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Mutations in the Drosophila tricellular junction protein M6 synergize with Ras V12 to induce apical...

Mutations in the Drosophila tricellular junction protein M6 synergize with Ras V12 to induce apical...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1807343115

Mutations in the Drosophila tricellular junction protein M6 synergize with Ras V12 to induce apical cell delamination and invasion

About this item

Full title

Mutations in the Drosophila tricellular junction protein M6 synergize with Ras V12 to induce apical cell delamination and invasion

Publisher

United States

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (33), p.8358-8363

Language

English

Formats

Publication information

Publisher

United States

More information

Scope and Contents

Contents

Complications from metastasis are responsible for the majority of cancer-related deaths. Despite the outsized medical impact of metastasis, remarkably little is known about one of the key early steps of metastasis: departure of a tumor cell from its originating tissue. It is well documented that cellular delamination in the basal direction can indu...

Alternative Titles

Full title

Mutations in the Drosophila tricellular junction protein M6 synergize with Ras V12 to induce apical cell delamination and invasion

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1807343115

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1807343115

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1807343115

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