DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents a...
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response
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Full title
Author / Creator
Yulyaningsih, Ernie , Suh, Jung H , Fanok, Melania , Chau, Roni , Solanoy, Hilda , Takahashi, Ryan , Bakardjiev, Anna I , Becerra, Isabel , Benitez, N Butch , Chiu, Chi-Lu , Davis, Sonnet S , Dowdle, William E , Earr, Timothy , Estrada, Anthony A , Gill, Audrey , Ha, Connie , Haddick, Patrick CG , Henne, Kirk R , Larhammar, Martin , Leung, Amy W-S , Maciuca, Romeo , Memarzadeh, Bahram , Nguyen, Hoang N , Nugent, Alicia A , Osipov, Maksim , Ran, Yingqing , Rebadulla, Kevin , Roche, Elysia , Sandmann, Thomas , Wang, Jing , Lewcock, Joseph W , Scearce-Levie, Kimberly , Kane, Lesley A and Sanchez, Pascal E
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR activation perturbs cell function and may contribute to neurodegeneration. DNL343 is an investigationa...
Alternative Titles
Full title
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response
Authors, Artists and Contributors
Author / Creator
Suh, Jung H
Fanok, Melania
Chau, Roni
Solanoy, Hilda
Takahashi, Ryan
Bakardjiev, Anna I
Becerra, Isabel
Benitez, N Butch
Chiu, Chi-Lu
Davis, Sonnet S
Dowdle, William E
Earr, Timothy
Estrada, Anthony A
Gill, Audrey
Ha, Connie
Haddick, Patrick CG
Henne, Kirk R
Larhammar, Martin
Leung, Amy W-S
Maciuca, Romeo
Memarzadeh, Bahram
Nguyen, Hoang N
Nugent, Alicia A
Osipov, Maksim
Ran, Yingqing
Rebadulla, Kevin
Roche, Elysia
Sandmann, Thomas
Wang, Jing
Lewcock, Joseph W
Scearce-Levie, Kimberly
Kane, Lesley A
Sanchez, Pascal E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_7554_eLife_92173_3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_92173_3
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.92173.3
