CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of G...
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Emerging genetic and clinical evidence suggests a link between Gaucher disease and the synucleinopathies Parkinson disease and dementia with Lewy bodies. Here, we provide evidence that a mouse model of Gaucher disease (Gba1D409V/D409V) exhibits characteristics of synucleinopathies, including progressive accumulation of proteinase K-resistant α-synu...
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Full title
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
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TN_cdi_crossref_primary_10_1073_pnas_1108197108
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1108197108
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1108197108
