Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-β peptide and...
Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-β peptide and neuronal cell interactions
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
By using a highly sensitive technique of atomic force microscopy-based single-cell compression, the rigidity of cultured N2a and HT22 neuronal cells was measured as a function of amyloid-β42 (Aβ42) protein treatment. Aβ42 oligomers led to significant cellular stiffening; for example, 90-360% higher force was required to reach 80% deformation for N2...
Alternative Titles
Full title
Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-β peptide and neuronal cell interactions
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1008341107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1008341107
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1008341107
