Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphoryla...
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesions of AD, but their temporal me...
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Full title
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
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TN_cdi_crossref_primary_10_1073_pnas_1017033108
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1017033108
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1017033108
