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Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1506749112

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

About this item

Full title

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (34), p.E4707-E4716

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Ribosome biogenesis requires multiple assembly factors. InEscherichia coli, deletion of RlmE, the methyltransferase responsible for the 2′-O-methyluridine modification at position 2552 (Um2552) in helix 92 of the 23S rRNA, results in slow growth and accumulation of the 45S particle. We demonstrate that the 45S particle that accumulates in ΔrlmEis a...

Alternative Titles

Full title

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1506749112

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1506749112

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1506749112

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