Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activ...
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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cAMP is an evolutionary conserved, prototypic second messenger regulating numerous cellular functions. In mammals, cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and one soluble AC (sAC). Among these, only sAC is directly activated by bicarbonate (HCO3−); it thereby serves as a cellular sensor for HC...
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Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
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TN_cdi_crossref_primary_10_1073_pnas_1322778111
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1322778111
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1322778111
