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ArticlesPeer ReviewedFull Text
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
Author / Creator:Liu, Xiaona ; Chhipa, Rishi Raj ; Pooya, Shabnam ; Wortman, Matthew ; Yachyshin, Sara ; Chow, Lionel M. L. ; Kumar, Ashish ; Zhou, Xuan ; Sun, Ying ; Quinn, Brian ; McPherson, Christopher ; Warnick, Ronald E. ; Kendler, Ady ; Giri, Shailendra ; Poels, Jeroen ; Norga, Koenraad ; Viollet, Benoit ; Grabowski, Gregory A. ; Dasgupta, Biplab
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (4), p.1235-1235
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ArticlesPeer ReviewedFull Text
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease
Author / Creator:Marshall, John ; Sun, Ying ; Bangari, Dinesh S ; Budman, Eva ; Park, Hyejung ; Nietupski, Jennifer B ; Allaire, Amy ; Cromwell, Mary A ; Wang, Bing ; Grabowski, Gregory A ; Leonard, John P ; Cheng, Seng H
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2016-06, Vol.24 (6), p.1019-1029
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ArticlesPeer ReviewedFull Text
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
Author / Creator:Sardi, S. Pablo ; Clarke, Jennifer ; Kinnecom, Cathrine ; Tamsett, Thomas J. ; Li, Lingyun ; Stanek, Lisa M. ; Passini, Marco A. ; Grabowski, Gregory A. ; Schlossmacher, Michael G. ; Sidman, Richard L. ; Cheng, Seng H. ; Shihabuddin, Lamya S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12101-12106
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ArticlesPeer ReviewedFull Text
Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology
Author / Creator:Sun, Ying ; Florer, Jane ; Mayhew, Christopher N. ; Jia, Zhanfeng ; Zhao, Zhiying ; Xu, Kui ; Ran, Huimin ; Liou, Benjamin ; Zhang, Wujuan ; Setchell, Kenneth D. R. ; Gu, Jianguo ; Grabowski, Gregory A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0118771-e0118771
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ArticlesPeer ReviewedFull Text
Phenotype, diagnosis, and treatment of Gaucher's disease
Author / Creator:Grabowski, Gregory A, Dr
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2008-10, Vol.372 (9645), p.1263-1271
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ArticlesPeer ReviewedFull Text
Lysosomal Storage Disease 1 Phenotype, diagnosis, and treatment of Gaucher's disease
Author / Creator:GRABOWSKI, Gregory A
Publisher:London: Lancet
Journal title:The Lancet (British edition), 2008-10, Vol.372 (9645), p.1263-1271
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ArticlesPeer ReviewedFull Text
Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse
Author / Creator:Sun, Ying ; Ran, Huimin ; Liou, Benjamin ; Quinn, Brian ; Zamzow, Matt ; Zhang, Wujuan ; Bielawski, Jacek ; Kitatani, Kazuyuki ; Setchell, Kenneth D. R. ; Hannun, Yusuf A. ; Grabowski, Gregory A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-04, Vol.6 (4), p.e19037-e19037
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ArticlesPeer ReviewedFull Text
Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease
Author / Creator:Dai, Mei ; Liou, Benjamin ; Swope, Brittany ; Wang, Xiaohong ; Zhang, Wujuan ; Inskeep, Venette ; Grabowski, Gregory A. ; Sun, Ying ; Pan, Dao
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-09, Vol.11 (9), p.e0162367-e0162367
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ArticlesPeer ReviewedFull Text
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
Author / Creator:Pandey, Manoj K. ; Burrow, Thomas A. ; Rani, Reena ; Martin, Lisa J. ; Witte, David ; Setchell, Kenneth D. ; Mckay, Mary A. ; Magnusen, Albert F. ; Zhang, Wujuan ; Liou, Benjamin ; Köhl, Jörg ; Grabowski, Gregory A.
Publisher:Nature Publishing Group
Journal title:Nature (London), 2017-03, Vol.543 (7643), p.108-112
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ArticlesPeer ReviewedFull Text
Substrate Compositional Variation with Tissue/Region and Gba1 Mutations in Mouse Models–Implications for Gaucher Disease
Author / Creator:Sun, Ying ; Zhang, Wujuan ; Xu, You-Hai ; Quinn, Brian ; Dasgupta, Nupur ; Liou, Benjamin ; Setchell, Kenneth D. R. ; Grabowski, Gregory A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e57560
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ArticlesPeer ReviewedFull Text
Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model
Author / Creator:Barnes, Sonya ; Xu, You-Hai ; Zhang, Wujuan ; Liou, Benjamin ; Setchell, Kenneth D. R. ; Bao, Liming ; Grabowski, Gregory A. ; Sun, Ying
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-12, Vol.9 (12), p.e116023-e116023
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ArticlesPeer ReviewedFull Text
Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease
Author / Creator:Kitatani, Kazuyuki ; Wada, Masayuki ; Perry, David ; Usui, Toshinori ; Sun, Ying ; Obeid, Lina M. ; Yaegashi, Nobuo ; Grabowski, Gregory A. ; Hannun, Yusuf A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-08, Vol.10 (8), p.e0136633-e0136633
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ArticlesPeer ReviewedFull Text
Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher Disease
Author / Creator:Peng, Yanyan ; Liou, Benjamin ; Lin, Yi ; Fannin, Venette ; Zhang, Wujuan ; Feldman, Ricardo A. ; Setchell, Kenneth D. R. ; Grabowski, Gregory A. ; Sun, Ying
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-09, Vol.10 (9), p.2286
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ArticlesPeer ReviewedFull Text
Comparative Therapeutic Effects of Velaglucerase Alfa and Imiglucerase in a Gaucher Disease Mouse Model
Author / Creator:Xu, You-Hai ; Sun, Ying ; Barnes, Sonya ; Grabowski, Gregory A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-05, Vol.5 (5), p.e10750
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ArticlesPeer ReviewedFull Text
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins
Author / Creator:Zhou, Dapeng ; Cantu, Carlos ; Sagiv, Yuval ; Schrantz, Nicolas ; Kulkarni, Ashok B. ; Qi, Xiaoyang ; Mahuran, Don J. ; Morales, Carlos R. ; Grabowski, Gregory A. ; Benlagha, Kamel ; Savage, Paul ; Bendelac, Albert ; Teyton, Luc
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2004-01, Vol.303 (5657), p.523-527
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ArticlesPeer ReviewedFull Text
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation
Author / Creator:León, Luis ; Tatituri, Raju V. V ; Grenha, Rosa ; Sun, Ying ; Barral, Duarte C ; Minnaard, Adriaan J ; Bhowruth, Veemal ; Veerapen, Natacha ; Besra, Gurdyal S ; Kasmar, Anne ; Peng, Wei ; Moody, D. Branch ; Grabowski, Gregory A ; Brenner, Michael B
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (12), p.4357-4364
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ArticlesPeer ReviewedFull Text
Gaucher Disease: Transcriptome Analyses Using Microarray or mRNA Sequencing in a Gba1 Mutant Mouse Model Treated with Velaglucerase alfa or Imiglucerase
Author / Creator:Dasgupta, Nupur ; Xu, You-Hai ; Oh, Sunghee ; Sun, Ying ; Jia, Li ; Keddache, Mehdi ; Grabowski, Gregory A
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e74912
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ArticlesPeer ReviewedFull Text
Global gene expression profile progression in Gaucher disease mouse models
Author / Creator:Xu, You-Hai ; Jia, Li ; Quinn, Brian ; Zamzow, Matthew ; Stringer, Keith ; Aronow, Bruce ; Sun, Ying ; Zhang, Wujuan ; Setchell, Kenneth DR ; Grabowski, Gregory A
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2011-01, Vol.12 (1), p.20-20, Article 20
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ArticlesPeer ReviewedFull Text
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
Author / Creator:Pandey, Manoj K. ; Burrow, Thomas A. ; Rani, Reena ; Martin, Lisa J. ; Witte, David ; Setchell, Kenneth D. ; Mckay, Mary A. ; Magnusen, Albert F. ; Zhang, Wujuan ; Liou, Benjamin ; Köhl, Jörg ; Grabowski, Gregory A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-03, Vol.543 (7643), p.108-112
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Newsletter articlesFull Text
Biomedicine; New Enzyme Replacement Therapy Study Results Reported from W.V. Brown et al (JCL Roundtable: Enzyme replacement therapy for lipid storage disorders)
Publisher:Atlanta: NewsRx
Journal title:Biotech Week, 2014, p.146
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Showing 1 to 20 of 51 results

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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

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CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease

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CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

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Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology

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Phenotype, diagnosis, and treatment of Gaucher's disease

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Lysosomal Storage Disease 1 Phenotype, diagnosis, and treatment of Gaucher's disease

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Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse

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Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

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Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

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Substrate Compositional Variation with Tissue/Region and Gba1 Mutations in Mouse Models–Implications for Gaucher Disease

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Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model

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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

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Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher Disease

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Comparative Therapeutic Effects of Velaglucerase Alfa and Imiglucerase in a Gaucher Disease Mouse Model

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Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins

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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

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Gaucher Disease: Transcriptome Analyses Using Microarray or mRNA Sequencing in a Gba1 Mutant Mouse Model Treated with Velaglucerase alfa or Imiglucerase

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Global gene expression profile progression in Gaucher disease mouse models

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Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

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Biomedicine; New Enzyme Replacement Therapy Study Results Reported from W.V. Brown et al (JCL Roundtable: Enzyme replacement therapy for lipid storage disorders)

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