The inhibition mechanism of human 20 S proteasomes enables next-generation inhibitor design
The inhibition mechanism of human 20 S proteasomes enables next-generation inhibitor design
About this item
Full title
The inhibition mechanism of human 20 S proteasomes enables next-generation inhibitor design
Author / Creator
Journal title
Science (American Association for the Advancement of Science), 2016-08, Vol.353 (6299), p.594-598
Language
English
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Scope and Contents
Contents
Proteasomes are large protein complexes that degrade and remove proteins to maintain proper cellular physiology and growth. Proteasomes are a validated target for anticancer therapy, but drug design has been hampered by poor understanding of how inhibitors interact with the active site. Schrader
et al.
succeeded in crystallizing various prote...
Alternative Titles
Full title
The inhibition mechanism of human 20 S proteasomes enables next-generation inhibitor design
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1126_science_aaf8993
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_aaf8993
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf8993
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