The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
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Author / Creator
Li, Feng , Lo, Tsz Y. , Miles, Leann , Wang, Qin , Noristani, Harun N. , Li, Dan , Niu, Jingwen , Trombley, Shannon , Goldshteyn, Jessica I. , Wang, Chuxi , Wang, Shuchao , Qiu, Jingyun , Pogoda, Katarzyna , Mandal, Kalpana , Brewster, Megan , Rompolas, Panteleimon , He, Ye , Janmey, Paul A. , Thomas, Gareth M. , Li, Shuxin and Song, Yuanquan
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. We show that in
Drosophila
sensory neurons removing Atr or Chek1, or overexpressing Cdc25 promo...
Alternative Titles
Full title
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
Authors, Artists and Contributors
Author / Creator
Lo, Tsz Y.
Miles, Leann
Wang, Qin
Noristani, Harun N.
Li, Dan
Niu, Jingwen
Trombley, Shannon
Goldshteyn, Jessica I.
Wang, Chuxi
Wang, Shuchao
Qiu, Jingyun
Pogoda, Katarzyna
Mandal, Kalpana
Brewster, Megan
Rompolas, Panteleimon
He, Ye
Janmey, Paul A.
Thomas, Gareth M.
Li, Shuxin
Song, Yuanquan
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_005c24fb0ae4423db9855a4fda43b7ac
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_005c24fb0ae4423db9855a4fda43b7ac
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24131-7
