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ArticlesPeer ReviewedFull Text
Binding site for activator MDL-801 on SIRT6
Author / Creator:You, Weijie ; Steegborn, Clemens
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2021-05, Vol.17 (5), p.519-521
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Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
Author / Creator:You, Weijie ; Zheng, Wei ; Weiss, Sandra ; Chua, Katrin F. ; Steegborn, Clemens
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-12, Vol.9 (1), p.19176-11, Article 19176
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Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism
Author / Creator:Gertz, Melanie ; Fischer, Frank ; Nguyen, Giang Thi Tuyet ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Weyand, Michael ; Steegborn, Clemens
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (30), p.E2772-E2781
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Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
Author / Creator:Pannek, Martin ; Simic, Zeljko ; Fuszard, Matthew ; Meleshin, Marat ; Rotili, Dante ; Mai, Antonello ; Schutkowski, Mike ; Steegborn, Clemens
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1513-13, Article 1513
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Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
Author / Creator:Schweizer, Ulrich ; Schlicker, Christine ; Braun, Doreen ; Köhrle, Josef ; Steegborn, Clemens
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10526-10531
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On-demand male contraception via acute inhibition of soluble adenylyl cyclase
Author / Creator:Balbach, Melanie ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Ritagliati, Carla ; Myers, Robert W. ; Huggins, David J. ; Steegborn, Clemens ; Miranda, Ileana C. ; Meinke, Peter T. ; Buck, Jochen ; Levin, Lonny R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-02, Vol.14 (1), p.637-637, Article 637
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A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
Author / Creator:Gertz, Melanie ; Nguyen, Giang Thi Tuyet ; Fischer, Frank ; Suenkel, Benjamin ; Schlicker, Christine ; Fränzel, Benjamin ; Tomaschewski, Jana ; Aladini, Firouzeh ; Becker, Christian ; Wolters, Dirk ; Steegborn, Clemens
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-11, Vol.7 (11), p.e49761-e49761
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
Author / Creator:Rumpf, Tobias ; Schiedel, Matthias ; Karaman, Berin ; Roessler, Claudia ; North, Brian J. ; Lehotzky, Attila ; Oláh, Judit ; Ladwein, Kathrin I. ; Schmidtkunz, Karin ; Gajer, Markus ; Pannek, Martin ; Steegborn, Clemens ; Sinclair, David A. ; Gerhardt, Stefan ; Ovádi, Judit ; Schutkowski, Mike ; Sippl, Wolfgang ; Einsle, Oliver ; Jung, Manfred
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-02, Vol.6 (1), p.6263-6263, Article 6263
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The Lifespan-Regulator p66Shc in Mitochondria: Redox Enzyme or Redox Sensor?
Author / Creator:Gertz, Melanie ; Steegborn, Clemens
Publisher:United States: Mary Ann Liebert, Inc
Journal title:Antioxidants & redox signaling, 2010-11, Vol.13 (9), p.1417-1428
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Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Author / Creator:Kleinboelting, Silke ; Diaz, Ana ; Moniot, Sebastien ; van den Heuvel, Joop ; Weyand, Michael ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3727-3732
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ArticlesPeer ReviewedFull Text
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Author / Creator:de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago Fleming
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-03, Vol.15 (3), p.e2000374
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ArticlesPeer ReviewedFull Text
Structural and functional features of a collagen-binding matrix protein from the mussel byssus
Author / Creator:Suhre, Michael H. ; Gertz, Melanie ; Steegborn, Clemens ; Scheibel, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-02, Vol.5 (1), p.3392-3392, Article 3392
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ArticlesPeer ReviewedFull Text
Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition
Author / Creator:Fischer, Frank ; Gertz, Melanie ; Suenkel, Benjamin ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Steegborn, Clemens
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-09, Vol.7 (9), p.e45098
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The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia
Author / Creator:Chen, Xiqun ; Wales, Pauline ; Quinti, Luisa ; Zuo, Fuxing ; Moniot, Sébastien ; Herisson, Fanny ; Rauf, Nazifa Abdul ; Wang, Hua ; Silverman, Richard B. ; Ayata, Cenk ; Maxwell, Michelle M. ; Steegborn, Clemens ; Schwarzschild, Michael A. ; Outeiro, Tiago F. ; Kazantsev, Aleksey G.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-01, Vol.10 (1), p.e0116919
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ArticlesPeer ReviewedFull Text
Crystal structure of the guanylyl cyclase Cya2
Author / Creator:Rauch, Annika ; Leipelt, Martina ; Russwurm, Michael ; Steegborn, Clemens
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (41), p.15720-15725
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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
Author / Creator:Ramos-Espiritu, Lavoisier ; Kleinboelting, Silke ; Navarrete, Felipe A ; Alvau, Antonio ; Visconti, Pablo E ; Valsecchi, Federica ; Starkov, Anatoly ; Manfredi, Giovanni ; Buck, Hannes ; Adura, Carolina ; Zippin, Jonathan H ; van den Heuvel, Joop ; Glickman, J Fraser ; Steegborn, Clemens ; Levin, Lonny R ; Buck, Jochen
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2016-10, Vol.12 (10), p.838-844
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Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization
Author / Creator:Towell, Holly ; Braun, Doreen ; Brol, Alexander ; di Fonzo, Andrea ; Rijntjes, Eddy ; Köhrle, Josef ; Schweizer, Ulrich ; Steegborn, Clemens
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2024-11, Vol.14 (11), p.1373
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A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
Author / Creator:Schuster, Sabine ; Roessler, Claudia ; Meleshin, Marat ; Zimmermann, Philipp ; Simic, Zeljko ; Kambach, Christian ; Schiene-Fischer, Cordelia ; Steegborn, Clemens ; Hottiger, Michael O. ; Schutkowski, Mike
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-03, Vol.6 (1), p.22643-22643, Article 22643
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Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein
Author / Creator:Adolph, Ramona S. ; Beck, Eileen ; Schweimer, Kristian ; Di Fonzo, Andrea ; Weyand, Michael ; Rösch, Paul ; Wöhrl, Birgitta M. ; Steegborn, Clemens
Publisher:Switzerland: MDPI AG
Journal title:Life (Basel, Switzerland), 2023-04, Vol.13 (4), p.949
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Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
Author / Creator:Steegborn, Clemens ; Litvin, Tatiana N ; Levin, Lonny R ; Buck, Jochen ; Wu, Hao
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2005-01, Vol.12 (1), p.32-37
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Showing 1 to 20 of 49 results

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Binding site for activator MDL-801 on SIRT6

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Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives

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Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism

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Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

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Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

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On-demand male contraception via acute inhibition of soluble adenylyl cyclase

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A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

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The Lifespan-Regulator p66Shc in Mitochondria: Redox Enzyme or Redox Sensor?

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Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

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The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

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Structural and functional features of a collagen-binding matrix protein from the mussel byssus

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Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

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The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

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Crystal structure of the guanylyl cyclase Cya2

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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

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Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization

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A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions

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Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

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Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment

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