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Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1217207109

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

About this item

Full title

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (47), p.19059-19060

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Broadly neutralizing HIV antibodies (bNAbs) can recognize carbohydrate-dependent epitopes on gp120. In contrast to previously characterized glycan-dependent bNAbs that recognize high-mannose N -glycans, PGT121 binds complex-type N -glycans in glycan microarrays. We isolated the B-cell clone encoding PGT121, which segregates into PGT121-like and 10-...

Alternative Titles

Full title

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1217207109

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1217207109

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1217207109

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