Prostaglandin E 2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and...
Prostaglandin E 2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes
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English
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Aspirin-exacerbated respiratory disease (AERD) is a common, severe variant of asthma, which is associated with overproduction of cysteinyl leukotrienes (cysLTs) and respiratory reactions to drugs that block cyclooxygenase 1. We demonstrate that mice selectively lacking the capacity to up-regulate the generation of prostaglandin E
2
with infla...
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Prostaglandin E 2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes
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TN_cdi_crossref_primary_10_1073_pnas_1313185110
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1313185110
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1313185110
