What ATP binding does to the Ca 2+ pump and how nonproductive phosphoryl transfer is prevented in th...
What ATP binding does to the Ca 2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca 2
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Publisher
United States
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Language
English
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United States
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Under physiological conditions, most Ca
-ATPase (SERCA) molecules bind ATP before binding the Ca
transported. SERCA has a high affinity for ATP even in the absence of Ca
, and ATP accelerates Ca
binding at pH values lower than 7, where SERCA is in the E2 state with low-affinity Ca
-binding sites. Here we describe the crystal structur...
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Full title
What ATP binding does to the Ca 2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca 2
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TN_cdi_crossref_primary_10_1073_pnas_2006027117
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_2006027117
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2006027117
