Molecular Cloning and Functional Expression of a Human cDNA Encoding the Antimutator Enzyme 8-hydrox...
Molecular Cloning and Functional Expression of a Human cDNA Encoding the Antimutator Enzyme 8-hydroxyguanine-DNA Glycosylase
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United States: National Academy of Sciences of the United States of America
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Language
English
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United States: National Academy of Sciences of the United States of America
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Contents
The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxy-guanine (8-oxo-7,8-dihydroguanine). In bacteria and Saccharomyces cerevisiae, this damaged base is excised by a DNA glycosylase with an associated lyase activity for chain cleavage. We have cloned, sequenced, and expressed a human cDNA with partial seq...
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Full title
Molecular Cloning and Functional Expression of a Human cDNA Encoding the Antimutator Enzyme 8-hydroxyguanine-DNA Glycosylase
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TN_cdi_crossref_primary_10_1073_pnas_94_15_8016
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_94_15_8016
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.94.15.8016
