Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding, aggregation, and cytotoxicity in Huntington’s disease. This incurable neurodegenerative disease is the most prevalent member of a family of CAG repeat expansion disorders. Although mature exon1 fibrils are viable candidates for the toxic species, their molecular str...
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Full title
Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1521933113
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1521933113
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1521933113
