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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1421182112

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

About this item

Full title

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Author / Creator

Ohnishi, Takayuki , Yanazawa, Masako , Sasahara, Tomoya , Kitamura, Yasuki , Hiroaki, Hidekazu , Fukazawa, Yugo , Kii, Isao , Nishiyama, Takashi , Kakita, Akiyoshi , Takeda, Hiroyuki , Takeuchi, Akihide , Arai, Yoshie , Ito, Akane , Komura, Hitomi , Hirao, Hajime , Satomura, Kaori , Inoue, Masafumi , Muramatsu, Shin-ichi , Matsui, Ko , Tada, Mari , Sato, Michio , Saijo, Eri , Shigemitsu, Yoshiki , Sakai, Satoko , Umetsu, Yoshitaka , Goda, Natsuko , Takino, Naomi , Takahashi, Hitoshi , Hagiwara, Masatoshi , Sawasaki, Tatsuya , Iwasaki, Genji , Nakamura, Yu , Nabeshima, Yo-ichi , Teplow, David B. and Hoshi, Minako

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4465-E4474

Language

English

Formats

Articles

Publication information

Publisher

United States: National Academy of Sciences

Subjects

More information

Scope and Contents

Contents

Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here,...

Alternative Titles

Full title

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1421182112

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1421182112

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1421182112

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