Nucleotide excision repair is impaired by binding of transcription factors to DNA
Nucleotide excision repair is impaired by binding of transcription factors to DNA
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
An analysis of cancer genomic data reveals an increased rate of somatic mutations at active transcription factor binding sites located both within promoter regions and distal from genes; the increased mutation rate at these genomic regions can be explained by reduced accessibility of the protein-bound DNA to nucleotide excision repair machinery.
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Full title
Nucleotide excision repair is impaired by binding of transcription factors to DNA
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Record Identifier
TN_cdi_csuc_recercat_oai_recercat_cat_2072_314936
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_csuc_recercat_oai_recercat_cat_2072_314936
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17661
