article 77
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Direct three-dimensional visualization of membrane disruption by amyloid fibrils
Author / Creator:Milanesi, Lilia ; Sheynis, Tania ; Xue, Wei-Feng ; Orlova, Elena V ; Hellewell, Andrew L ; Jelinek, Raz ; Hewitt, Eric W ; Radford, Sheena E ; Saibil, Helen R
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (50), p.20455-20460
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Real-time visualization of perforin nanopore assembly
Author / Creator:Leung, Carl ; Hodel, Adrian W. ; Brennan, Amelia J. ; Lukoyanova, Natalya ; Tran, Sharon ; House, Colin M. ; Kondos, Stephanie C. ; Whisstock, James C. ; Dunstone, Michelle A. ; Trapani, Joseph A. ; Voskoboinik, Ilia ; Saibil, Helen R. ; Hoogenboom, Bart W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature nanotechnology, 2017-05, Vol.12 (5), p.467-473
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Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites
Author / Creator:Hart, Melissa N. ; Mohring, Franziska ; DonVito, Sophia M. ; Thomas, James A. ; Muller-Sienerth, Nicole ; Wright, Gavin J. ; Knuepfer, Ellen ; Saibil, Helen R. ; Moon, Robert W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-08, Vol.14 (1), p.4619-4619, Article 4619
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Structure of the poly-C9 component of the complement membrane attack complex
Author / Creator:Dudkina, Natalya V. ; Spicer, Bradley A. ; Reboul, Cyril F. ; Conroy, Paul J. ; Lukoyanova, Natalya ; Elmlund, Hans ; Law, Ruby H. P. ; Ekkel, Susan M. ; Kondos, Stephanie C. ; Goode, Robert J. A. ; Ramm, Georg ; Whisstock, James C. ; Saibil, Helen R. ; Dunstone, Michelle A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-02, Vol.7 (1), p.10588-10588, Article 10588
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The structural basis for membrane binding and pore formation by lymphocyte perforin
Author / Creator:Law, Ruby H. P. ; Lukoyanova, Natalya ; Voskoboinik, Ilia ; Caradoc-Davies, Tom T. ; Baran, Katherine ; Dunstone, Michelle A. ; D’Angelo, Michael E. ; Orlova, Elena V. ; Coulibaly, Fasséli ; Verschoor, Sandra ; Browne, Kylie A. ; Ciccone, Annette ; Kuiper, Michael J. ; Bird, Phillip I. ; Trapani, Joseph A. ; Saibil, Helen R. ; Whisstock, James C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-11, Vol.468 (7322), p.447-451
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Structure of a Type IV Secretion System Core Complex
Author / Creator:Fronzes, Rémi ; Schäfer, Eva ; Wang, Luchun ; Saibil, Helen R ; Orlova, Elena V ; Waksman, Gabriel
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2009-01, Vol.323 (5911), p.266-268
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Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro
Author / Creator:Terry, Cassandra ; Harniman, Robert L. ; Sells, Jessica ; Wenborn, Adam ; Joiner, Susan ; Saibil, Helen R. ; Miles, Mervyn J. ; Collinge, John ; Wadsworth, Jonathan D. F.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-01, Vol.9 (1), p.376-376, Article 376
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Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Author / Creator:Lukoyanova, Natalya ; Kondos, Stephanie C. ; Farabella, Irene ; Law, Ruby H. P. ; Reboul, Cyril F. ; Caradoc-Davies, Tom T. ; Spicer, Bradley A. ; Kleifeld, Oded ; Traore, Daouda A. K. ; Ekkel, Susan M. ; Voskoboinik, Ilia ; Trapani, Joseph A. ; Hatfaludi, Tamas ; Oliver, Katherine ; Hotze, Eileen M. ; Tweten, Rodney K. ; Whisstock, James C. ; Topf, Maya ; Saibil, Helen R. ; Dunstone, Michelle A.
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2015-02, Vol.13 (2), p.e1002049
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Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation
Author / Creator:Carroni, Marta ; Kummer, Eva ; Oguchi, Yuki ; Wendler, Petra ; Clare, Daniel K ; Sinning, Irmgard ; Kopp, Jürgen ; Mogk, Axel ; Bukau, Bernd ; Saibil, Helen R
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2014-04, Vol.3, p.e02481-e02481
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Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
Author / Creator:Leung, Carl ; Dudkina, Natalya V ; Lukoyanova, Natalya ; Hodel, Adrian W ; Farabella, Irene ; Pandurangan, Arun P ; Jahan, Nasrin ; Pires Damaso, Mafalda ; Osmanović, Dino ; Reboul, Cyril F ; Dunstone, Michelle A ; Andrew, Peter W ; Lonnen, Rana ; Topf, Maya ; Saibil, Helen R ; Hoogenboom, Bart W
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2014-12, Vol.3, p.e04247
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Structural journey of an insecticidal protein against western corn rootworm
Author / Creator:Marini, Guendalina ; Poland, Brad ; Leininger, Chris ; Lukoyanova, Natalya ; Spielbauer, Dan ; Barry, Jennifer K. ; Altier, Dan ; Lum, Amy ; Scolaro, Eric ; Ortega, Claudia Pérez ; Yalpani, Nasser ; Sandahl, Gary ; Mabry, Tim ; Klever, Jeffrey ; Nowatzki, Timothy ; Zhao, Jian-Zhou ; Sethi, Amit ; Kassa, Adane ; Crane, Virginia ; Lu, Albert L. ; Nelson, Mark E. ; Eswar, Narayanan ; Topf, Maya ; Saibil, Helen R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-07, Vol.14 (1), p.4171-4171, Article 4171
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Stepwise recruitment of chaperone Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibril disassembly
Author / Creator:Monistrol, Jim ; Beton, Joseph G. ; Johnston, Erin C. ; Dang, Thi Lieu ; Bukau, Bernd ; Saibil, Helen R.
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2025-03, Vol.8 (1), p.522-15, Article 522
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A novel and rapid method for obtaining high titre intact prion strains from mammalian brain
Author / Creator:Wenborn, Adam ; Terry, Cassandra ; Gros, Nathalie ; Joiner, Susan ; D’Castro, Laura ; Panico, Silvia ; Sells, Jessica ; Cronier, Sabrina ; Linehan, Jacqueline M. ; Brandner, Sebastian ; Saibil, Helen R. ; Collinge, John ; Wadsworth, Jonathan D. F.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-05, Vol.5 (1), p.10062-10062, Article 10062
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The Protofilament Structure of Insulin Amyloid Fibrils
Author / Creator:Jiménez, José L. ; Nettleton, Ewan J. ; Bouchard, Mario ; Robinson, Carol V. ; Dobson, Christopher M. ; Saibil, Helen R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9196-9201
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Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
Author / Creator:Malet, Hélène ; Canellas, Flavia ; Sawa, Justyna ; Yan, Jun ; Thalassinos, Konstantinos ; Ehrmann, Michael ; Clausen, Tim ; Saibil, Helen R
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2012-02, Vol.19 (2), p.152-157
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The TatA Component of the Twin-Arginine Protein Transport System Forms Channel Complexes of Variable Diameter
Author / Creator:Gohlke, Ulrich ; Pullan, Lee ; McDevitt, Christopher A. ; Porcelli, Ida ; de Leeuw, Erik ; Palmer, Tracy ; Saibil, Helen R. ; Berks, Ben C. ; Wickner, William T.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (30), p.10482-10486
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2.7 Å cryo-EM structure of ex vivo RML prion fibrils

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A structural basis for prion strain diversity

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Structural basis for the regulated protease and chaperone function of DegP

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Blob-ology and biology of cryo-EM: an interview with Helen Saibil

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Direct three-dimensional visualization of membrane disruption by amyloid fibrils

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Real-time visualization of perforin nanopore assembly

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Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites

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Structure of the poly-C9 component of the complement membrane attack complex

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The structural basis for membrane binding and pore formation by lymphocyte perforin

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Structure of a Type IV Secretion System Core Complex

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Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

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Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

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Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

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Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

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Structural journey of an insecticidal protein against western corn rootworm

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Stepwise recruitment of chaperone Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibril disassembly

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A novel and rapid method for obtaining high titre intact prion strains from mammalian brain

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The Protofilament Structure of Insulin Amyloid Fibrils

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Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

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The TatA Component of the Twin-Arginine Protein Transport System Forms Channel Complexes of Variable Diameter

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