Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases bindin...
Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The Notch signaling pathway is essential for many aspects of development, cell fate determination, and tissue homeostasis. Notch signaling can be modulated by posttranslational modifications to the Notch receptor, which are known to alter both ligand binding and receptor activation. We have modified the ligand-binding region (EGF domains 11–13) of...
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Full title
Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1319683111
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1319683111
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1319683111
