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Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_aal0092

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

About this item

Full title

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Publisher

United States

Journal title

Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6326), p.756-760

Language

English

Formats

Publication information

Publisher

United States

More information

Scope and Contents

Contents

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneratio...

Alternative Titles

Full title

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1126_science_aal0092

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_aal0092

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aal0092

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