Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates th...
Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression
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Basingstoke: Elsevier Inc
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Language
English
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Publisher
Basingstoke: Elsevier Inc
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Contents
Transforming growth factor-β2 (TGF-β2) stimulates the expression of pro-fibrotic connective tissue growth factor (CTGF) during the course of renal disease. Because sphingosine kinase-1 (SK-1) activity is also upregulated by TGF-β, we studied its effect on CTGF expression and on the development of renal fibrosis. When TGF-β2 was added to an immortal...
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Full title
Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression
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TN_cdi_crossref_primary_10_1038_ki_2009_297
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1038_ki_2009_297
Other Identifiers
ISSN
0085-2538
E-ISSN
1523-1755
DOI
10.1038/ki.2009.297
