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Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1056_NEJMc1703047

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

About this item

Full title

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

Publisher

United States: Massachusetts Medical Society

Journal title

The New England journal of medicine, 2017-05, Vol.376 (20), p.1989-1991

Language

English

Formats

Publication information

Publisher

United States: Massachusetts Medical Society

More information

Scope and Contents

Contents

In a patient with colon cancer and a history of autoimmunity, skin and gastrointestinal toxicity developed after the receipt of pembrolizumab. Interleukin-17 blockade reversed the autoimmunity but led to tumor progression.
To the Editor:
Patients with autoimmune diseases have typically been excluded from immunotherapy clinical trials, althoug...

Alternative Titles

Full title

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1056_NEJMc1703047

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1056_NEJMc1703047

Other Identifiers

ISSN

0028-4793

E-ISSN

1533-4406

DOI

10.1056/NEJMc1703047

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