Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells an...
Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b⁺ dendritic cells
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4⁺ T cells specific for an MHC class II-bound peptide from the mucosal pathogenStreptococcus pyogenes. S. pyogenesMHC class II-bound peptide-specific CD4⁺ T cells were first activated in the cervical lymph nod...
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Full title
Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b⁺ dendritic cells
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TN_cdi_crossref_primary_10_1073_pnas_1513532112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1513532112
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1513532112
